INT8733

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 61
Total Number 66
Disease Relevance 7.55
Pain Relevance 64.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 5
dendrites 4
plasma 3
brain 3
spinal cord 3
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 1671 100.00 Very High Very High Very High
Morphine 1091 100.00 Very High Very High Very High
mu opioid receptor 634 100.00 Very High Very High Very High
gABA 47 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Endogenous opioid 25 100.00 Very High Very High Very High
Cholecystokinin 17 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 100.00 Very High Very High Very High
antagonist 92 99.98 Very High Very High Very High
Neurotransmitter 6 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 58 98.92 Very High Very High Very High
INFLAMMATION 31 98.72 Very High Very High Very High
Repression 23 98.52 Very High Very High Very High
Pain 92 98.28 Very High Very High Very High
Urological Neuroanatomy 140 98.20 Very High Very High Very High
Hypertrophy 2 96.60 Very High Very High Very High
Neurodegenerative Disease 32 95.28 Very High Very High Very High
Sprains And Strains 38 94.08 High High
Death 6 93.72 High High
Opiate Addiction 67 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of MOR immunoreactivity within the embryonic ventricular neuroepithelia is consistent with a role for opioids in modulating neurogenesis.
Localization (localization) of MOR associated with mu opioid receptor, neurodegenerative disease and opioid
1) Confidence 0.75 Published 2007 Journal Brain Res. Section Abstract Doc Link 17888889 Disease Relevance 0.10 Pain Relevance 0.56
However, the induction of MOR sensitization was not modified by any doses of MK-801, except for the case of combination of MOR (20 mg/kg) with MK-801 (1 mg/kg) which was highly toxic (i.e., eliciting death or a moribund condition).
Localization (sensitization) of MOR associated with death
2) Confidence 0.75 Published 1996 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 8640458 Disease Relevance 0.09 Pain Relevance 0.20
A second exposure to DAMGO (100 nM) following recovery of internalized muOR immunoreactivity at the cell surface induced a translocation of muOR immunoreactivity in the cytoplasm comparable to the one observed following the first exposure (46.89+/-3.11% versus 43.31+/-3.80%). muOR internalization was prevented by hyperosmolar sucrose, phenylarsine oxide or potassium depletion, which inhibit clathrin-mediated endocytosis. muOR recycling was prevented by pre-treatment with bafilomycin A1, an acidotropic agent that inhibits endosomal acidification, but not by the protein synthesis inhibitor, cycloheximide.
Localization (translocation) of muOR
3) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763066 Disease Relevance 0 Pain Relevance 0.45
These data indicate that mu-opioid receptor density, determined in radioligand binding assays, and immunoreactive dynamin-2 abundance are regulated by continuous, but not intermittent, opioid ligand treatment.
Localization (abundance) of mu-opioid receptor associated with opioid receptor and opioid
4) Confidence 0.72 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.09
This hypothesis is supported by the effects of alcohol on beta-endorphin release, of mu opioid receptor agonists and antagonists on alcohol consumption, and by the activation of the dopaminergic reward system by both alcohol and opiates.
Localization (release) of mu opioid receptor associated with antagonist, agonist, mu opioid receptor, opiate and alcohol
5) Confidence 0.71 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.15 Pain Relevance 0.94
Other mice were sacrificed at the end of the treatment and spinal cords were collected for determination of muOR density and GRK-2 and DYN-2 protein abundance.
Localization (abundance) of muOR density in spinal cords
6) Confidence 0.69 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12957235 Disease Relevance 0 Pain Relevance 1.13
These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance.
Localization (recycling) of MOR associated with tolerance, mu opioid receptor, kappa opioid receptor and morphine
7) Confidence 0.67 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.07 Pain Relevance 2.26
Regulation of MOR translation by uORF initiation
Localization (translation) of MOR associated with mu opioid receptor
8) Confidence 0.67 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.25 Pain Relevance 0.46
In the presence of beta-endorphin, the internalized mu-opioid receptor induced by fentanyl, but not oxycodone, remained within the cytosolic component even after washing out.
Localization (presence) of mu-opioid receptor associated with oxycodone and opioid receptor
9) Confidence 0.66 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108502 Disease Relevance 0.65 Pain Relevance 1.53
Marker information including genetic map position, location within OPRM1, and minor allele frequencies within this Indian population (as well as four reference populations for comparison) are listed in Table 1.
Localization (location) of OPRM1
10) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386778 Disease Relevance 0.13 Pain Relevance 0.13
Although chronic morphine treatment did not change overall MOR transcript, polysome-associated mRNA declined in a let-7-dependent manner. let-7 was identified as a mediator translocating and sequestering MOR mRNA to P-bodies, leading to translation repression.
Localization (translocating) of MOR mRNA associated with repression, mu opioid receptor and morphine
11) Confidence 0.65 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0.10 Pain Relevance 1.14
These results demonstrate that Mor-triggered release of inhibitory macrophage metabolites and decrement in soluble cytokines production are involved in the immunosuppressive effects caused by subchronic in vivo repetitive administrations of the drug of abuse.
Localization (release) of Mor in macrophage associated with cytokine and morphine
12) Confidence 0.57 Published 1996 Journal Brain Behav. Immun. Section Abstract Doc Link 9045750 Disease Relevance 0 Pain Relevance 0.82
In this study, we used laser-scanning microscopy to demonstrate that estrogen treatment induces the translocation of mu-OR immunoreactivity (mu-ORi) from the membrane to an internal location in steroid-sensitive cell groups of the limbic system and hypothalamus.
Localization (translocation) of mu-OR immunoreactivity in internal associated with limbic system
13) Confidence 0.56 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570823 Disease Relevance 0 Pain Relevance 0.47
These data imply that estrogen treatment stimulates the release of endogenous opioids that activate mu-OR in the limbic system and hypothalamus providing a "neurochemical signature" of steroid activation of these circuits.
Localization (release) of mu-OR in hypothalamus associated with endogenous opioid and limbic system
14) Confidence 0.56 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570823 Disease Relevance 0 Pain Relevance 0.42
In this study, we used laser-scanning microscopy to demonstrate that estrogen treatment induces the translocation of mu-OR immunoreactivity (mu-ORi) from the membrane to an internal location in steroid-sensitive cell groups of the limbic system and hypothalamus.
Localization (translocation) of mu-ORi in internal associated with limbic system
15) Confidence 0.56 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570823 Disease Relevance 0 Pain Relevance 0.47
This suggests that changes in MOP receptor levels are not related to systemically released mediators.
Localization (released) of MOP receptor
16) Confidence 0.54 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593084 Disease Relevance 0.60 Pain Relevance 0.88
In addition, we performed the Re-ChIP assay to verify the Sp3 and NRSF are specifically co-localized on MOR DNA (Figure 7C).
Localization (localized) of MOR associated with mu opioid receptor
17) Confidence 0.52 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.33
Two of the QTL reported, Morph1 and Morph4 co-localise with the strong candidate genes, Oprk and Oprm, which encode kappa (?
Localization (localise) of Oprm
18) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.19 Pain Relevance 0.78
translocates to the MOR, activated G?
Localization (translocates) of MOR associated with opioid receptor
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.39
Importantly, Akt proteins recruited to MOR lacked phosphorylation on both the Thr308 and Ser473 residues.
Neg (lacked) Localization (recruited) of MOR associated with opioid receptor
20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.07 Pain Relevance 0.81

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