INT873

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Context Info
Confidence 0.76
First Reported 1975
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 130
Total Number 150
Disease Relevance 26.15
Pain Relevance 46.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 20
pituitary 11
somatotrophs 5
hypothalamus 5
Pit 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 993 100.00 Very High Very High Very High
agonist 755 100.00 Very High Very High Very High
Clonidine 212 100.00 Very High Very High Very High
Morphine 102 100.00 Very High Very High Very High
opiate 34 99.98 Very High Very High Very High
substance P 405 99.96 Very High Very High Very High
Somatostatin 731 99.84 Very High Very High Very High
narcan 46 99.84 Very High Very High Very High
methadone 39 99.78 Very High Very High Very High
gABA 367 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenoma 120 99.96 Very High Very High Very High
Stress 1285 99.84 Very High Very High Very High
Sepsis 152 99.84 Very High Very High Very High
Hypotension 32 99.80 Very High Very High Very High
INFLAMMATION 974 99.52 Very High Very High Very High
Rheumatoid Arthritis 516 99.46 Very High Very High Very High
Acromegaly 520 99.28 Very High Very High Very High
Thyroid Disease 134 99.26 Very High Very High Very High
Starvation 260 99.18 Very High Very High Very High
Obesity 165 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition they suggest that impairment of GH secretion in thyroidectomized rats does not depend upon changes in the hypothalamic SRIF regulation of the hormone but could be dependent on a defect in GRF release and/or, most probably, GH synthesis directly at the pituitary level.
Gene_expression (synthesis) of GH in pituitary associated with somatostatin
1) Confidence 0.76 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0 Pain Relevance 0.28
In eight-day-old pups, yohimbine prevented the nursing-induced increase in serum GH and decreased GH levels below the saline-injected, separated control.
Gene_expression (levels) of GH
2) Confidence 0.67 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.44
MSG-treated animals which were administered antisomatostatin serum showed elevated GH trough and mean GH levels, with no apparent effect on GH peak levels.
Gene_expression (levels) of GH
3) Confidence 0.67 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.21 Pain Relevance 0.15
Mean 5-h plasma GH levels were reduced, whereas PRL levels were not affected.
Gene_expression (levels) of GH in plasma
4) Confidence 0.67 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.25 Pain Relevance 0.17
MSG-treated animals which were administered antisomatostatin serum showed elevated GH trough and mean GH levels, with no apparent effect on GH peak levels.
Gene_expression (trough) of GH
5) Confidence 0.67 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.21 Pain Relevance 0.15
In the rats neonatally treated with MSG (4 mg/g body weight, s.c.), which causes selective destruction of the hypothalamic arcuate nucleus, plasma GH response to clonidine as well as the spontaneous GH bursts were considerably blunted, whereas prostaglandin E1 (5 micrograms/100 g body weight, i.v.) caused an abrupt increase in plasma GH levels in these animals.
Gene_expression (levels) of GH in plasma associated with glutamate, body weight and clonidine
6) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.27 Pain Relevance 0.58
Increased plasma CS was found after 1 and 2 weeks of injections and decreased GH levels were present after 2 and 6 weeks.
Gene_expression (present) of GH in plasma
7) Confidence 0.65 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1234768 Disease Relevance 0 Pain Relevance 0.60
The effect of testosterone on the growth hormone (GH)-releasing and hypotensive actions of clonidine was evaluated in vivo using male Wistar rats.
Gene_expression (-releasing) of GH associated with hypotension and clonidine
8) Confidence 0.65 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.30 Pain Relevance 0.57
Clonidine at various doses and by various routes (5 micrograms/kg, i.c.v.; 15 micrograms/kg, i.v., and 7, 15, 31, 125 and 250 micrograms/kg, i.p.) induced a significant increase in plasma GH levels in rats.
Gene_expression (levels) of GH in plasma associated with clonidine
9) Confidence 0.65 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.33 Pain Relevance 0.70
Plasma GH levels were significantly elevated in rats with hypothalamic cuts such as complete deafferentiation, anterior cut and antero-lateral cut, whereas plasma GH levels in rats with posterior cut or postero-lateral cut were not significantly different from those in rats with sham-operation.
Gene_expression (levels) of GH in lateral
10) Confidence 0.65 Published 1975 Journal Endocrinol. Jpn. Section Abstract Doc Link 1097237 Disease Relevance 0 Pain Relevance 0
The demonstration that GH-releasing factor (GRF) stimulates GH synthesis and release in rat pups prompted studies to evaluate the effects on the same indices of clonidine (CLO), an alpha 2-adrenoceptor and potent GH secretagogue, purported to act in adult rats via GRF release.
Gene_expression (synthesis) of GH associated with clonidine
11) Confidence 0.65 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.53
Both GRF and CLO stimulate GH synthesis when administered repeatedly.
Gene_expression (synthesis) of GH associated with clonidine
12) Confidence 0.65 Published 1986 Journal Endocrinology Section Abstract Doc Link 3089765 Disease Relevance 0 Pain Relevance 0.68
Direct injection of clonidine (0.1 microgram/microliters) into the PVN significantly stimulated GH secretion, whereas injection of isoproterenol (2.5 micrograms/microliters) into the PVN did not affect GH levels when compared to controls.
Gene_expression (levels) of GH in PVN associated with clonidine
13) Confidence 0.64 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1361032 Disease Relevance 0.06 Pain Relevance 0.51
It is evident that the expression of GH and IGF-I receptors is area-specific in the TMJ.
Gene_expression (expression) of GH in TMJ associated with snapping jaw
14) Confidence 0.62 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11706949 Disease Relevance 0.41 Pain Relevance 0.41
In contrast, injection of clonidine at trough times (when SRIF tone is high) consistently augmented plasma GH levels (mean +/- S.E.M. integrated GH release; 30 micrograms/kg, 1843.0 +/- 484.0; 50 micrograms/kg, 1469.0 +/- 490.3; 125 micrograms/kg, 1675.6 +/- 513.4 vs 201.3 +/- 100.1 ng/ml per 45 min in saline-injected controls; p < 0.05 or less).
Gene_expression (levels) of GH in plasma associated with somatostatin and clonidine
15) Confidence 0.62 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7913948 Disease Relevance 0 Pain Relevance 0.98
It has previously been described that the growth hormone (GH) releasing effect of clonidine (CLO), an agonist of alpha2-adrenoreceptors, disappears after orchidectomy and is restored by testosterone replacement when started immediately after orchidectomy.
Gene_expression (disappears) of GH associated with agonist and clonidine
16) Confidence 0.61 Published 1996 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 8918979 Disease Relevance 0 Pain Relevance 0.48
Preinjection of 20 micrograms oGH in proestrous or diestrous animals or 30 micrograms oGH in diestrous animals 3 h before CLON treatment did not depress plasma GH levels below those found in animals receiving CLON alone.
Gene_expression (levels) of GH in plasma associated with clonidine
17) Confidence 0.60 Published 1989 Journal Endocrinology Section Abstract Doc Link 2571494 Disease Relevance 0 Pain Relevance 1.15
However, preinjected oGH lowered basal GH levels but failed to suppress the CLON-induced GH surge.
Gene_expression (levels) of GH associated with clonidine
18) Confidence 0.60 Published 1989 Journal Endocrinology Section Abstract Doc Link 2571494 Disease Relevance 0 Pain Relevance 1.35
Circulating GH levels were significantly decreased following a brief (2 min) exposure to either, during repetitive etherization coupled with blood withdrawal, and during continuous immobilization.
Gene_expression (levels) of GH in blood associated with withdrawal
19) Confidence 0.60 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6473349 Disease Relevance 0.38 Pain Relevance 0.52
Pulsatile administration of GH (40 micrograms/day/rat, with successive periods of 2 h of GH and 4 h of mineral oil) restoring the endogenous GH-secretory pattern throughout the 15-day period of arthritis development prevents hindpaw diameter increase.
Gene_expression (administration) of GH associated with arthritis
20) Confidence 0.60 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.89 Pain Relevance 0.74

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