INT87393

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 11.00
Pain Relevance 10.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
brain 2
neurons 2
T cells 2
macrophage 1
sensory neurons 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 780 100.00 Very High Very High Very High
Neuritis 10 99.96 Very High Very High Very High
opioid receptor 4 99.74 Very High Very High Very High
dorsal root ganglion 6 99.60 Very High Very High Very High
Multiple sclerosis 5 99.58 Very High Very High Very High
cytokine 42 98.72 Very High Very High Very High
Central nervous system 24 98.32 Very High Very High Very High
Inflammation 39 98.08 Very High Very High Very High
Demyelination 332 98.00 Very High Very High Very High
Lasting pain 56 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Optic Neuritis 10 99.96 Very High Very High Very High
Ganglion Cysts 13 99.60 Very High Very High Very High
Demyelinating Disease 344 99.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 99.24 Very High Very High Very High
Neurological Disease 16 98.80 Very High Very High Very High
Nervous System Injury 202 98.20 Very High Very High Very High
INFLAMMATION 62 98.08 Very High Very High Very High
Pain 194 97.88 Very High Very High Very High
Infection 4 96.94 Very High Very High Very High
Immunodeficiency 1 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis confirmed the expression of CXCR4, CX3CR1, CCR4, and CCR5 mRNAs in DRG neurons.
Gene_expression (expression) of CCR5 in neurons associated with dorsal root ganglion
1) Confidence 0.65 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438578 Disease Relevance 1.35 Pain Relevance 1.39
Opiates may also promote immunodeficiency virus infection by decreasing the secretion of alpha and beta chemokines (important inhibitory cytokines for the expression of HIV) and at the same time increasing the expression of chemoreceptors CCR5 and CCR3, coreceptors for the virus.
Gene_expression (expression) of CCR5 associated with chemokine, acquired immune deficiency syndrome or hiv infection, opiate, infection, immunodeficiency and cytokine
2) Confidence 0.65 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356431 Disease Relevance 0.52 Pain Relevance 1.21
Like CCR5, RANTES was expressed in small, medium and large sensory neurons (Fig 7B, C).
Gene_expression (expressed) of CCR5 in sensory neurons
3) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.71 Pain Relevance 0.06
CCR5 is expressed in both neuronal and glial cells in the rat brain.
Gene_expression (expressed) of CCR5 in brain
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.78 Pain Relevance 0.39
Since the rat CCR2 receptor shares 85% homology at the amino acid level with CCR5, AZ889 was further profiled on CHO cells stably expressing rat CCR5 and stimulated with the CCR5 ligand macrophage inflammatory protein 1alpha (MIP-1?).
Gene_expression (expressing) of CCR5 in macrophage associated with inflammation
5) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.16 Pain Relevance 0.16
For the CXCR3 and CCR5 probes, we used the CD1 mouse brain cDNA.
Gene_expression (probes) of CCR5 in brain
6) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0 Pain Relevance 0.04
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Gene_expression (function) of CCR5 receptor in neurons associated with demyelination
7) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.57 Pain Relevance 0.81
Lumbar DRGs derived from injured animals on POD35 showed no CCR5 mRNA staining (data not shown).


Neg (no) Gene_expression (staining) of CCR5 mRNA
8) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.65 Pain Relevance 0.42
This behavior was accompanied by a bilateral increase in the numbers of primary sensory neurons expressing the chemokine receptors CCR2, CCR5, and CXCR4 by POD14, with no change in the pattern of CXCR3 expression.
Gene_expression (expressing) of CCR5 in primary sensory neurons associated with chemokine
9) Confidence 0.48 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2228278 Disease Relevance 0.94 Pain Relevance 0.71
We used in situ hybridization to study the levels of RANTES expression, one known ligand for CCR5, in the DRG ipsilateral and contralateral to the nerve injury.
Gene_expression (expression) of CCR5 in nerve associated with nervous system injury
10) Confidence 0.48 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 0.03
Next we used in situ hybridization to examine the expression of the chemokine receptors CXCR3 and CCR5 in the DRG associated with the LPC-induced focal demyelination.
Spec (examine) Gene_expression (expression) of CCR5 associated with chemokine and demyelination
11) Confidence 0.48 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.52 Pain Relevance 0.35
Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls.
Gene_expression (expression) of CCR5 associated with chemokine
12) Confidence 0.38 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.52 Pain Relevance 0.45
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Gene_expression (expressing) of CCR5 in blood associated with multiple sclerosis, optic neuritis and neuritis
13) Confidence 0.38 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.55
Patients with optic neuritis (ON), a common first manifestation of MS, had elevated percentages of CXCR3 expressing T cells in blood compared with HC, and of CCR5 expressing T cells in CSF compared with OND patients.
Gene_expression (expressing) of CCR5 in T cells associated with neurological disease, optic neuritis and neuritis
14) Confidence 0.38 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.61 Pain Relevance 0.54
Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF.
Gene_expression (expressing) of CCR5 in T cells associated with neurological disease and inflammation
15) Confidence 0.33 Published 2002 Journal J. Neurol. Section Abstract Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.52
Both down-regulation of CCR5 and reduced expression of Mac-1 may diminish the potential of peripheral blood monocytes to leave blood vessels and invade target tissues.
Gene_expression (expression) of CCR5 in blood vessels
16) Confidence 0.19 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744623 Disease Relevance 0.51 Pain Relevance 0.46
We observed that curcumin inhibited Abeta1-40-induced expression of CCR5 but not of CCR2b in THP-1 cells.
Gene_expression (expression) of CCR5 in THP-1
17) Confidence 0.18 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.60 Pain Relevance 0.37
Previously, our laboratory reported that activation of the mu-opioid receptor induced the expression of CCL2, CCL5, and CXCL10, as well as CCR5 and CXCR4.
Gene_expression (expression) of CCR5 associated with opioid receptor
18) Confidence 0.13 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.63
In turn, the addition of TGF-beta1 was found to induce CCL5 and CXCR4 expression but not CCL2, CXCL10, or CCR5.
Gene_expression (expression) of CCR5
19) Confidence 0.13 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.87
Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
Gene_expression (expressing) of CCR5 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
20) Confidence 0.13 Published 2002 Journal J. Neurol. Section Title Doc Link 12111306 Disease Relevance 0.59 Pain Relevance 0.55

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