INT87285

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Context Info
Confidence 0.02
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CDCP1) plasma membrane (CDCP1)
CDCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 91.92 High High
Enkephalin 1 90.52 High High
Osteoarthritis 50 89.84 High High
opioid receptor 3 86.12 High High
Delta opioid receptors 1 83.56 Quite High
Opioid 5 82.80 Quite High
MU agonist 1 70.60 Quite High
Physical dependence 1 67.68 Quite High
tolerance 1 66.72 Quite High
cytokine 8 53.60 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 51 89.84 High High
Bordatella Infection 1 73.60 Quite High
Drug Dependence 1 67.68 Quite High
Cancer 1 10.00 Low Low
Necrosis 1 9.44 Low Low
Rheumatic Diseases 1 7.12 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, the activities of adenylyl cyclase, cyclic AMP (cAMP)-dependent response element-binding proteins (CREBs), and MAPKs were measured by determining cAMP accumulation and phosphorylation of CREBs and the extracellular signal-regulated protein kinases (ERKs) 1 and 2.
Positive_regulation (accumulation) of Phosphorylation (phosphorylation) of kinases
1) Confidence 0.02 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.14 Pain Relevance 0.70
As shown by western blot analysis of the cell extracts, incubation of cells for a short period of time with ET-1 results in the phosphorylation of p38 MAP, p44/42, SAP/JNK and Akt kinases.
Positive_regulation (results) of Phosphorylation (phosphorylation) of kinases
2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.09 Pain Relevance 0.04
was able to induce phosphorylation of all three kinases analyzed in lbpva55 cells and HPCs (data not shown).
Positive_regulation (induce) of Phosphorylation (phosphorylation) of kinases
3) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.03

General Comments

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