INT87297

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Context Info
Confidence 0.11
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 2.72
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PSD3) intracellular (PSD3) cytoplasm (PSD3)
Anatomy Link Frequency
colon 4
HT-29 1
PSD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 26 99.32 Very High Very High Very High
COX2 10 98.94 Very High Very High Very High
aspirin 5 93.08 High High
COX-2 inhibitor 4 90.72 High High
Spinal cord 1 59.28 Quite High
Potency 8 47.64 Quite Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 10 99.84 Very High Very High Very High
Apoptosis 15 99.80 Very High Very High Very High
INFLAMMATION 6 99.04 Very High Very High Very High
Cancer 6 98.56 Very High Very High Very High
Reprotox - General 1 1 89.92 High High
Targeted Disruption 1 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NS-398 completely inhibited proliferation, induced G1 arrest and promoted apoptosis in COX-2-expressing cells (HT29.Fu and HCA-7).
Gene_expression (expressing) of HCA-7 associated with apoptosis
1) Confidence 0.11 Published 2000 Journal Eur. J. Cancer Section Abstract Doc Link 10738133 Disease Relevance 0.73 Pain Relevance 0.64
For instance, meloxicam inhibits the growth of cultured colon cancer cells (HCA-7 and Moser-S) that express COX-2 but has no effect on HCT-116 tumor cells that do not express COX-2.
Gene_expression (express) of HCA-7 in colon associated with cancer and colon cancer
2) Confidence 0.02 Published 2000 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 11078056 Disease Relevance 0.93 Pain Relevance 0.46
The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
Gene_expression (expressing) of HCA-7 in colon associated with inflammation, colon cancer and cinod
3) Confidence 0.00 Published 2009 Journal Pathol. Oncol. Res. Section Abstract Doc Link 19048402 Disease Relevance 0.27 Pain Relevance 0.20
The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
Gene_expression (expressing) of HCA-7 in colon associated with inflammation, colon cancer and cinod
4) Confidence 0.00 Published 2009 Journal Pathol. Oncol. Res. Section Abstract Doc Link 19048402 Disease Relevance 0.27 Pain Relevance 0.20
The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
Spec (investigated) Gene_expression (-) of HCA-7 in colon associated with inflammation, colon cancer and cinod
5) Confidence 0.00 Published 2009 Journal Pathol. Oncol. Res. Section Abstract Doc Link 19048402 Disease Relevance 0.27 Pain Relevance 0.20
Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
Gene_expression (expressing) of HCA-7 in HT-29 associated with cox2
6) Confidence 0.00 Published 2009 Journal Pathol. Oncol. Res. Section Title Doc Link 19048402 Disease Relevance 0.26 Pain Relevance 0.28

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