INT87342

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 5.70
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
MCF7 2
colon 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 99.82 Very High Very High Very High
cINOD 4 98.26 Very High Very High Very High
MU agonist 1 68.52 Quite High
opioid receptor 1 66.68 Quite High
opiate 1 62.88 Quite High
palliative 6 5.00 Very Low Very Low Very Low
Mechanotransduction 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 5 99.60 Very High Very High Very High
Pancreatic Cancer 288 98.92 Very High Very High Very High
Cancer 103 98.04 Very High Very High Very High
Malignant Neoplastic Disease 20 97.06 Very High Very High Very High
Apoptosis 226 94.96 High High
Adhesions 92 91.56 High High
Hyperplasia 1 78.92 Quite High
Lung Cancer 6 73.40 Quite High
INFLAMMATION 1 72.36 Quite High
Breast Cancer 6 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that induced FAK phosphorylation is involved in LN-mediated chemoresistance to Gem and further confirm FAK as a promising therapeutic target in pancreatic cancer.
Regulation (involved) of Phosphorylation (phosphorylation) of FAK associated with pancreatic cancer
1) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.49 Pain Relevance 0
Therefore, in our study PF-228 was further applied to confirm the role of FAK phosphorylation in the chemoresistance of pancreatic cancer cells.
Regulation (role) of Phosphorylation (phosphorylation) of FAK associated with pancreatic cancer
2) Confidence 0.59 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.39 Pain Relevance 0
In addition, survivin exression was also regulated by FAK phosphorylation.
Regulation (regulated) of Phosphorylation (phosphorylation) of FAK
3) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.93 Pain Relevance 0
Pretreatment of MCF7 cells with the specific PI-3 kinase inhibitor wortmannin abolished both the activation of Rac1 and actin reorganization, while the opioid-induced phosphorylation of FAK and vinculin remained unaffected.
Neg (unaffected) Regulation (unaffected) of Phosphorylation (phosphorylation) of FAK in MCF7 associated with malignant neoplastic disease and opioid
4) Confidence 0.41 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.66 Pain Relevance 0.80
Therefore, we asked whether the NSAID, sulindac sulfide, and the phenolic antioxidant, caffeic acid phenethyl ester (CAPE), affected FAK expression or tyrosine phosphorylation in human colon carcinoma cells.
Spec (whether) Regulation (affected) of Phosphorylation (phosphorylation) of FAK in colon associated with colon cancer and cinod
5) Confidence 0.27 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 1.02 Pain Relevance 0.24
It further confirms the role of constitutive FAK phosphorylation in the intrinsic chemoresistance to Gem in pancreatic cancer cells and indicates development of selective FAK phosphorylation inhibitors may be a promising way to enhance chemosensitivity in pancreatic cancer.
Regulation (role) of Phosphorylation (phosphorylation) of FAK associated with pancreatic cancer
6) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.88 Pain Relevance 0
In this study, we aimed to determine the roles of FAK phosphorylation in the intrinsic chemoresistance of pancreatic cancer cell lines.


Spec (determine) Regulation (roles) of Phosphorylation (phosphorylation) of FAK associated with pancreatic cancer
7) Confidence 0.26 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.58 Pain Relevance 0
Therefore, PF-228 was used in our study to confirm the role of FAK phosphorylation in the chemoresistance of pancreatic cancer cells.
Regulation (role) of Phosphorylation (phosphorylation) of FAK associated with pancreatic cancer
8) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.52 Pain Relevance 0
Interestingly, we could detect no change in FAK-Y397 phosphorylation during acute in vitro stretch of human term myometrial samples (Fig. 5A, top).
Neg (no) Regulation (change) of Phosphorylation (phosphorylation) of FAK-Y397
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.22 Pain Relevance 0

General Comments

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