INT87340

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.96
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (BCAR1) cytosol (BCAR1) signal transduction (BCAR1)
cell adhesion (BCAR1) plasma membrane (BCAR1) cell division (BCAR1)
Anatomy Link Frequency
spinal 1
external 1
BCAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
GABAergic 2 98.76 Very High Very High Very High
Neuropathic pain 8 97.20 Very High Very High Very High
gABA 6 94.88 High High
Dorsal horn neuron 2 89.32 High High
cINOD 4 85.76 High High
allodynia 4 85.52 High High
Spinal cord 2 84.80 Quite High
Inflammation 1 83.76 Quite High
Versed 6 79.36 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 84 100.00 Very High Very High Very High
Chromosome Aberrations 12 100.00 Very High Very High Very High
Hypertension 45 99.92 Very High Very High Very High
Fever 10 99.44 Very High Very High Very High
Adhesions 2 98.92 Very High Very High Very High
Neuropathic Pain 19 97.92 Very High Very High Very High
Cleft Palate 14 95.44 Very High Very High Very High
Colon Cancer 4 92.28 High High
Cryptorchidism 4 86.36 High High
Respiratory Disease 2 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of CAs induced by human teratogenic drugs is about 6 per 1,000 on the basis of Table 1 and 2 (Table 3).
Negative_regulation (number) of CAs associated with congenital anomalies
1) Confidence 0.38 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.98 Pain Relevance 0.05
The total number of CAs which may be associated with hyperthermia is 8.7 per 1,000 and these CAs can be prevented by effective antifever therapy, including drugs (Table 3).
Negative_regulation (prevented) of CAs associated with congenital anomalies and fever
2) Confidence 0.37 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.41 Pain Relevance 0
Thus, we also hypothesized that spinal inhibition of CAs might enhance the anti-allodynic effects of spinally administered benzodiazepines.
Negative_regulation (inhibition) of CAs in spinal
3) Confidence 0.33 Published 2010 Journal Pain Section Abstract Doc Link 20007010 Disease Relevance 0.79 Pain Relevance 0.84
Carbonic anhydrases (CA) facilitate intracellular HCO(3)(-) generation and hence, we hypothesized that inhibition of CAs would enhance the efficacy of GABAergic inhibition in the context of neuropathic pain.
Negative_regulation (inhibition) of CAs associated with gabaergic and neuropathic pain
4) Confidence 0.33 Published 2010 Journal Pain Section Abstract Doc Link 20007010 Disease Relevance 0.64 Pain Relevance 0.76
These drugs also reduced the tyrosine phosphorylation of FAK and an associated factor, p130Cas.
Negative_regulation (reduced) of p130Cas
5) Confidence 0.32 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 0.87 Pain Relevance 0.27
CAs antagonists and ARBs, including amlodipine and valsartan, are easy to use and can be administered to nearly all hypertensive patients, which represents a major advantage in everyday practice.
Negative_regulation (administered) of CAs associated with antagonist and hypertension
6) Confidence 0.26 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 0.84 Pain Relevance 0.24
Area under the curve of cortisol at castration day was reduced (P < 0.05) in CAS calves compared with INT calves (18 vs. 33 +/- 5.2 nmol/L per hour, respectively).
Negative_regulation (reduced) of CAS
7) Confidence 0.06 Published 2010 Journal J. Anim. Sci. Section Abstract Doc Link 20418456 Disease Relevance 0.33 Pain Relevance 0.47
CAs were found to be significantly different in the three patients groups compared with the external control (p < 0.01; Table 1).
Negative_regulation (different) of CAs in external associated with chromosome aberrations
8) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.10 Pain Relevance 0

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