INT87320

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ngf, Bdnf) signal transduction (Ngf) extracellular space (Ngf)
aging (Ngf) cytoplasmic membrane-bounded vesicle (Bdnf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 2
Ngf (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 10 100.00 Very High Very High Very High
Nerve growth factor 9 100.00 Very High Very High Very High
Inflammatory response 1 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Neuritis 1 99.40 Very High Very High Very High
Dorsal horn neuron 1 97.36 Very High Very High Very High
allodynia 2 88.08 High High
Neuropathic pain 1 83.52 Quite High
trigeminal ganglion 1 60.08 Quite High
nociceptor 4 43.20 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 100.00 Very High Very High Very High
INFLAMMATION 2 100.00 Very High Very High Very High
Neuritis 1 99.40 Very High Very High Very High
Neuropathic Pain 3 88.08 High High
Pain 2 34.80 Quite Low
Nerve Root Compression 1 32.56 Quite Low
Congenital Anomalies 1 28.24 Quite Low
Nociception 1 27.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that most pulpal afferents in the adult express the NGF receptors p75(NTR) and trkA, and thus have a continuing potential susceptibility to NGF-mediated regulation of functions such as neuropeptide and BDNF synthesis.
NGF Regulation (regulation) of Gene_expression (synthesis) of BDNF associated with neuropeptide
1) Confidence 0.38 Published 2000 Journal Arch. Oral Biol. Section Abstract Doc Link 10739860 Disease Relevance 0.06 Pain Relevance 0.12
These findings suggest that in the lumbar disc herniation model, i.e. neuritis of the nerve root, increased NGF produced by the inflammatory responses in the dorsal root and DRG tissues may affect the production of BDNF in the DRG and may play important roles in the modulation of the dorsal horn neurons.
NGF Spec (may) Regulation (affect) of Gene_expression (production) of BDNF in nerve associated with dorsal root ganglion, inflammatory response, nerve growth factor, dorsal horn neuron and neuritis
2) Confidence 0.22 Published 2002 Journal Pain Section Abstract Doc Link 12237190 Disease Relevance 0.91 Pain Relevance 0.94

General Comments

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