INT87282

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2008
Negated 5
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 7.61
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
colon 2
lung 1
endometrium 1
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 98.86 Very High Very High Very High
opioid receptor 3 97.16 Very High Very High Very High
Opioid 5 96.48 Very High Very High Very High
tolerance 1 96.20 Very High Very High Very High
cocaine 9 96.12 Very High Very High Very High
Physical dependence 1 95.64 Very High Very High Very High
MU agonist 1 92.56 High High
addiction 2 90.04 High High
Inflammation 10 86.72 High High
Delta opioid receptors 1 79.88 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 148 99.60 Very High Very High Very High
Colon Cancer 66 99.42 Very High Very High Very High
Lung Injury 9 99.32 Very High Very High Very High
Drug Dependence 1 95.64 Very High Very High Very High
Nerve Sheath Neoplasms 66 94.36 High High
Watson Syndrome 57 91.96 High High
Cancer 95 91.80 High High
Injury 5 89.36 High High
Bordatella Infection 1 89.32 High High
Pressure And Volume Under Development 2 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DESIGN: ERK1/2 phosphorylation and expression throughout the menstrual cycle were evaluated in vivo in normal and endometriotic human endometrium, and in vitro techniques assessed the steroidal regulation of ERK1/2 and its effect on endometrial cell survival.
Regulation (regulation) of ERK1 in endometrium
1) Confidence 0.60 Published 2008 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 18559923 Disease Relevance 0 Pain Relevance 0
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Regulation (Regulation) of ERK1 associated with opioid receptor
2) Confidence 0.44 Published 2000 Journal J. Neurochem. Section Title Doc Link 10737627 Disease Relevance 0.18 Pain Relevance 0.62
OBJECTIVE: We sought to determine ERK1/2 activity in patients with endometriosis and its possible roles in regulating endometrial cell survival.
Spec (possible) Regulation (roles) of ERK1
3) Confidence 0.44 Published 2008 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 18559923 Disease Relevance 0 Pain Relevance 0
These results indicate that sulindac metabolites modulate ERK1/2 and PKG pathways independently in colon cancer cells and suggest that the full apoptotic effect of sulindac is mediated by more than one pathway.
Neg (independently) Regulation (modulate) of ERK1 in colon associated with colon cancer and apoptosis
4) Confidence 0.44 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.81 Pain Relevance 0.05
Cotreatment with U0126 and YC-1 synergistically increases apoptosis in colorectal cancer cells and recapitulates the effects of sulindac treatment on ERK1/2, JNK, and beta-catenin.
Regulation (effects) of ERK1 associated with colon cancer and apoptosis
5) Confidence 0.26 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.99 Pain Relevance 0.11
The purpose of this study was to determine if PKG, ERK1/2, JNK, and beta-catenin are independent targets for sulindac in vitro.
Neg (independent) Regulation (targets) of ERK1
6) Confidence 0.26 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.01 Pain Relevance 0.15
However, these pharmacological studies have not been able to determine the specific role of the two predominant isoforms of ERK (ERK1 and ERK2) in these processes.
Spec (determine) Regulation (role) of ERK1
7) Confidence 0.20 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407894 Disease Relevance 0.07 Pain Relevance 0.35
No changes in basal ERK1/2 levels were observed (Fig. 5a).
Neg (No) Regulation (changes) of ERK1
8) Confidence 0.12 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.33 Pain Relevance 0
Matot and colleagues [25] evaluated MAPK activation in the reperfused lung, comparing the effects of the highly selective A3AR agonist MRS3558 with that of the moderately selective agonist IB-MECA on lung injury and apoptosis and determined the modulation of MAPK (ERK1, ERK2, p38, and JNK) pathways after A3AR activation in a feline model of lung I/R.
Spec (determined) Regulation (modulation) of ERK1 in lung associated with lung injury, agonist and apoptosis
9) Confidence 0.09 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.17 Pain Relevance 0.37
In addition, no effects on RAS-GTP and phospho-ERK1/2 levels by Sulindac derivatives were observed in the presence of EGF.
Neg (no) Regulation (effects) of ERK1
10) Confidence 0.09 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.82 Pain Relevance 0
Basal ERK1/2 levels were not affected by the treatment, thus excluding cytotoxic effects of the drugs and demonstrating specific effects on the RAS-ERK activation cascade during MPNST-cell growth inhibition.
Neg (not) Regulation (affected) of ERK1 associated with nerve sheath neoplasms
11) Confidence 0.05 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.08 Pain Relevance 0
Interestingly, an early study reported that the enzymatic activity of ERK1/ERK2 is markedly up-regulated during late progression of carcinogen-induced colon carcinomas [61].
Regulation (regulated) of ERK1 in colon associated with colon cancer
12) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 1.13 Pain Relevance 0

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