INT8725

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Context Info
Confidence 0.77
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 14.90
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 8
bowel 3
Purkinje cells 2
duodenum 1
endocrine cells 1
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
Cholecystokinin 11 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Neuropeptide 26 99.80 Very High Very High Very High
Enkephalin 8 99.76 Very High Very High Very High
spastic colon 75 99.56 Very High Very High Very High
narcan 4 99.20 Very High Very High Very High
intrathecal 5 99.18 Very High Very High Very High
Serotonin 4 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Carcinoid 17 99.84 Very High Very High Very High
Diarrhoea 10 99.82 Very High Very High Very High
Apoptosis 61 99.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

57 99.56 Very High Very High Very High
Syndrome 7 99.54 Very High Very High Very High
Functional Bowel Disorder 23 99.12 Very High Very High Very High
Pain 8 98.76 Very High Very High Very High
Pancreatitis 3 98.44 Very High Very High Very High
Abdominal Pain 18 98.40 Very High Very High Very High
Infection 39 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that motilin receptors are strongly expressed in Purkinje cells of the human and rat cerebellum.
Gene_expression (expressed) of motilin in Purkinje cells
1) Confidence 0.77 Published 2007 Journal Neuroreport Section Abstract Doc Link 17762710 Disease Relevance 0 Pain Relevance 0.20
Evidence exists that motilin immunoreactivity is highly expressed in Purkinje cells.
Gene_expression (expressed) of motilin in Purkinje cells
2) Confidence 0.77 Published 2007 Journal Neuroreport Section Abstract Doc Link 17762710 Disease Relevance 0 Pain Relevance 0.14
The response to motilin (10(-6) M) was not only smaller than that to acetylcholine (10(-5) M), it also faded more rapidly with time.
Gene_expression (response) of motilin
3) Confidence 0.66 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2725711 Disease Relevance 0 Pain Relevance 0.11
High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome.
Gene_expression (levels) of motilin in bowel associated with spastic colon
4) Confidence 0.64 Published 2005 Journal Neurogastroenterol. Motil. Section Title Doc Link 15670264 Disease Relevance 0.36 Pain Relevance 0.84
In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex.
Gene_expression (produced) of motilin associated with narcan, overactive bladder, intracerebroventricular and intrathecal
5) Confidence 0.62 Published 1984 Journal Life Sci. Section Abstract Doc Link 6547500 Disease Relevance 0.10 Pain Relevance 0.32
The aim of this study was to compare serum motilin levels in children with and without recurrent abdominal pain, based on the assumption that recurrent abdominal pain in children is a gut motility disorder.
Gene_expression (levels) of motilin in gut associated with abdominal pain
6) Confidence 0.60 Published 1994 Journal Acta Paediatr. Section Abstract Doc Link 8086735 Disease Relevance 0.48 Pain Relevance 0.48
It is suggested, however, that future research should compare serum motilin levels during and between attacks of pain.
Gene_expression (levels) of motilin associated with pain
7) Confidence 0.60 Published 1994 Journal Acta Paediatr. Section Abstract Doc Link 8086735 Disease Relevance 0.66 Pain Relevance 0.66
Enterochromaffin cells are the major source of intestinal serotonin (5-HT), but separate subpopulations of EC cells may synthesize and store peptides as substance P (SP), motilin, and enkephalin as well.
Gene_expression (synthesize) of motilin in Enterochromaffin cells associated with enkephalin, serotonin and substance p
8) Confidence 0.59 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2412066 Disease Relevance 0.34 Pain Relevance 0.36
However, extracts from five carcinoid tumors did not contain any significant levels of motilin.
Gene_expression (levels) of motilin associated with carcinoid
9) Confidence 0.58 Published 1987 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2447632 Disease Relevance 1.02 Pain Relevance 0.14
Higher motilin levels were observed in IBS vs HC in both the interdigestive and postprandial periods (P < 0.05).
Gene_expression (levels) of motilin associated with spastic colon
10) Confidence 0.57 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15670264 Disease Relevance 0.32 Pain Relevance 0.98
In IBS patients circulating motilin levels covaried with total ghrelin levels (r=0.90; p<0.004), octanylated ghrelin (r=0.77; p<0.02) and desoctanylated ghrelin (r=0.69; p<0.04).
Gene_expression (levels) of motilin associated with spastic colon
11) Confidence 0.54 Published 2010 Journal Peptides Section Abstract Doc Link 20338210 Disease Relevance 0.16 Pain Relevance 0.63
DEAD-cell kit, Promega (TUNEL Assay) was used for in situ analysis of apoptotic cells in MLN sections.
Gene_expression (sections) of MLN in apoptotic cells associated with apoptosis
12) Confidence 0.38 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.51 Pain Relevance 0
Fasting plasma vasoactive intestinal peptide (VIP) and motilin levels were measured by peptide immunoassays.
Gene_expression (levels) of motilin in plasma
13) Confidence 0.37 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19566588 Disease Relevance 0.98 Pain Relevance 0.12
In constipated patients fasting levels of gastrin and motilin and postprandial levels of gastrin, motilin and PP were decreased.
Gene_expression (levels) of motilin
14) Confidence 0.34 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.33 Pain Relevance 0.71
Correlations are also noted between plasma VIP/Motilin levels and gastric slow waves.
Gene_expression (levels) of Motilin in plasma
15) Confidence 0.32 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19566588 Disease Relevance 0.96 Pain Relevance 0.12
In diarrhoea fasting levels of motilin and PP and postprandial level of PP were increased.
Gene_expression (levels) of motilin associated with diarrhoea
16) Confidence 0.27 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.35 Pain Relevance 0.73
In constipated patients fasting levels of gastrin and motilin and postprandial levels of gastrin, motilin and PP were decreased.
Gene_expression (levels) of motilin
17) Confidence 0.27 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.33 Pain Relevance 0.71
Blood samples were taken 30 min before and after each rectal distension procedure to determine plasma levels of cholecystokinin (CCK), pancreatic polypeptide (PP) and motilin.
Spec (determine) Gene_expression (levels) of motilin in plasma associated with cholecystokinin
18) Confidence 0.22 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18761628 Disease Relevance 0.27 Pain Relevance 0.43
The arterial blood pressure correlated with the plasma levels of motilin and neuropeptide Y.
Gene_expression (levels) of motilin in plasma associated with neuropeptide
19) Confidence 0.22 Published 1992 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 1378231 Disease Relevance 0.26 Pain Relevance 0.27
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.
Gene_expression (act) of motilin in duodenum
20) Confidence 0.17 Published 1999 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 10081621 Disease Relevance 0 Pain Relevance 0.33

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