INT87267

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (BMP8B) extracellular space (BMP8B) growth (BMP8B)
extracellular region (BMP8B) cytoskeleton (KRIT1) protein complex (KRIT1)
Anatomy Link Frequency
plasma 2
BMP8B (Homo sapiens)
KRIT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 28 100.00 Very High Very High Very High
Kinase C 2 99.92 Very High Very High Very High
agonist 2 97.72 Very High Very High Very High
Morphine 2 76.08 Quite High
opioid receptor 4 74.28 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaM was previously shown to bind directly to the OP3 receptor and to be released from the plasma membrane on agonist stimulation.
OP3 Binding (bind) of CaM in plasma associated with agonist and opioid
1) Confidence 0.06 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737597 Disease Relevance 0.08 Pain Relevance 1.32
To test whether OP3-mediated CaM release contributes to nuclear CaM signaling, we used a mutant OP3 receptor (K273A) with reduced affinity for CaM that fails to release CaM from the plasma membrane.
OP3 Binding (affinity) of CaM in plasma associated with opioid
2) Confidence 0.04 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737597 Disease Relevance 0.07 Pain Relevance 1.37

General Comments

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