INT87239

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 31.95
Pain Relevance 12.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 4
T cells 4
dendritic cells 3
microglia 3
spleen 2
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 795 100.00 Very High Very High Very High
Inflammation 706 100.00 Very High Very High Very High
Inflammatory mediators 26 100.00 Very High Very High Very High
agonist 196 99.92 Very High Very High Very High
Multiple sclerosis 342 99.80 Very High Very High Very High
chemokine 111 99.76 Very High Very High Very High
withdrawal 26 99.56 Very High Very High Very High
Clonidine 2 98.92 Very High Very High Very High
anesthesia 14 98.86 Very High Very High Very High
endometriosis 64 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 798 100.00 Very High Very High Very High
Disease 722 100.00 Very High Very High Very High
Vibrio Infection 2 100.00 Very High Very High Very High
Infection 479 99.80 Very High Very High Very High
Multiple Sclerosis 350 99.80 Very High Very High Very High
Cancer 925 99.48 Very High Very High Very High
Immunization 218 99.42 Very High Very High Very High
Endometriosis 74 98.72 Very High Very High Very High
Splenomegaly 5 98.60 Very High Very High Very High
Severe Combined Immunodeficiency 1 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms of antitumor action of interleukin 12 include the enforced secretion of anti-angiogenic factors and stimulation of antitumor immunity.
Localization (secretion) of interleukin 12
1) Confidence 0.75 Published 2000 Journal Life Sci. Section Abstract Doc Link 10737417 Disease Relevance 0.51 Pain Relevance 0.18
These findings show that alpha(2)-adrenoceptor agonists induce interleukin-12 production in mouse macrophages via a PKC/p38 MAPK signaling pathway and suggest that the effect of alpha(2)-adrenoceptor agonists on interleukin-12 secretion may be a new and novel means of augmenting cell-mediated immune responses.
Localization (secretion) of interleukin-12 in macrophages associated with kinase c and agonist
2) Confidence 0.73 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.52
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Localization (secretion) of interleukin-12 in macrophages associated with agonist and clonidine
3) Confidence 0.64 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.44
ameliorated disease in recipients of either IL-12– or IL-23–modulated, PLP-reactive cells.
Localization (disease) of IL-12 associated with disease
4) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.92 Pain Relevance 0.18
A major finding from these studies was that IL-12 was decreased following withdrawal, and it was concluded that this decrease may be a mechanism by which morphine withdrawal is mediating Th2 polarization.
Localization (decreased) of IL-12 associated with withdrawal and morphine
5) Confidence 0.35 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.88
There is some evidence that IL-12 has anti-tumor activity as the systemic administration of IL-12 in mice leads to anti-tumor activity7,65 and IL-23 may promote tumor formation.5 Lastly, while ustekinumab did not help in inhibiting RRMS, it is noteworthy that it did not create any neurological events as other biological agents, such as anti-TNF-?
Localization (administration) of IL-12 associated with multiple sclerosis and cancer
6) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.35 Pain Relevance 0.26
Symptoms gradually recurred in patients who therapy was withdrawn and quality of life improvements were lost, indicting the block of IL-12 and IL-23 is temporary and does not reverse the underlying causal mechanism of psoriasis.
Neg (block) Localization (block) of IL-12 associated with psoriasis
7) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.71 Pain Relevance 0.19
and IL-12 secretion, a characteristic also seen in endometriosis patients (Rana et al., 1996; Wu et al., 1999).
Localization (secretion) of IL-12 associated with endometriosis
8) Confidence 0.31 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2569845 Disease Relevance 0.76 Pain Relevance 0.31
At 21 days after treatment, all mice were killed under ether anesthesia, and blood, spleen and tumor samples were obtained, for quantification of serum IL-2, IL-12 and IFN-?
Localization (quantification) of IL-12 in blood associated with anesthesia and cancer
9) Confidence 0.28 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892347 Disease Relevance 1.25 Pain Relevance 0.14
It is interesting to note that BALB/c mice are known to have a low response to LPS and IL-12.
Localization (response) of IL-12
10) Confidence 0.28 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892347 Disease Relevance 1.02 Pain Relevance 0
At 21 days after treatment, all mice were killed under ether anesthesia, and blood, spleen and tumor samples were obtained, for quantification of serum IL-2, IL-12 and IFN-?
Localization (serum) of IL-12 in spleen associated with anesthesia and cancer
11) Confidence 0.28 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892347 Disease Relevance 1.24 Pain Relevance 0.14
or CD40) stimulates secretion of the bioactive, heterodimeric form of IL-12 (i.e., IL-12p70) and ATP?
Localization (form) of IL-12
12) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.23
Activated microglia and astrocytes after KA treatment release a large amount of inflammatory mediators such as NO, IL-6, IL-12, TGF-?
Localization (release) of IL-12 in astrocytes associated with inflammatory mediators
13) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 1.38 Pain Relevance 0.40
LPS and CD40L-induced secretion of IL-12 from macrophage, microglia, and
Localization (secretion) of IL-12 in microglia
14) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.70 Pain Relevance 0.40
that autoimmune cells secrete IL-12 in response to antigens and that this
Localization (secrete) of IL-12
15) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.82 Pain Relevance 0.42
We have not yet identified the cellular source of the cytokines seen in BAL, but rAd can infect immature dendritic cells (DC) from both mice and humans, causing them to mature and secrete IL-12 [58], [59].
Localization (secrete) of IL-12 in dendritic cells associated with cytokine
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953831 Disease Relevance 0.41 Pain Relevance 0.08
levels in BAL after i.n. rAd immunization could result from continued IL-12 secretion.
Localization (secretion) of IL-12 associated with immunization
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953831 Disease Relevance 0.36 Pain Relevance 0.08
As shown in Figure 3, splenocytes from Balb/c mice treated with CpG ODN fma1555 had a delayed increase in IL-6 and IL-12 secreting cells when compared to mice that received CpG ODN 1555.
Localization (secreting) of IL-12
18) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0 Pain Relevance 0.14
Importantly, the number of IL-12 secreting cells was still increased 120 h after treatment, as compared to mice receiving CpG ODN 1555.
Localization (secreting) of IL-12
19) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0 Pain Relevance 0.15
After incubation, supernatants were harvested and assayed for secreted IL-12 and IL-10 by commercial ELISA kits (Biosource International, CA, USA).
Localization (secreted) of IL-12
20) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.32 Pain Relevance 0

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