INT87346

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.03
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
plaque 1
epithelial cells 1
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 16 98.34 Very High Very High Very High
metalloproteinase 28 97.36 Very High Very High Very High
cINOD 4 89.72 High High
agonist 5 84.32 Quite High
Opioid 3 55.36 Quite High
antagonist 1 54.80 Quite High
opioid receptor 2 54.24 Quite High
Mechanotransduction 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 129 99.28 Very High Very High Very High
Malignant Neoplastic Disease 1 99.12 Very High Very High Very High
Apoptosis 46 96.76 Very High Very High Very High
Hyperplasia 9 95.72 Very High Very High Very High
Colon Cancer 19 91.52 High High
INFLAMMATION 1 89.16 High High
Cancer 207 88.72 High High
Reprotox - General 1 116 79.32 Quite High
Disease 7 79.28 Quite High
Metastasis 86 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus far, FAK has not been identified as a target for the inhibitory action of any chemopreventive drug in vivo or in vitro.
FAK Binding (target) of
1) Confidence 0.37 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741720 Disease Relevance 1.07 Pain Relevance 0.26
Consistently, activated kappa-opioid receptor induced Src stimulation and FAK autophosphorylation and promoted the formation of Src-FAK complex.
Src-FAK Binding (complex) of associated with kappa opioid receptor
2) Confidence 0.33 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.17 Pain Relevance 0.40
Consistently, activated kappa-opioid receptor induced Src stimulation and FAK autophosphorylation and promoted the formation of Src-FAK complex.
Src-FAK Binding (complex) of associated with kappa opioid receptor
3) Confidence 0.33 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.17 Pain Relevance 0.40
We have recently identified a specific signaling pathway that regulates actin reorganization in malignant human breast and prostate epithelial cells associated with FAK, PI-3K and Rac1 activation.
FAK Binding (associated) of in epithelial cells associated with malignant neoplastic disease
4) Confidence 0.29 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.23 Pain Relevance 0.08
Thus, since phosphorylation of the adhesion plaque protein FAK at residue 925 increases in these samples with stretch, we probed for the association of phospho-FAK-Y925 with ERK and, as is shown in Fig. 8D, this association also increased with stretch.


FAK Binding (association) of in plaque associated with adhesions
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.48 Pain Relevance 0
Genistein has been shown to exert inhibitory effects on targets that are involved in almost every step of the metastatic cascade, including FAK, integrins, TGF-?
FAK Binding (integrins) of
6) Confidence 0.09 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.52 Pain Relevance 0.05
FAK then forms a complex with ?
FAK Binding (complex) of
7) Confidence 0.09 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 1.38 Pain Relevance 0

General Comments

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