INT87271

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 12.87
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
chondrocytes 2
SH-SY5Y 2
lateral column 2
spinal cord 2
colon 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 14 100.00 Very High Very High Very High
agonist 93 99.98 Very High Very High Very High
qutenza 2 99.84 Very High Very High Very High
Spinal cord 9 99.68 Very High Very High Very High
Dorsal horn neuron 3 98.92 Very High Very High Very High
alcohol 100 98.68 Very High Very High Very High
Opioid 18 98.60 Very High Very High Very High
Neurotransmitter 21 97.52 Very High Very High Very High
Sciatic nerve 3 97.40 Very High Very High Very High
long-term potentiation 34 97.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 20 100.00 Very High Very High Very High
Cystitis 22 99.54 Very High Very High Very High
Stress 252 99.36 Very High Very High Very High
Anxiety Disorder 40 98.96 Very High Very High Very High
Multiple Sclerosis 11 98.44 Very High Very High Very High
Neuroblastoma 4 97.88 Very High Very High Very High
Urological Neuroanatomy 96 96.52 Very High Very High Very High
Apoptosis 36 96.32 Very High Very High Very High
Nervous System Injury 3 95.80 Very High Very High Very High
Neuropathic Pain 19 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RHC associated variants, Arg151Cys, Arg160Trp and Asp294His, demonstrated agonist-mediated increases in cAMP and phosphorylation of cAMP-responsive element-binding protein (CREB).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of CREB associated with agonist
1) Confidence 0.66 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.16 Pain Relevance 0.39
Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.
Neg (independent) Positive_regulation (independent) of Phosphorylation (phosphorylation) of CREB
2) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.91 Pain Relevance 0.13
Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of CREB
3) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.84 Pain Relevance 0.13
Quantification of immunoblots optical densities (Odyssey Application Software, 2.0) confirmed that vinpocetine treatment significantly increased CREB phosphorylation in Ethanol treated animals without affecting total CREB levels (Figure 4b).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
The RHC associated variants, Arg151Cys, Arg160Trp and Asp294His, demonstrated agonist-mediated increases in cAMP and phosphorylation of cAMP-responsive element-binding protein (CREB).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of cAMP-responsive element-binding protein associated with agonist
5) Confidence 0.47 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.16 Pain Relevance 0.39
Stimulation of chondrocytes with beta-endorphin resulted in decreased phosphorylation of the transcription factor cAMP responsive element binding protein (CREB).
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of cAMP responsive element binding protein in chondrocytes
6) Confidence 0.46 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.34 Pain Relevance 0.64
Moreover, in HEK-OP3 and SH-SY5Y cells, increased nuclear CaM content was associated with enhanced phosphorylation of the nuclear transcription factor cyclic AMP-responsive element-binding protein.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of cyclic AMP-responsive element-binding protein in SH-SY5Y associated with opioid
7) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737597 Disease Relevance 0.09 Pain Relevance 1.24
Increased phosphorylation of cyclic AMP response element-binding protein (CREB) in the superficial dorsal horn neurons following partial sciatic nerve ligation.
Spec (partial) Positive_regulation (Increased) of Phosphorylation (phosphorylation) of cyclic AMP response element-binding protein in dorsal horn associated with sciatic nerve and dorsal horn neuron
8) Confidence 0.40 Published 2001 Journal Pain Section Title Doc Link 11514088 Disease Relevance 0.95 Pain Relevance 0.94
We conclude that cAMP can induce c-IAP2 expression in colon cancer cells through CREB phosphorylation and CRE-dependent transcription in a manner that involves activation of ERK1/2 and p38 MAPK.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of CREB in colon associated with colon cancer
9) Confidence 0.39 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.85 Pain Relevance 0.09
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of CREB associated with agonist
10) Confidence 0.39 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.81 Pain Relevance 0.14
In the absence of PKA inhibitors, isoproterenol increased the phosphorylation state of CREB within 5 min returning to basal after 60 min (n = 3).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
11) Confidence 0.39 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.12 Pain Relevance 0.06
In our experiments, the isoproterenol induced phosphorylation state of CREB was observed over a 2 hr interval (Figure 7).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
12) Confidence 0.39 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.07 Pain Relevance 0.03
Treating animals several days after the period of alcohol exposure with a phosphodiesterase type 1 inhibitor (Vinpocetine) increased CREB phosphorylation and restored orientation selectivity columns and neuronal orientation tuning.


Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB in neuronal associated with alcohol
13) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2721629 Disease Relevance 0.07 Pain Relevance 0.21
These redox modulations lead to a cascade of downstream events, such as phosphorylation and activation of ERK (extracellular signal-regulated kinase), PKC (protein kinase C), and CREB (cAMP-responsive element-binding protein), all of which are indispensable for LTP and synaptic plasticity (English and Sweatt, 1997; Klann et al., 1998; Knapp and Klann, 2002; Silva, 2003; Hidalgo, 2005; Kemmerling et al., 2007).


Positive_regulation (activation) of Phosphorylation (phosphorylation) of CREB associated with kinase c and long-term potentiation
14) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.57 Pain Relevance 0.20
Thus, it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi-K channel opening-coupled upregulation of CK2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
Positive_regulation (resultant) of Phosphorylation (phosphorylation) of CREB
15) Confidence 0.32 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.35 Pain Relevance 0.03
M Rp-cAMPS significantly blocked the isoproterenol mediated CREB phosphorylation (n = 3).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CREB
16) Confidence 0.28 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.14 Pain Relevance 0.09
CREB is a well characterized transcriptional factor, which is activated by cAMP-dependent PKA phosphorylation of specific serine residues [16].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of CREB
17) Confidence 0.28 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.07 Pain Relevance 0.04
Cilostazol suppressed TNF-alpha-induced decrease in viability of SK-N-SH (human neuroblastoma) cells and HCN-1A (human cortical neuron) cells in association with decrease in PTEN phosphorylation and increase in Akt/CREB phosphorylation with suppression of DNA fragmentation, all of which were antagonized by iberiotoxin, a maxi-K(+) channel blocker.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of CREB in SK-N-SH associated with neuroblastoma
18) Confidence 0.23 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.62 Pain Relevance 0.10
Thus, it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi-K channel opening-coupled upregulation of CK2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
19) Confidence 0.21 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.35 Pain Relevance 0.03
This opens new perspectives for a more mechanistic approach to the cellular signaling pathways of memory, for example with the use of phosphodiesterase IV inhibitors increasing CREB phosphorylation (Nagakura et al 2002; Tully et al 2003).
Positive_regulation (increasing) of Phosphorylation (phosphorylation) of CREB
20) Confidence 0.19 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654526 Disease Relevance 0.48 Pain Relevance 0.04

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