INT8724

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Context Info
Confidence 0.66
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 14.12
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
T cells 2
esophageal sphincter 1
lymphocyte 1
superior 1
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 12 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Enkephalin 4 99.96 Very High Very High Very High
Duloxetine 11 99.90 Very High Very High Very High
pregabalin 11 99.80 Very High Very High Very High
Catecholamine 2 99.40 Very High Very High Very High
spastic colon 16 99.12 Very High Very High Very High
Pain 3 98.68 Very High Very High Very High
Chronic pancreatitis 4 98.36 Very High Very High Very High
Calcitonin gene-related peptide 1 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diarrhoea 8 99.62 Very High Very High Very High
Food Poisoning 3 99.60 Very High Very High Very High
Pancreatitis 5 99.24 Very High Very High Very High
Porphyria 4 99.14 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 99.12 Very High Very High Very High
Natriuresis 1 99.02 Very High Very High Very High
Vibrio Infection 1 98.72 Very High Very High Very High
Pain 3 98.68 Very High Very High Very High
Apoptosis 128 98.52 Very High Very High Very High
Stress 7 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased motilin levels might then participate in a vicious diarrhea circle together with the other agents.
Positive_regulation (increased) of motilin associated with diarrhoea
1) Confidence 0.66 Published 1987 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2447632 Disease Relevance 0.73 Pain Relevance 0.08
Motilin's induction of phasic contractility in canine jejunum is mediated by the luminal release of serotonin.
Positive_regulation (induction) of Motilin in jejunum associated with serotonin
2) Confidence 0.50 Published 1986 Journal Surgery Section Title Doc Link 3738764 Disease Relevance 0 Pain Relevance 0.15
The contractile response to EM-523 or motilin was reduced markedly after treatment of the preparation with a high concentration of either agent, and cross-tachyphylaxis between EM-523 and motilin was also observed.
Positive_regulation (response) of motilin
3) Confidence 0.49 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2395122 Disease Relevance 0 Pain Relevance 0.13
Thirty-eight (52%) of the 73 patients had elevated (greater than 126 pmol/l) plasma concentrations of motilin, whereas 59 (81%) of the patients had diarrhea.
Positive_regulation (elevated) of motilin in plasma associated with diarrhoea
4) Confidence 0.45 Published 1987 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2447632 Disease Relevance 1.14 Pain Relevance 0.16
These results suggest that muscarinic receptors are present on the motilin cell membrane and that acetylcholine is a major regulator of motilin release.
Positive_regulation (regulator) of motilin
5) Confidence 0.42 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.22
This supported earlier data showing that lymphocyte accumulation in MLN was part of an active rather than passive process.
Positive_regulation (accumulation) of MLN in lymphocyte
6) Confidence 0.39 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 0.98 Pain Relevance 0
Motilin also increased significantly in the IBS patients after the stress (p less than 0.01).
Positive_regulation (increased) of Motilin associated with stress and spastic colon
7) Confidence 0.39 Published 1987 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 3617051 Disease Relevance 0.58 Pain Relevance 0.64
In fasting studies, there was a trend (P = 0.23) toward increased fasting serum motilin in paraplegic patients, and this result did not support tonic inhibition of motilin release.
Positive_regulation (increased) of motilin
8) Confidence 0.38 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.58 Pain Relevance 0.20
In healthy volunteers, there are postprandial increases in plasma peptide YY and motilin levels, which appear related to neural mechanisms.
Positive_regulation (increases) of motilin in neural
9) Confidence 0.38 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.69 Pain Relevance 0.21
The significance of the lower esophageal sphincter pressure increase with moderate exercise is unknown but may relate to the observed exercise-induced increase in serum motilin, gastrin, and catecholamines.
Positive_regulation (increase) of motilin in esophageal sphincter associated with catecholamine
10) Confidence 0.38 Published 1986 Journal Am. J. Gastroenterol. Section Abstract Doc Link 3776951 Disease Relevance 0.33 Pain Relevance 0.12
CD4+ T cells are known to maximally populate MLN, as these are the cells mainly responsible for the immune response that is prevalent at these sites in TI and sepsis.
Positive_regulation (populate) of MLN in T cells associated with injury and sepsis
11) Confidence 0.28 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.97 Pain Relevance 0
Both effects increased with increasing motilin concentrations.
Positive_regulation (increasing) of motilin
12) Confidence 0.27 Published 1991 Journal Peptides Section Abstract Doc Link 1800946 Disease Relevance 0 Pain Relevance 0.12
DLX was superior to MLN and PGB in reducing depressed mood.
Positive_regulation (superior) of MLN in superior associated with pregabalin and duloxetine
13) Confidence 0.24 Published 2010 Journal J Pain Section Abstract Doc Link 20418173 Disease Relevance 1.11 Pain Relevance 1.82
In diarrhoea fasting levels of motilin and PP and postprandial level of PP were increased.
Positive_regulation (increased) of motilin associated with diarrhoea
14) Confidence 0.21 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.34 Pain Relevance 0.73
The plasma concentrations of arginine vasopressin, atrial natriuretic peptide, beta-endorphin, methionine-enkephalin, motilin, neuropeptide Y, substance P, and vasoactive intestinal peptide were increased.
Positive_regulation (increased) of motilin in plasma associated with natriuresis, neuropeptide, enkephalin and substance p
15) Confidence 0.18 Published 1992 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 1378231 Disease Relevance 0.26 Pain Relevance 0.29
This refers especially to VIP, motilin, and enteroglucagon, the plasma concentrations of which are elevated in acute infectious diarrhoea, cholera, and tropical malabsorption.
Positive_regulation (elevated) of motilin in plasma associated with food poisoning and vibrio infection
16) Confidence 0.13 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6356326 Disease Relevance 0.37 Pain Relevance 0.12
The prokinetic effects of ghrelin on GI motility involve the exclusive activation of the GHS-R 1a receptor, not the motilin receptor, the enteric nervous system (specifically the myenteric plexus), excitatory neurons involving 5-HT4 and NO, capsaicin-sensitive afferent neurons, tachykininergic motor neurons, as well as intact vagal cholinergic neurons.
Positive_regulation (activation) of motilin in motor neurons associated with qutenza
17) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915793 Disease Relevance 0.64 Pain Relevance 0.43
Basal motilin levels were elevated in both groups of pancreatitis (p less than 0.05).
Positive_regulation (elevated) of motilin associated with pancreatitis
18) Confidence 0.05 Published 1984 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6367435 Disease Relevance 1.52 Pain Relevance 0.31
There was significant blunting of insulin and gastric inhibitory polypeptide secretion, with complete abolition of the normal postprandial increases in pancreatic polypeptide and motilin.
Positive_regulation (increases) of motilin
19) Confidence 0.03 Published 1983 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6846306 Disease Relevance 0 Pain Relevance 0.25
During acute attacks of porphyria, polypeptides were found to be constantly increased: vasoactive intestinal polypeptide (VIP); neurotensin (NT); substance P; pancreatic polypeptide; gastrin-releasing peptide; gastrin and motilin.
Positive_regulation (increased) of motilin associated with porphyria and substance p
20) Confidence 0.02 Published 1997 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 9074785 Disease Relevance 0.76 Pain Relevance 0.20

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