INT87303

Context Info Confidence 0.54 First Reported 2000 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 7 Total Number 7 Disease Relevance 1.32 Pain Relevance 0.93

extracellular space (Cxcl1) extracellular region (Cxcl1)

Anatomy Link Frequency blood 2 IB4 2 neutrophil 2 Cxcl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 34 100.00 Dopamine 1 96.96 Inflammation 63 95.58 chemokine 49 93.52 Inflammatory mediators 11 91.04 metalloproteinase 29 87.80 Inflammatory response 7 79.36 Glutamate 2 62.00 Neuronal excitability 2 50.00 Analgesic 1 34.16

Disease Link Frequency Relevance Heat INFLAMMATION 77 95.58 Adhesions 3 84.64 Systemic Inflammatory Response Syndrome 5 68.44 Injury 18 64.32 Nociception 19 63.64 Infection 7 62.00 Disease 3 61.20 Wound Healing 2 54.80 Adult Respiratory Distress Syndrome 28 44.20 Sepsis 5 35.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of each CINC was regulated differently; the production of CINC-1 reached a maximum at 12 h and then slightly decreased after lipopolysaccharide stimulation, whereas that of CINC-2 and CINC-3 increased up to 24 h.

Regulation (regulated) of Gene_expression (Expression) of CINC

1) Confidence 0.54 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.07 Pain Relevance 0

Fucoidin had no effect on carrageenan-induced TNF-alpha, IL-1beta, and cytokine-induced neutrophil chemoattractant 1 (CINC-1)/CXCL1 production, suggesting that neutrophils were not the source of hypernociceptive cytokines.

Neg (no) Regulation (effect) of Gene_expression (production) of CXCL1 in neutrophil associated with cytokine

2) Confidence 0.45 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18203872 Disease Relevance 0.47 Pain Relevance 0.32

Once it had been well established that the proportion of IB4-positive cells did not change with GRO/KC exposure, IB4 binding was sometimes examined prior to recording in order to ensure that approximately equal numbers of each cell type were recorded in each experiment.

Neg (not) Regulation (change) of Gene_expression (exposure) of GRO/KC in IB4

3) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0

Hence a single efficiency value was used for control and GRO/KC samples for each gene in any given experiment.

Regulation (control) of Gene_expression (samples) of GRO/KC

4) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0

In contrast, CXCL1 gene expression induced by 2.5 µg PDGF encapsulated in low MW and high MW PLGA microspheres had no significant differences from either the NFS alone or PDGF coating groups, which indicates up-regulation of CXCL1 gene expression stimulated by PDGF is dependent on PDGF dose.

Regulation (regulation) of Gene_expression (expression) of CXCL1 gene

5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.18 Pain Relevance 0.36

CINC-1 levels rapidly increase after induction of inflammation in rats, especially 8 hrs after the injury35, and the levels reach concentrations significantly different from those of controls at 4, 8, and 24 hrs after LPS infusion in blood samples.37 The possible mechanism by which CINC-1 expression was modulated in this study remains to be determined.

Spec (possible) Regulation (modulated) of Gene_expression (expression) of CINC-1 in blood associated with inflammation

6) Confidence 0.18 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827707 Disease Relevance 0.52 Pain Relevance 0.12

CINC protein expression was undetectable in the samples of saline control animals, but was markedly increased by LPS treatment for 4 hours.

Regulation (undetectable) of Gene_expression (expression) of CINC protein

7) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.09 Pain Relevance 0.13

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