INT87315

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Context Info
Confidence 0.13
First Reported 2000
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
neuronal 2
neurons 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Hippocampus 1 99.56 Very High Very High Very High
cerebral cortex 2 98.92 Very High Very High Very High
Glutamate 3 91.76 High High
Somatostatin 2 91.72 High High
Dopamine 3 91.20 High High
adenocard 3 75.00 Quite High
dopamine receptor 1 70.56 Quite High
Glutamate receptor 1 65.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 16 99.30 Very High Very High Very High
Disease 8 97.00 Very High Very High Very High
Aids-related Complex 1 94.00 High High
Neurodegenerative Disease 2 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that decreased expression of enkephalin mRNA may be an early sign of neuronal dysfunction due to the Huntington's disease mutation.
Negative_regulation (decreased) of Transcription (expression) of enkephalin in neuronal associated with enkephalin and disease
1) Confidence 0.13 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.85 Pain Relevance 0.56
Both transgenic and knock-in mice, however, showed a marked decrease in the level of expression of enkephalin mRNA in striatal neurons without significant decreases in mRNAs encoding substance P, GAD65, or GAD67.
Negative_regulation (decrease) of Transcription (expression) of enkephalin in neurons associated with targeted disruption, enkephalin and substance p
2) Confidence 0.13 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.82 Pain Relevance 0.60
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Negative_regulation (reduced) of Transcription (expression) of enkephalin associated with enkephalin and substance p
3) Confidence 0.06 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.65

General Comments

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