INT87323

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 9.91
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
leukocytes 7
Lymphocytes 2
monocytes 1
neutrophils 1
respiratory 1
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 42 100.00 Very High Very High Very High
Onset of action 2 97.82 Very High Very High Very High
Inflammation 143 93.00 High High
Inflammatory response 29 91.60 High High
methotrexate 4 91.08 High High
aspirin 46 89.92 High High
cINOD 4 89.56 High High
Substantia nigra 49 89.44 High High
metalloproteinase 8 81.44 Quite High
chemokine 9 73.48 Quite High
Disease Link Frequency Relevance Heat
Adhesions 109 100.00 Very High Very High Very High
Pulmonary Disease 64 99.54 Very High Very High Very High
Death 51 99.04 Very High Very High Very High
Disease 197 97.88 Very High Very High Very High
Coronary Artery Disease 273 93.72 High High
INFLAMMATION 180 93.00 High High
Atherosclerosis 42 90.32 High High
Congenital Anomalies 1 89.84 High High
Increased Venous Pressure Under Development 2 89.04 High High
Blister 14 76.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphocytes from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic bound CD11a/CD18, CD11c/CD18, CD44 and CD62L mAbs was determined.
CD18 Binding (bound) of in Lymphocytes associated with adhesions
1) Confidence 0.47 Published 1999 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10740409 Disease Relevance 0.76 Pain Relevance 0.38
Lymphocytes from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic bound CD11a/CD18, CD11c/CD18, CD44 and CD62L mAbs was determined.
CD18 Binding (bound) of in Lymphocytes associated with adhesions
2) Confidence 0.47 Published 1999 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10740409 Disease Relevance 0.76 Pain Relevance 0.38
To confirm this observation, a further analysis was performed on the genes that interact with the beta 2 integrin gene (ITGB2) which showed evidence of positive selection along the rat (p < 0.001) and murid (p < 0.05) lineages.
ITGB2 Binding (interact) of
3) Confidence 0.29 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2576240 Disease Relevance 0 Pain Relevance 0
To confirm this observation, a further analysis was performed on the genes that interact with the beta 2 integrin gene (ITGB2) which showed evidence of positive selection along the rat (p < 0.001) and murid (p < 0.05) lineages.
2 integrin gene Binding (interact) of
4) Confidence 0.25 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2576240 Disease Relevance 0 Pain Relevance 0
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
Mac-1 Binding (bind) of in monocytes associated with adhesions
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.58 Pain Relevance 0.15
However, upon stimulation with C3bi-opsonised yeast, which binds and activates CD11b/CD18 [25], the ?
CD18 Binding (binds) of
6) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.74 Pain Relevance 0.03
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
CD18 Binding (Two) of in leukocytes associated with adhesions
7) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.87 Pain Relevance 0.05
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
CD18 Binding (belong) of in leukocytes associated with adhesions
8) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.80 Pain Relevance 0.07
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
LFA-1 Binding (Two) of in leukocytes associated with adhesions
9) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.87 Pain Relevance 0.05
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
LFA-1 Binding (belong) of in leukocytes associated with adhesions
10) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.80 Pain Relevance 0.07
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
CD18 Binding (receptor) of in leukocytes associated with adhesions
11) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.79 Pain Relevance 0.07
Two of the most important adhesion molecules, expressed exclusively by leukocytes, are CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1 or complement receptor 3), which belong to the ?
CD18 Binding (belong) of in leukocytes associated with adhesions
12) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.79 Pain Relevance 0.07
In this regard, particular attention has been directed at the physiological and pathological roles played by intercellular adhesion molecule (ICAM-1), a 76-114-kDa surface glycoprotein that has five extracellular immunoglobulin-like domains [11-14].Transmigration of leukocytes involves high-affinity binding of LFA-1 or Mac-1 on their surface to ICAM-1 expressed on the endothelium [10].
Mac-1 Binding (binding) of in leukocytes associated with adhesions
13) Confidence 0.07 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.49 Pain Relevance 0.21
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
Mac-1 Binding (bind) of in neutrophils associated with adhesions
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.58 Pain Relevance 0.15
A recent meta-analysis pooling data from 22 studies that compared anticholinergics and beta2-agonists concluded that inhaled anticholinergics, but not beta2-agonists significantly reduced severe exacerbations and respiratory deaths in COPD patients and that the beta2-agonists were associated with a greater risk of death and possible worsening disease control (Salpeter et al 2006).
beta2-agonists Binding (associated) of in respiratory associated with pulmonary disease, agonist, disease and death
15) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692120 Disease Relevance 0.48 Pain Relevance 0.15
The duration of action is approximately six hours so in comparison with beta2-agonists it has a slower onset of action, probably a longer duration of action, and does not cause tachyphylaxis or the drop in oxygenation that can occur with beta2-agonists (Karpal 1993).
beta2-agonists Binding (occur) of associated with onset of action and agonist
16) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692120 Disease Relevance 0.45 Pain Relevance 0.28
However, while Iba1 is implicated in Ca binding, Mac1 is an integrin that binds to multiple factors and acts as a subunit of Complement Receptor 3 [56], [57], [58].
Mac1 Binding (binds) of
17) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808388 Disease Relevance 0.14 Pain Relevance 0.15

General Comments

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