INT87316

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.61
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gad2) Golgi apparatus (Gad2) plasma membrane (Gad2)
cytoplasm (Gad2)
Anatomy Link Frequency
soma 2
neurons 1
Purkinje cells 1
brains 1
synapses 1
Gad2 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Enkephalin 7 99.08 Very High Very High Very High
gABA 66 98.72 Very High Very High Very High
Pyramidal cell 78 98.60 Very High Very High Very High
interneuron 15 92.56 High High
Neurotransmitter 5 88.52 High High
Somatostatin 4 87.92 High High
GABAergic 69 65.44 Quite High
Central nervous system 1 60.76 Quite High
imagery 15 13.24 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 54 99.50 Very High Very High Very High
Congenital Anomalies 6 95.80 Very High Very High Very High
Sprains And Strains 6 87.56 High High
Convulsion 9 75.20 Quite High
Disease 4 75.00 Quite High
Frailty 7 73.44 Quite High
Neurodegenerative Disease 1 40.52 Quite Low
Increased Venous Pressure Under Development 3 8.04 Low Low
Adhesions 24 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of a total of 32 cells (from 4 mice) per group showed a significant decrease in GAD65 puncta number in dark reared mice compared to normal reared and light exposed animals (NR = 22.5 ± 2.2 GAD65 puncta/soma, DR = 13.6 ± 1.5 GAD65 puncta/soma, LE = 19.5 ± 1.5 GAD65 puncta/soma, n = 32 cells from 4 mice each group; one-way ANOVA: F(2, 93) = 6.724, P < .002; Figure 2(a)).

3.2.

Negative_regulation (decrease) of GAD65 in soma
1) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0
Interestingly, we show that the decrease in GAD65 puncta number by dark rearing is rather rapidly reversed by only 3 days of light exposure.
Negative_regulation (decrease) of GAD65
2) Confidence 0.50 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.38
At P40, there was a significant reduction of GAD65 density in GFAP-Cre::CHL1flx/flx mice compared to CHL1flx/flx controls (Figure 8D, 8F, and 8H; 27 ± 7%; p ?
Negative_regulation (reduction) of GAD65 density
3) Confidence 0.49 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.34 Pain Relevance 0
The decrease in GAD65 puncta by dark rearing is not likely a consequence of smaller soma size in the dark-reared mice, because the difference remained even when GAD65 puncta number was normalized to soma size.
Negative_regulation (decrease) of GAD65 in soma
4) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.08
Both transgenic and knock-in mice, however, showed a marked decrease in the level of expression of enkephalin mRNA in striatal neurons without significant decreases in mRNAs encoding substance P, GAD65, or GAD67.
Negative_regulation (decreases) of GAD65 in neurons associated with targeted disruption, enkephalin and substance p
5) Confidence 0.39 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.79 Pain Relevance 0.57
We also deleted CHL1 in Purkinje cells by breeding CHL1flx mice with the L7-Cre transgenic mice [35]; there was no reduction of GAD65 density at P40 (Figure 8G and 8H), suggesting that CHL1 in Purkinje cells, if any, was not involved in the development of stellate synapses.
Neg (no) Negative_regulation (reduction) of GAD65 density in Purkinje cells associated with targeted disruption
6) Confidence 0.36 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.32 Pain Relevance 0
The significant reduction of GAD65 puncta in the ML may result from a reduction in the number of stellate synapses, deficient synapses, or both.
Negative_regulation (reduction) of GAD65 in synapses
7) Confidence 0.36 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
As well, GABA is thought to have significant effects on cell migration, differentiation, and synaptogenesis, yet fetal brains of mice lacking both GAD65 and GAD67 have 0.02% of normal GABA content and die at birth, but they have no obvious structural brain abnormalities [15].
Negative_regulation (lacking) of GAD65 in brains associated with gaba and congenital anomalies
8) Confidence 0.22 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.17 Pain Relevance 0.50

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