INT8732

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 76
Total Number 78
Disease Relevance 22.59
Pain Relevance 58.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 12
DRG 9
mesencephalon 5
brain structures 4
joints 4
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 1170 100.00 Very High Very High Very High
Opioid 868 100.00 Very High Very High Very High
mu opioid receptor 775 100.00 Very High Very High Very High
Morphine 683 100.00 Very High Very High Very High
agonist 259 100.00 Very High Very High Very High
Enkephalin 95 100.00 Very High Very High Very High
Nerve growth factor 40 100.00 Very High Very High Very High
Neuropathic pain 35 100.00 Very High Very High Very High
Rostral ventromedial medulla 11 100.00 Very High Very High Very High
Inflammation 376 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 53 100.00 Very High Very High Very High
INFLAMMATION 391 99.98 Very High Very High Very High
Ganglion Cysts 234 99.90 Very High Very High Very High
Neuroblastoma 24 99.84 Very High Very High Very High
Convulsion 8 99.82 Very High Very High Very High
Urological Neuroanatomy 138 99.68 Very High Very High Very High
Herpes Simplex Virus 26 99.54 Very High Very High Very High
Repression 68 99.52 Very High Very High Very High
Stress 107 99.50 Very High Very High Very High
Targeted Disruption 213 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.
Positive_regulation (mediated) of Gene_expression (transfer) of mu-opioid receptor associated with opioid receptor and analgesia
1) Confidence 0.70 Published 2008 Journal Anesthesiology Section Title Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.61
The current study used a recombinant herpes simplex virus type 1 to increase expression of the mu-opioid receptor (muOR) in primary afferent neurons.
Positive_regulation (increase) of Gene_expression (expression) of mu-opioid receptor in afferent neurons associated with herpes simplex virus and opioid receptor
2) Confidence 0.70 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.58
A single administration of corticosterone significantly induced the expression of the mu-opioid receptor in the CRH-deficient mouse brainstem and also enhanced the analgesic effect of morphine.
Positive_regulation (induced) of Gene_expression (expression) of mu-opioid receptor in brainstem associated with medulla, analgesic, opioid receptor and morphine
3) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109741 Disease Relevance 0.06 Pain Relevance 1.19
Viral propagation in the sensory ganglion may induce mu-opioid receptor expression in Abeta fibers, which may be responsible for the inhibitory action of local opioids on mechanical allodynia in mice with herpetic pain.
Spec (may) Positive_regulation (induce) of Gene_expression (expression) of mu-opioid receptor in sensory ganglion associated with ganglion cysts, pain, allodynia, opioid receptor, herpes simplex virus infection, opioid and abeta
4) Confidence 0.69 Published 2008 Journal Neuroreport Section Abstract Doc Link 18521004 Disease Relevance 1.22 Pain Relevance 1.58
Conversely, antagonist-induced up-regulation does not require an increase in mu-opioid receptor synthesis and may entail conversion of receptors to an appropriate conformation to bind ligand, as well as changes in receptor trafficking.
Positive_regulation (increase) of Gene_expression (synthesis) of mu-opioid receptor associated with antagonist and opioid receptor
5) Confidence 0.66 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 0.84
CONCLUSION: Our results indicate that prophylactic therapy with MOR overexpression in joints can successfully prevent the development of pain, dysfunction, and histopathologic abnormalities in the joints in arthritis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MOR in joints
6) Confidence 0.57 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17530644 Disease Relevance 0 Pain Relevance 0
Phosphorylation of the mu-opioid receptor may play a role in opioid tolerance and dependence. 3-Isobutyl-1-methylxanthine (IBMX) was found to inhibit basal mu-opioid receptor phosphorylation (IC50 < or = 10 microM) either upon acute treatment or after 8 h pre-treatment in HEK293 cells transfected with the mu-opioid receptor.
Positive_regulation (transfected) of Gene_expression (transfected) of mu-opioid receptor associated with addiction, tolerance, opioid receptor and opioid
7) Confidence 0.50 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10355588 Disease Relevance 0 Pain Relevance 1.19
The current study used a recombinant herpes simplex virus type 1 to increase expression of the mu-opioid receptor (muOR) in primary afferent neurons.
Positive_regulation (increase) of Gene_expression (expression) of muOR in afferent neurons associated with herpes simplex virus and opioid receptor
8) Confidence 0.50 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.59
To investigate further the possible changes in MOR function to activate G-proteins under the condition of a reduced MOR-1B expression, the guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding assay was performed.
Positive_regulation (activate) of Gene_expression (expression) of MOR associated with opioid receptor
9) Confidence 0.50 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14686893 Disease Relevance 0.27 Pain Relevance 0.89
At the molecular level, our results suggest that these effects are not mediated by changes in MOR expression but by other changes in receptor activation/internalization.
Neg (not) Positive_regulation (mediated) of Gene_expression (expression) of MOR associated with opioid receptor
10) Confidence 0.50 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17468301 Disease Relevance 0.45 Pain Relevance 1.39
Flow cytometry analysis showed that adenoviral-mediated expression of the amino-terminal flag-tagged mu opioid receptor in neurons resulted in approximately 1.3x10(6) receptors/cell.
Positive_regulation (resulted) of Gene_expression (expression) of mu opioid receptor in neurons associated with mu opioid receptor
11) Confidence 0.49 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667446 Disease Relevance 0.25 Pain Relevance 0.53
Both radioligands labeled sites in CHO cells stably transfected with the mouse MOR-1 clone.
Positive_regulation (transfected) of Gene_expression (transfected) of MOR-1
12) Confidence 0.49 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16075389 Disease Relevance 0 Pain Relevance 0.26
METHODS: We induced human mu-opioid receptor (HuMOR) expression in arthritic joints of mice, using the feline immunodeficiency virus (FIV) vector, which is capable of stably transducing dividing, growth-arrested, and terminally differentiated cells.
Positive_regulation (induced) of Gene_expression (expression) of mu-opioid receptor in joints
13) Confidence 0.49 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17530644 Disease Relevance 0.10 Pain Relevance 0
Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.
Positive_regulation (transfer) of Gene_expression (transfer) of mu-opioid receptor associated with opioid receptor and analgesia
14) Confidence 0.47 Published 2008 Journal Anesthesiology Section Title Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.61
Several lines of evidence have suggested that the level of opioid-induced analgesia is dependent on the level of expression of the mu-opioid receptor (mu-OR).
Positive_regulation (dependent) of Gene_expression (expression) of mu-opioid receptor associated with opioid receptor, opioid and analgesia
15) Confidence 0.46 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11160404 Disease Relevance 0 Pain Relevance 0.75
Allelic variants that confer differing levels of MOR expression could provide different degrees of risk for alcoholism.


Positive_regulation (confer) of Gene_expression (expression) of MOR
16) Confidence 0.46 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11292005 Disease Relevance 0 Pain Relevance 0
Together with the increased exploratory activity we established in homozygous mice significantly increased expression of the Oprm1 gene in the frontal cortex and mesencephalon.
Positive_regulation (increased) of Gene_expression (expression) of Oprm1 gene in mesencephalon associated with urological neuroanatomy
17) Confidence 0.46 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.25 Pain Relevance 0.09
CP3 construct up-regulates endogenous human OPRM1 expression in human neuroblastoma NMB cells (30).
Positive_regulation (up-regulates) of Gene_expression (expression) of OPRM1 associated with neuroblastoma
18) Confidence 0.46 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.17 Pain Relevance 0.11
Western blot analysis was performed in order to confirm that MOR protein expression is increased in STOP null mice compared to wild type animals.
Positive_regulation (increased) of Gene_expression (expression) of MOR protein associated with mu opioid receptor
19) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.14 Pain Relevance 0.30
This effect of morphine is also mediated through the mu-opioid receptor present on the surface of macrophages.
Positive_regulation (mediated) of Gene_expression (present) of mu-opioid receptor in macrophages associated with opioid receptor and morphine
20) Confidence 0.46 Published 2001 Journal J. Leukoc. Biol. Section Abstract Doc Link 11590188 Disease Relevance 0.33 Pain Relevance 0.96

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