INT87240

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Context Info
Confidence 0.11
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.41
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Aggf1) extracellular region (Aggf1) cell adhesion (Aggf1)
intracellular (Aggf1) cytoplasm (Aggf1)
Anatomy Link Frequency
fibroblasts 1
bladders 1
PSP 1
neutrophils 1
Aggf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 97.04 Very High Very High Very High
cytokine 21 95.28 Very High Very High Very High
chemokine 5 94.40 High High
ketamine 3 93.92 High High
cINOD 4 93.56 High High
agonist 8 87.84 High High
addiction 2 75.00 Quite High
anesthesia 12 72.88 Quite High
fibrosis 46 71.80 Quite High
Inflammatory response 13 44.80 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 51 99.84 Very High Very High Very High
Cancer 260 99.44 Very High Very High Very High
Corneal Neovascularization 49 98.46 Very High Very High Very High
INFLAMMATION 104 97.04 Very High Very High Very High
Colon Cancer 11 96.64 Very High Very High Very High
Hypoxia 6 95.00 High High
Bladder Cancer 206 94.84 High High
Pseudomonas Infection 36 93.44 High High
Toxicity 26 90.20 High High
Metastasis 8 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-CL initiated by MPEG using stannous octoate as catalyst, and biodegradable PECE triblock copolymer was synthesized from PEG-PCL diblock copolymer using HMDI as coupling agent.
Gene_expression (synthesized) of PEG
1) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2920883 Disease Relevance 0.56 Pain Relevance 0
A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized.
Gene_expression (synthesized) of PEG-PCL-PEG
2) Confidence 0.10 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2920883 Disease Relevance 0.82 Pain Relevance 0
Intramuscular injections of PEG-PEI-ESO polyplexes
Gene_expression (injections) of PEG
3) Confidence 0.07 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0.12
It has recently been demonstrated that these drugs are capable of suppressing the production of pro-angiogenic factors from tumor cells.
Gene_expression (production) of pro-angiogenic associated with cancer
4) Confidence 0.05 Published 2000 Journal Life Sci. Section Abstract Doc Link 10737417 Disease Relevance 0.49 Pain Relevance 0.17
PLGA-PEG synthesis
Gene_expression (synthesis) of PEG
5) Confidence 0.04 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.53 Pain Relevance 0.15
Release kinetics of nile red from PLGA-PEG nanoparticles was quantified by recording absorption of released dye in resuspension buffer (PBS, 100 ?
Gene_expression (nanoparticles) of PEG
6) Confidence 0.04 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0 Pain Relevance 0
Two PegIFNs [11, 12] were studied: (a) PegIFN-?
Gene_expression ([11) of PegIFNs
7) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 0.25 Pain Relevance 0
Two PegIFNs [11, 12] were studied: (a) PegIFN-?
Gene_expression (studied) of PegIFNs
8) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 0.25 Pain Relevance 0
Our earlier results have shown increased expression of angiogenic growth factor VEGF at 72 h post PDT [39].
Gene_expression (expression) of angiogenic growth factor VEGF
9) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.65 Pain Relevance 0
Additionally, the anti-angiogenic factor, TSP1, which plays a strong angiogenic-inhibitory role and whose expression is suppressed by androgens, was investigated.
Gene_expression (expression) of anti-angiogenic factor
10) Confidence 0.03 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.71 Pain Relevance 0.04
TSP1, an anti-angiogenic factor whose expression is inhibited by androgens, had decreased expression in bladders of UPII-SV40T mice compared to wild-type.
Gene_expression (expression) of anti-angiogenic factor in bladders
11) Confidence 0.03 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 1.21 Pain Relevance 0.04
In that context, macrophages, myelomonocytes, and neutrophils are the most commonly seen cellular populations, all of which are main sources of pro-angiogenic or anti-angiogenic factors [3-5].
Gene_expression (sources) of pro-angiogenic in neutrophils
12) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.82 Pain Relevance 0.21
As shown in Figure 5, PSP suppressed the expression of VEGF, MMP2, and MMP9 and stimulated the expression of PEDF, suggesting that PSP may inhibit CNV by downregulating the expression of angiogenic factors and upregulating the expression of the anti-angiogenic factor.
Gene_expression (expression) of anti-angiogenic factor in PSP associated with corneal neovascularization
13) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 1.04 Pain Relevance 0.19
Therefore, in the present study we addressed the question whether glucose concentration might somehow modulate proliferation, migration and angiogenic gene expression in diabetic dermal fibroblasts exposed to sole or combined rhVEGF-A and rhFGF4 treatment.
Gene_expression (expression) of angiogenic gene in fibroblasts associated with diabetes mellitus
14) Confidence 0.02 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 1.08 Pain Relevance 0

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