INT87338

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.75
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
AsPC-1 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 14 96.48 Very High Very High Very High
cINOD 4 90.16 High High
endometriosis 2 50.00 Quite Low
palliative 6 27.64 Quite Low
Dismenorea 2 10.00 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Tendonitis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 205 99.84 Very High Very High Very High
Pancreatic Cancer 295 99.80 Very High Very High Very High
Apoptosis 246 95.12 Very High Very High Very High
Metastasis 67 93.88 High High
Adhesions 85 91.76 High High
Cicatrix 2 85.76 High High
Colon Cancer 11 76.20 Quite High
Malignant Neoplastic Disease 12 72.60 Quite High
Hyperplasia 5 52.08 Quite High
Endometriosis (extended) 2 51.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Those results suggest that FAK may play a role in the pathogenesis of endometriosis and be regulated by steroid hormones.


Regulation (regulated) of FAK
1) Confidence 0.62 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.05 Pain Relevance 0
These data strongly suggest that chemopreventive drugs can regulate FAK activity.
Regulation (regulate) of FAK
2) Confidence 0.62 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 0.53 Pain Relevance 0.16
Besides the regulation of FAK expression, another well-understood mode of FAK regulation in cancer cells is phosphorylation, particularly tyrosine phosphorylation [18].
Regulation (regulation) of FAK associated with cancer
3) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.40 Pain Relevance 0
To determine whether LN-induced Akt activation in AsPC-1 cells was dependent on FAK, pool cells transfected with FAK RNAi2, pcDNA3.1-FRNK or their respective vector control were obtained.
Regulation (control) of FAK in AsPC-1
4) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.21 Pain Relevance 0
The levels of total FAK, Akt and ERK protein were not significantly affected.
Neg (not) Regulation (affected) of FAK
5) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.54 Pain Relevance 0
To determine whether LN-induced Akt activation in AsPC-1 cells was dependent on FAK, pool cells transfected with FAK RNAi2, pcDNA3.1-FRNK or their respective vector control were obtained.
Regulation (control) of pcDNA3.1-FRNK in AsPC-1
6) Confidence 0.37 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.21 Pain Relevance 0
Our results indicate that FAK is a potential target for pancreatic cancer treatment.
Regulation (target) of FAK associated with pancreatic cancer
7) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.52 Pain Relevance 0
In recent studies, researchers have begun to hypothesize that FAK is a key determinant of chemoresistance since the modulation of FAK function through antisense oligonucleotides or RNAi influences the sensitivity of different kinds of tumor cells to various chemotherapeutic agents [15,16,34].
Regulation (modulation) of FAK associated with cancer
8) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.72 Pain Relevance 0
3 integrins and an up regulation of phospho-paxillin and phospho-FAK in cell lysates compared to solid surfaces.
Regulation (regulation) of FAK
9) Confidence 0.14 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.09 Pain Relevance 0
Genistein has been shown to exert inhibitory effects on targets that are involved in almost every step of the metastatic cascade, including FAK, integrins, TGF-?
Regulation (targets) of FAK
10) Confidence 0.11 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.49 Pain Relevance 0.05

General Comments

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