INT87341

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2009
Negated 4
Speculated 5
Reported most in Body
Documents 2
Total Number 13
Disease Relevance 8.34
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
AsPC-1 8
endometrium 6
colon 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 6 100.00 Very High Very High Very High
endometriosis 6 98.92 Very High Very High Very High
cINOD 4 98.26 Very High Very High Very High
palliative 9 52.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 71 100.00 Very High Very High Very High
Apoptosis 336 99.80 Very High Very High Very High
Endometriosis (extended) 6 98.92 Very High Very High Very High
Pancreatic Cancer 432 98.88 Very High Very High Very High
Death 9 98.68 Very High Very High Very High
Colon Cancer 4 98.48 Very High Very High Very High
Metastasis 36 97.96 Very High Very High Very High
Cancer 154 97.92 Very High Very High Very High
Malignant Neoplastic Disease 18 97.08 Very High Very High Very High
Breast Cancer 9 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis.
Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (expression) of FAK in endometrium associated with endometriosis and adhesions
1) Confidence 0.62 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17543958 Disease Relevance 0.35 Pain Relevance 0.09
Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis.
Regulation (Alteration) of Gene_expression (expression) of focal adhesion kinase in endometrium associated with endometriosis, dismenorea and adhesions
2) Confidence 0.62 Published 2008 Journal Fertil. Steril. Section Title Doc Link 17543958 Disease Relevance 0.20 Pain Relevance 0.30
Therefore, we asked whether the NSAID, sulindac sulfide, and the phenolic antioxidant, caffeic acid phenethyl ester (CAPE), affected FAK expression or tyrosine phosphorylation in human colon carcinoma cells.
Spec (whether) Regulation (affected) of Gene_expression (expression) of FAK in colon associated with colon cancer and cinod
3) Confidence 0.62 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 1.02 Pain Relevance 0.24
Besides the regulation of FAK expression, another well-understood mode of FAK regulation in cancer cells is phosphorylation, particularly tyrosine phosphorylation [18].
Regulation (regulation) of Gene_expression (expression) of FAK associated with cancer
4) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.42 Pain Relevance 0
Moreover, the modulation of FAK expression and (or) phosphorylation influences the sensitivity of tumor cells to various chemotherapeutic agents, and combination of the selective FAK inhibitors with cytotoxic agents might be a very promising anti-cancer therapy [14-16].
Spec (might) Regulation (modulation) of Gene_expression (expression) of FAK associated with cancer
5) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.49 Pain Relevance 0.05
Effects of FAK RNAi and FRNK overexpression on LN-mediated Gem chemoresistance in AsPC-1 cells
Regulation (Effects) of Gene_expression (overexpression) of FAK RNAi in AsPC-1
6) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
OBJECTIVE: To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis.
Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (expression) of focal adhesion kinase in endometrium associated with endometriosis and adhesions
7) Confidence 0.45 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17543958 Disease Relevance 0.35 Pain Relevance 0.09
However, FRNK overexpression did not significantly affect Gem-induced apoptosis in AsPC-1 cells that had low level of pFAK (pY397).
Neg (not) Regulation (affect) of Gene_expression (overexpression) of FRNK in AsPC-1 associated with apoptosis
8) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.70 Pain Relevance 0
Effects of FAK RNAi and FRNK overexpression on LN-mediated Gem chemoresistance in AsPC-1 cells
Regulation (Effects) of Gene_expression (overexpression) of FRNK in AsPC-1
9) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
However, FRNK overexpression did not significantly affect the apoptosis of Panc-1 cells in the absence of Gem.
Neg (not) Regulation (affect) of Gene_expression (overexpression) of FRNK associated with apoptosis
10) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.81 Pain Relevance 0
However, FRNK overexpression did not significantly affect Gem-induced apoptosis in AsPC-1 cells on plastic (Fig. 10B).
Neg (not) Regulation (affect) of Gene_expression (overexpression) of FRNK in AsPC-1 associated with apoptosis
11) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.50 Pain Relevance 0
We further determined the effects of FRNK overexpression on Gem-induced apoptosis in Panc-1 cells.
Spec (determined) Regulation (effects) of Gene_expression (overexpression) of FRNK associated with apoptosis
12) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.64 Pain Relevance 0
Compared with nontransfection and vector-transfection controls, transient transfection of RNAi plasmids (FAK RNAi1 and FAK RNAi2) resulted in downregulation of FAK protein levels and subsequent reduction of pFAK (pY397) levels (Fig. 3A), whereas transfection of pcDNA3.1-FRNK plasmid decreased pFAK levels without changing total FAK expression (Fig. 3B).
Neg (without) Regulation (changing) of Gene_expression (expression) of FAK
13) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.07 Pain Relevance 0

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