INT87301

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.98
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal 2
HPC 1
neural 1
hpc (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 66 100.00 Very High Very High Very High
Hippocampus 47 100.00 Very High Very High Very High
Nucleus accumbens 182 99.64 Very High Very High Very High
amygdala 14 92.60 High High
gABA 10 89.20 High High
Dopamine 246 86.32 High High
Neurotransmitter 29 75.56 Quite High
Glutamate receptor 5 70.36 Quite High
Paracetamol 1 60.52 Quite High
Eae 21 50.88 Quite High
Disease Link Frequency Relevance Heat
Stress 109 98.78 Very High Very High Very High
Anxiety Disorder 14 68.16 Quite High
Urological Neuroanatomy 6 66.72 Quite High
Cognitive Disorder 69 50.88 Quite High
Attention Deficit Hyperactivity Disorder 7 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Handedness 3 5.00 Very Low Very Low Very Low
Burns 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCTZ has a greater tendency to interact with HPC in the filter than other active ingredients tested.
HPC Binding (interact) of
1) Confidence 0.48 Published 2000 Journal Drug Dev Ind Pharm Section Abstract Doc Link 10738651 Disease Relevance 0 Pain Relevance 0.06
Collectively, these results suggest that the OFC and HPC contribute to an extended neural circuitry underlying intertemporal choice, cost-benefit decision making, which presumably also includes brain areas such as the nucleus accumbens and basolateral amygdala (Cardinal, Pennicott, Sugathapala, Robbins, & Everitt, 2001; Pothuizen, Jongen-Relo, Feldon, & Yee, 2005; Winstanley, Theobald, Cardinal, & Robbins, 2004).
HPC Binding (contribute) of in neural associated with nucleus accumbens and amygdala
2) Confidence 0.08 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.14 Pain Relevance 0.18
There is good evidence that performance on spatial tasks depends on functional interaction between the HPC and the NAc (e.g., Floresco & Phillips, 1999; Ito et al., 2008).
HPC Binding (interaction) of in HPC associated with nucleus accumbens and hippocampus
3) Confidence 0.04 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.73
Although the HPC has been characterized by a functional gradient along the dorsoventral axis, with the dorsal HPC being more important for spatial memory (e.g., Moser, Moser, & Andersen, 1993; Pothuizen, Zhang, Jongen-Relo, Feldon, & Yee, 2004), recent evidence has highlighted a critical role for the intermediate HPC in rapid place learning and its translation into behavioral performance, perhaps via its connections with the medial shell and prefrontal cortex (Bast, 2007; Bast, Wilson, Witter, & Morris, 2009).
HPC Binding (connections) of in dorsal associated with hippocampus
4) Confidence 0.04 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.76
Although the HPC has been characterized by a functional gradient along the dorsoventral axis, with the dorsal HPC being more important for spatial memory (e.g., Moser, Moser, & Andersen, 1993; Pothuizen, Zhang, Jongen-Relo, Feldon, & Yee, 2004), recent evidence has highlighted a critical role for the intermediate HPC in rapid place learning and its translation into behavioral performance, perhaps via its connections with the medial shell and prefrontal cortex (Bast, 2007; Bast, Wilson, Witter, & Morris, 2009).
HPC Binding (connections) of in dorsal associated with hippocampus
5) Confidence 0.04 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.05 Pain Relevance 0.89
Moreover, recent work has shown that acute stress may rapidly increase the level of circulating CORT that, by binding to membrane-located MR and rapid non-transcriptional action, induces the release of glutamate in HPC [11], [12], [29].
HPC Binding (binding) of associated with stress and glutamate
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.79 Pain Relevance 0.32

General Comments

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