INT87357

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.97
Pain Relevance 0.22

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nucleus (MSX2) transcription factor binding (MSX2) cytoplasm (MSX2)
Anatomy Link Frequency
Mouse 2
MSX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 77.84 Quite High
Disease Link Frequency Relevance Heat
Craniosynostosis 6 100.00 Very High Very High Very High
Vascular Malformations 3 80.08 Quite High
Headache 3 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings contrast with the only described MSX2 homeodomain mutation (P148H), associated with craniosynostosis, that binds with enhanced affinity to the same target.
MSX2 Binding (binds) of associated with craniosynostosis
1) Confidence 0.48 Published 2000 Journal Nat. Genet. Section Abstract Doc Link 10742103 Disease Relevance 0.33 Pain Relevance 0.07
Mouse Msx2 protein with either of the homeodomain mutations exhibited more than 85% reduction in binding to an optimal Msx2 DNA-binding site.
Msx2 Binding (binding) of in Mouse
2) Confidence 0.35 Published 2000 Journal Nat. Genet. Section Abstract Doc Link 10742103 Disease Relevance 0.32 Pain Relevance 0.08
Mouse Msx2 protein with either of the homeodomain mutations exhibited more than 85% reduction in binding to an optimal Msx2 DNA-binding site.
Msx2 Binding (site) of in Mouse
3) Confidence 0.35 Published 2000 Journal Nat. Genet. Section Abstract Doc Link 10742103 Disease Relevance 0.32 Pain Relevance 0.07

General Comments

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