INT87288

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.62
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
DRG 2
HEK 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 8 100.00 Very High Very High Very High
mu opioid receptor 1 99.98 Very High Very High Very High
dorsal root ganglion 4 99.24 Very High Very High Very High
Opioid 12 98.82 Very High Very High Very High
5HT 6 94.20 High High
antagonist 1 93.92 High High
Stimulus evoked pain 3 93.44 High High
agonist 2 88.20 High High
qutenza 4 83.28 Quite High
Serotonin 3 81.40 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 98.76 Very High Very High Very High
Nerve Sheath Neoplasms 22 95.76 Very High Very High Very High
Hypersensitivity 3 93.44 High High
Pain 4 92.76 High High
Apoptosis 37 83.44 Quite High
Watson Syndrome 19 65.80 Quite High
Cancer 16 55.20 Quite High
Bordatella Infection 1 55.08 Quite High
Drug Dependence 1 49.16 Quite Low
Reprotox - General 1 2 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both Gi and Gz mediated DPDPE-induced activation of ERK1/2, but these responses were abolished by chronic opioid treatment.
Positive_regulation (mediated) of Positive_regulation (activation) of ERK1 associated with opioid
1) Confidence 0.67 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.06 Pain Relevance 0.65
Recently, we have reported that the phosphorylation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) occurs in primary afferent neurons in response to noxious stimulation of the peripheral tissue, i.e., activity-dependent activation of ERK1/2 and p38 MAPK in dorsal root ganglion (DRG) neurons.
Positive_regulation (occurs) of Positive_regulation (activation) of ERK1 in DRG associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17237256 Disease Relevance 0.69 Pain Relevance 0.50
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Positive_regulation (fluoxetine-induced) of Positive_regulation (activation) of ERK1 associated with fluoxetine
3) Confidence 0.49 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.18
Acute opioid treatment of HEK 293 cells expressing mu-opioid receptors resulted in the activation of ERK1/2, and this response was abolished in the presence of U0126, a MEK1/2 inhibitor.
Positive_regulation (resulted) of Positive_regulation (activation) of ERK1 in HEK associated with mu opioid receptor and opioid
4) Confidence 0.45 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.71
Apparently, activation of ERK1/2 by EGF stimulation was independent of increased RAS-GTP levels.
Neg (independent) Positive_regulation (independent) of Positive_regulation (activation) of ERK1
5) Confidence 0.10 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.88 Pain Relevance 0

General Comments

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