INT87236

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Context Info
Confidence 0.24
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.75
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
macrophages 3
T cells 1
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.78 Very High Very High Very High
cocaine 3 99.12 Very High Very High Very High
cytokine 45 97.00 Very High Very High Very High
drug abuse 1 89.12 High High
Inflammation 15 52.24 Quite High
Arthritis 6 38.56 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
tail-flick 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 89.12 High High
Immunization 5 80.84 Quite High
Candida Infection 8 80.32 Quite High
Infection 3 74.24 Quite High
INFLAMMATION 15 52.24 Quite High
Autoimmune Disease 3 40.64 Quite Low
Arthritis 3 38.56 Quite Low
Graft Vs Host Disease 15 12.32 Low Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Regulation (resulted) of Negative_regulation (decrease) of IL-2 mRNA associated with morphine
1) Confidence 0.24 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.67
In this model, the exposure to morphine (25 mg/kg, 5 days before, during and 5 days after inoculation with the yeast) significant decreased IL-2 and IL-4 levels, while secretion of IFN-gamma was unaltered.
Regulation (unaltered) of Negative_regulation (decreased) of IL-2 associated with morphine
2) Confidence 0.18 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.31 Pain Relevance 0.59
is released from T cells and macrophages, which proliferate the process of phagocytosis.[2122] However, the significant reduction in IL-2 and IFN-?
Regulation (proliferate) of Negative_regulation (reduction) of IL-2 in macrophages
3) Confidence 0.11 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.11 Pain Relevance 0.13
The inhibition of IL-2 is possibly responsible for the reduced secretion of IFN- ?
Spec (possibly) Regulation (responsible) of Negative_regulation (inhibition) of IL-2
4) Confidence 0.11 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.13 Pain Relevance 0.10
is released from T cells and macrophages, which proliferate the process of phagocytosis.[2122] However, the significant reduction in IL-2 and IFN-?
Regulation (proliferate) of in T cells Negative_regulation (reduction) of IL-2 in macrophages
5) Confidence 0.04 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.11 Pain Relevance 0.13

General Comments

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