INT87284

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.65
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 99.82 Very High Very High Very High
dexamethasone 1 99.40 Very High Very High Very High
cINOD 16 98.94 Very High Very High Very High
COX-2 inhibitor 6 98.62 Very High Very High Very High
Cannabinoid receptor 32 83.04 Quite High
agonist 6 78.28 Quite High
opioid receptor 6 75.00 Quite High
Osteoarthritis 89 73.68 Quite High
rheumatoid arthritis 99 73.40 Quite High
Enkephalin 2 71.08 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 46 99.70 Very High Very High Very High
INFLAMMATION 37 98.82 Very High Very High Very High
Targeted Disruption 5 95.60 Very High Very High Very High
Hyperplasia 2 95.04 Very High Very High Very High
Apoptosis 47 94.68 High High
Cancer 56 89.44 High High
Hepatocellular Cancer 6 88.20 High High
Liver Cancer 1 75.00 Quite High
Frailty 90 73.68 Quite High
Rheumatoid Arthritis 99 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, our results show that although Gz mediated opioid-induced inhibition of adenylyl cyclase and activation of ERK1/2, Gz alone was insufficient to mediate opioid-induced adenylyl cyclase supersensitization.
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK1 associated with opioid
1) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0 Pain Relevance 0.58
Both Gi and Gz mediated DPDPE-induced activation of ERK1/2, but these responses were abolished by chronic opioid treatment.
Negative_regulation (abolished) of Positive_regulation (activation) of ERK1 associated with opioid
2) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.05 Pain Relevance 0.66
Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK1 associated with inflammation, cinod and dexamethasone
3) Confidence 0.41 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.21
Treatment with COX-1 and COX-2 inhibitors in the presence of the selective MEK1/2 inhibitor U0126 effectively suppressed ERK1/2 activation and combinations of either SC-560 or CAY10404 with U0126 resulted in synergistic effects on cell growth inhibition and induction of apoptosis.
Negative_regulation (suppressed) of Positive_regulation (activation) of ERK1 associated with cox-2 inhibitor and apoptosis
4) Confidence 0.41 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.79 Pain Relevance 0.49
The effect of PTX was significant for p38 activation after a 10-minute stimulation with HU210 (P < 0.05); although PTX showed a tendency to decrease HU210-induced activation of ERK1 and ERK2, significance was not reached.
Negative_regulation (decrease) of Positive_regulation (activation) of ERK1
5) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.53 Pain Relevance 0.45
Under serum-free conditions a significant reduction of phospho-ERK1/2 activation was detected already after 8 h of treatment (data not shown).
Negative_regulation (reduction) of Positive_regulation (activation) of ERK1
6) Confidence 0.08 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.33 Pain Relevance 0
Colorectal cancers often display activation of the ERK1/2 MAP kinase pathway and therefore represent potential targets for MEK1/2 inhibitors [26].
Negative_regulation (inhibitors) of Positive_regulation (activation) of ERK1 associated with colon cancer
7) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.79 Pain Relevance 0

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