INT87329

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 10.85
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgax)
Anatomy Link Frequency
T cells 10
lung 8
N418 4
marginal zone 2
B cells 2
Itgax (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 105 98.36 Very High Very High Very High
vincristine 5 91.48 High High
Inflammation 102 83.84 Quite High
withdrawal 3 46.00 Quite Low
anesthesia 10 26.32 Quite Low
Pain 4 25.00 Low Low
chemokine 32 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Inflammatory marker 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 57 99.98 Very High Very High Very High
Infection 610 99.80 Very High Very High Very High
Mycobacterial Infection 290 99.56 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Leukemia 6 98.44 Very High Very High Very High
Respiratory Syncytial Virus 434 96.96 Very High Very High Very High
Neuropathic Pain 1 94.96 High High
Sprains And Strains 74 89.32 High High
B-cell Lymphoma 2 86.88 High High
Pneumonia 9 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD11c mRNA seems to be expressed constitutively in CD8+ T cells while expression of CD11c protein on the cell surface requires activation.
Positive_regulation (requires) of Gene_expression (expression) of CD11c in T cells
1) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.37 Pain Relevance 0.03
Again CD11c expression was much lower in MLN, spleen or blood and was not increased on CD3+CD8- cells (data not shown).
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CD11c in spleen
2) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.22 Pain Relevance 0.12
Interestingly, expression of CD11c was hardly increased on CD3+ CD8- cells (Figure 1a), consisting mostly of CD4+ T cells (data not shown).
Positive_regulation (increased) of Gene_expression (expression) of CD11c in T cells
3) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.90 Pain Relevance 0
The cells were stained with the following rat anti-mouse monoclonal antibodies: APC anti-CD11c (clone N418) and PE anti-NK 1.1 (clone PK136) from eBioscience; R-R-PE anti-CD8?
Positive_regulation (following) of Gene_expression (anti) of N418 in N418
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
Activation markers are expressed differentially on CD11c+ CD8+ and CD11c- CD8+ T cells
Positive_regulation (differentially) of Gene_expression (expressed) of CD11c in T cells
5) Confidence 0.46 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.79 Pain Relevance 0.10
CD11c+CD8+ or CD11c-CD8+ cells isolated by FACSDiva (Becton Dickinson) from lungs harvested on dpi 8, were adoptively transferred (2.5 × 105 cells per recipient) by intra-tracheal application 1 hour after RSV infection of recipient mice.
Positive_regulation (transferred) of Gene_expression (transferred) of CD11c in lungs associated with infection and respiratory syncytial virus
6) Confidence 0.46 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.48 Pain Relevance 0
Activation markers are expressed differentially on CD11c+ CD8+ and CD11c- CD8+ T cells
Positive_regulation (differentially) of Gene_expression (expressed) of CD11c in T cells
7) Confidence 0.46 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.79 Pain Relevance 0.10
CD11c+CD8+ or CD11c-CD8+ cells isolated by FACSDiva (Becton Dickinson) from lungs harvested on dpi 8, were adoptively transferred (2.5 × 105 cells per recipient) by intra-tracheal application 1 hour after RSV infection of recipient mice.
Positive_regulation (transferred) of Gene_expression (transferred) of CD11c in lungs associated with infection and respiratory syncytial virus
8) Confidence 0.46 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.48 Pain Relevance 0
We further suggest that exercise induces a microglial phenotype shift from a macrophagic phenotype to an antigen presenting phenotype, expressing CD11c and MHC II.
Positive_regulation (induces) of Gene_expression (expressing) of CD11c
9) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.76 Pain Relevance 0.05
The cells were stained with the following rat anti-mouse monoclonal antibodies: APC anti-CD11c (clone N418) and PE anti-NK 1.1 (clone PK136) from eBioscience; R-R-PE anti-CD8?
Positive_regulation (following) of Gene_expression (anti) of CD11c in N418
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
It should be noted that CD11c dendritic cells in bone marrow, as well as CD3+ T lymphocytes in spleen had increased in K?
Positive_regulation (increased) of Gene_expression (dendritic cells) of CD11c in T lymphocytes
11) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.07 Pain Relevance 0.03
Our specific gating strategy for Gr-1+ cells concentrated on cells that expressed high levels of Gr-1 and were also CD11b+ and CD11c-, which are suggestive of neutrophils [46]–[49] (data not shown).
Positive_regulation (levels) of Gene_expression (expressed) of CD11c in neutrophils
12) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 0.49 Pain Relevance 0.09
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of Neg (negative) Gene_expression (negative) of CD11C in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
13) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0
Phenotypic analysis by flow cytometric analysis on pre- and post-bryostatin 1-treated peripheral blood lymphocytes revealed up-regulation in the coexpression of CD11c/ CD22 on CD20+ B cells in two of four CLL patients studied, which is consistent with in vitro findings of differentiation of CLL cells to a hairy cell phenotype.
Positive_regulation (up-regulation) of Gene_expression (coexpression) of CD11c in B cells associated with leukemia
14) Confidence 0.09 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741703 Disease Relevance 0.63 Pain Relevance 0.21
Furthermore, we found there was increased expression of the transcripts encoding CD11b (Integrin alpha M-ITGAM) and CD11c (Integrin alpha X-ITGAX) in D21 M.tuberculosis-infected lung, but not at earlier time points (Table 2).
Positive_regulation (increased) of Gene_expression (expression) of CD11c in lung associated with mycobacterial infection and infection
15) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.33 Pain Relevance 0.11
Furthermore, we found there was increased expression of the transcripts encoding CD11b (Integrin alpha M-ITGAM) and CD11c (Integrin alpha X-ITGAX) in D21 M.tuberculosis-infected lung, but not at earlier time points (Table 2).
Positive_regulation (increased) of Gene_expression (expression) of Integrin alpha X-ITGAX in lung associated with mycobacterial infection and infection
16) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.39 Pain Relevance 0.11

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