INT87374

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.91
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
medulla 3
neurons 2
interneurons 1
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 15 99.48 Very High Very High Very High
Somatostatin 4 98.96 Very High Very High Very High
projection neuron 3 98.50 Very High Very High Very High
substance P 7 97.68 Very High Very High Very High
cytokine 6 93.40 High High
Pain 6 88.80 High High
Enkephalin 4 84.88 Quite High
tetrodotoxin 2 78.24 Quite High
nMDA receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 5 99.78 Very High Very High Very High
Toxocariasis 3 99.58 Very High Very High Very High
Neuroblastoma 6 98.68 Very High Very High Very High
Tendinopathy 18 98.40 Very High Very High Very High
Sudden Infant Death Syndrome 12 97.72 Very High Very High Very High
Nicotine Addiction 3 96.16 Very High Very High Very High
Hyperplasia 2 75.20 Quite High
Alzheimer's Dementia 4 63.52 Quite High
Pain 4 48.20 Quite Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic prenatal exposure to carbon monoxide results in a reduction in tyrosine hydroxylase-immunoreactivity and an increase in choline acetyltransferase-immunoreactivity in the fetal medulla: implications for Sudden Infant Death Syndrome.
Positive_regulation (increase) of choline acetyltransferase in medulla associated with medulla and sudden infant death syndrome
1) Confidence 0.67 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 10744060 Disease Relevance 0.44 Pain Relevance 0.23
Using immunohistochemistry and quantitative image analysis, examination of the medulla of CO-exposed fetuses revealed a significant decrease in tyrosine hydroxylase-immunoreactivity (TH-IR) in the nucleus tractus solitarius, dorsal motor nucleus of the vagus (DMV), area postrema, intermediate reticular nucleus, and the ventrolateral medulla (VLM), and a significant increase in choline acetyltransferase-immunoreactivity (ChAT-IR) in the DMV and hypoglossal nucleus compared with controls.
Positive_regulation (increase) of choline acetyltransferase in medulla associated with medulla and toxocariasis
2) Confidence 0.67 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10744060 Disease Relevance 0.38 Pain Relevance 0.33
Using immunohistochemistry and quantitative image analysis, examination of the medulla of CO-exposed fetuses revealed a significant decrease in tyrosine hydroxylase-immunoreactivity (TH-IR) in the nucleus tractus solitarius, dorsal motor nucleus of the vagus (DMV), area postrema, intermediate reticular nucleus, and the ventrolateral medulla (VLM), and a significant increase in choline acetyltransferase-immunoreactivity (ChAT-IR) in the DMV and hypoglossal nucleus compared with controls.
Positive_regulation (increase) of ChAT in medulla associated with medulla and toxocariasis
3) Confidence 0.49 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10744060 Disease Relevance 0.38 Pain Relevance 0.33
The presumed local production of acetylcholine (ACh), as evidenced by immunoreactivity for ChAT and VAChT and the detection of ChAT mRNA, appears to evolve in response to tendinosis.
Positive_regulation (immunoreactivity) of ChAT associated with tendinopathy
4) Confidence 0.48 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.80 Pain Relevance 0.14
The presumed local production of acetylcholine (ACh), as evidenced by immunoreactivity for ChAT and VAChT and the detection of ChAT mRNA, appears to evolve in response to tendinosis.
Positive_regulation (detection) of ChAT associated with tendinopathy
5) Confidence 0.48 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.74 Pain Relevance 0.09
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of choline acetyltransferase in neurons associated with generalized anxiety disorder
6) Confidence 0.44 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.46 Pain Relevance 0.17
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of ChAT in neurons associated with generalized anxiety disorder
7) Confidence 0.44 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
The neuronal populations were identified with digoxigenin-tagged complementary RNA probes for preproenkephalin (ENK) and substance P (SP) targeted to striatal projection neurons, and somatostatin (SOM), glutamic acid decarboxylase 67 kD (GAD(67)), and choline acetyltransferase (ChAT) targeted to striatal interneurons.
Positive_regulation (targeted) of choline acetyltransferase in interneurons associated with generalized anxiety disorder, somatostatin, projection neuron and substance p
8) Confidence 0.40 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10742712 Disease Relevance 0.24 Pain Relevance 0.49

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