INT87394

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
blood vessels 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 29 100.00 Very High Very High Very High
lidocaine 9 94.54 High High
antagonist 9 93.68 High High
cINOD 5 85.20 High High
agonist 1 68.88 Quite High
aspirin 1 68.24 Quite High
Inflammation 17 50.00 Quite Low
ischemia 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 7 95.18 Very High Very High Very High
Sarcoma 1 87.12 High High
Cancer 6 85.72 High High
Herpes Simplex Virus 2 85.12 High High
Reperfusion Injury 5 75.00 Quite High
INFLAMMATION 19 67.12 Quite High
Malignant Neoplastic Disease 1 62.08 Quite High
Coronary Artery Disease 1 61.84 Quite High
Injury 9 5.00 Very Low Very Low Very Low
Vascular System Injuries 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In acute renal allograft rejection, the selective blockade of the CC chemokine receptors CCR1, CCR5 and CXCR3 led to reduced allograft damage [1, 4, 5].
Negative_regulation (blockade) of CCR5 associated with chemokine
1) Confidence 0.32 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.17 Pain Relevance 0.62
Lidocaine administration during ischaemia and reperfusion led to an improved recovery of LVDP during reperfusion (1.7 microg ml(-1), 54 (SEM 10) mm Hg; 17 microg ml(-1), 71 (9) mm Hg at 30 min of reperfusion; both significantly different from control (21 (4) mm Hg) (P<0.05)) and a reduced CKR (1.7 microg ml(-1), 79 (13) IU; 17 microg ml(-1), 52 (8) IU at 30 min of reperfusion; both significantly different from control (130 (8) IU (P<0.05)).
Negative_regulation (reduced) of CKR associated with cv unclassified under development and lidocaine
2) Confidence 0.30 Published 2001 Journal Br J Anaesth Section Abstract Doc Link 11573594 Disease Relevance 0.62 Pain Relevance 0.67
Both down-regulation of CCR5 and reduced expression of Mac-1 may diminish the potential of peripheral blood monocytes to leave blood vessels and invade target tissues.
Negative_regulation (down-regulation) of CCR5 in blood vessels
3) Confidence 0.16 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744623 Disease Relevance 0.51 Pain Relevance 0.46

General Comments

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