INT87344

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 9
Reported most in Body
Documents 90
Total Number 101
Disease Relevance 59.03
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
AsPC-1 18
endometrium 3
colon 2
platelet 2
BxPC-3 2
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 16 99.72 Very High Very High Very High
endometriosis 16 98.48 Very High Very High Very High
cINOD 6 98.08 Very High Very High Very High
Inflammation 27 90.32 High High
palliative 84 59.72 Quite High
aspirin 3 50.00 Quite Low
metalloproteinase 42 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2859 100.00 Very High Very High Very High
Adhesions 696 100.00 Very High Very High Very High
Glioma 1 99.86 Very High Very High Very High
Pancreatic Cancer 3498 99.84 Very High Very High Very High
Metastasis 834 99.66 Very High Very High Very High
Skin Cancer 272 99.48 Very High Very High Very High
Breast Cancer 174 99.46 Very High Very High Very High
Apoptosis 2702 99.36 Very High Very High Very High
Colon Cancer 26 98.48 Very High Very High Very High
Endometriosis (extended) 16 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a positive correlation between FAK expression in secretory endometrial tissues and disease stage and pelvic pain in women with endometriosis.
Gene_expression (expression) of FAK
1) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.14 Pain Relevance 0
CONCLUSION(S): The study showed a significant increase of FAK expression in the secretory endometrial tissues of women with endometriosis, a relationship between FAK expression and disease stage, pelvic pain, and serum steroid hormones.
Gene_expression (expression) of FAK
2) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.12 Pain Relevance 0
Furthermore, the endometrial FAK protein expression varied with the serum E(2) at proliferative phase and with the ratio of E(2) to P at secretory phase.
Gene_expression (expression) of FAK
3) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.13 Pain Relevance 0
CONCLUSION(S): The study showed a significant increase of FAK expression in the secretory endometrial tissues of women with endometriosis, a relationship between FAK expression and disease stage, pelvic pain, and serum steroid hormones.
Gene_expression (expression) of FAK
4) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.11 Pain Relevance 0
RESULT(S): At secretory phase, the average level of endometrial FAK expression of women with endometriosis was significantly higher than that of controls, but no significant difference was found between the two groups at proliferative phase.
Gene_expression (expression) of FAK
5) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.16 Pain Relevance 0
Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis.
Gene_expression (expression) of focal adhesion kinase in endometrium associated with endometriosis, dismenorea and adhesions
6) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Title Doc Link 17543958 Disease Relevance 0.20 Pain Relevance 0.30
OBJECTIVE: To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis.
Spec (whether) Gene_expression (expression) of FAK in endometrium associated with endometriosis and adhesions
7) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17543958 Disease Relevance 0.35 Pain Relevance 0.09
OBJECTIVE: To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis.
Spec (whether) Gene_expression (expression) of focal adhesion kinase in endometrium associated with endometriosis and adhesions
8) Confidence 0.78 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17543958 Disease Relevance 0.35 Pain Relevance 0.09
Therefore, we asked whether the NSAID, sulindac sulfide, and the phenolic antioxidant, caffeic acid phenethyl ester (CAPE), affected FAK expression or tyrosine phosphorylation in human colon carcinoma cells.
Gene_expression (expression) of FAK in colon associated with colon cancer and cinod
9) Confidence 0.78 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 1.02 Pain Relevance 0.24
Cytoplasmic FAK expression (FAKc) in cancer and metastases was mostly weak to moderate, and considerable intra-tumoral heterogeneity was observed.
Gene_expression (expression) of FAK associated with cancer and metastasis
10) Confidence 0.75 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.03 Pain Relevance 0
We further determined the effects of FRNK overexpression on Gem-induced apoptosis in Panc-1 cells.
Gene_expression (overexpression) of FRNK associated with apoptosis
11) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.64 Pain Relevance 0
The effect of LN on Akt activation was almost completely blocked by inhibition of FAK phosphorylation through either FAK RNAi or FRNK overexpression (Fig. 7A-B).
Gene_expression (overexpression) of FAK RNAi
12) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.21 Pain Relevance 0
The effect of LN on Akt activation was almost completely blocked by inhibition of FAK phosphorylation through either FAK RNAi or FRNK overexpression (Fig. 7A-B).
Gene_expression (overexpression) of FRNK
13) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.16 Pain Relevance 0
Similar results were obtained in Panc-1 cells stably transfected with the FAK RNAi2 plasmid (data not shown).
Gene_expression (transfected) of FAK
14) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.50 Pain Relevance 0
The C-terminal non-catalytic domain of FAK termed FRNK functions as a competitive inhibitor of FAK and ectopic expression of FRNK specifically inhibits FAK autophosphorylation at Tyr397 and thus attenuates its activity [19,20].
Gene_expression (expression) of FRNK
15) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.59 Pain Relevance 0
It has also been reported previously that FAK protein expression might not be a prognostic marker for pancreatic cancer patients [17].
Gene_expression (expression) of FAK associated with pancreatic cancer
16) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.61 Pain Relevance 0
Thus, we investigated whether inhibition of FAK activity by FRNK overexpression might modulate these proteins and thereby regulate apoptosis in Panc-1 cells.
Gene_expression (overexpression) of FRNK associated with apoptosis
17) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.71 Pain Relevance 0
In this study, we first investigated the correlation between the level of constitutive FAK expression and phosphorylation and the extent of chemoresistance in four pancreatic cancer cell lines.
Gene_expression (expression) of FAK associated with pancreatic cancer
18) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.27 Pain Relevance 0
High FAK protein expression is also present in pancreatic cancer, but not significantly related to clinicopathological factors such as tumor histological grade, lymph node metastasis, distant metastasis, histological stage, and overall survival in pancreatic cancer patients [17].
Gene_expression (expression) of FAK in lymph node associated with cancer, pancreatic cancer and metastasis
19) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.48 Pain Relevance 0
We demonstrated herein that specific RNAi against FAK reduced FAK expression, decreased FAK phosphorylation and thus suppressed the intrinsic chemoresistance to Gem in Panc-1 cells, which had a high level of pFAK (pY397).
Gene_expression (expression) of FAK
20) Confidence 0.74 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.52 Pain Relevance 0

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