INT87395

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Context Info
Confidence 0.29
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.50
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
monocyte 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 241 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
Analgesic 2 99.12 Very High Very High Very High
Demyelination 94 98.88 Very High Very High Very High
Endogenous opioid 2 98.32 Very High Very High Very High
agonist 3 97.84 Very High Very High Very High
Hyperalgesia 28 95.08 Very High Very High Very High
ischemia 3 94.96 High High
Central nervous system 1 94.92 High High
Sciatic nerve 30 91.20 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 96 98.88 Very High Very High Very High
Cancer 8 98.78 Very High Very High Very High
Hyperalgesia 42 95.08 Very High Very High Very High
Nervous System Injury 56 95.04 Very High Very High Very High
Cv Unclassified Under Development 3 94.96 High High
Injury 37 92.80 High High
Malignant Neoplastic Disease 1 90.36 High High
INFLAMMATION 34 85.44 High High
Pain 52 82.20 Quite High
Cv General 4 Under Development 1 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next we used in situ hybridization to examine the expression of the chemokine receptors CXCR3 and CCR5 in the DRG associated with the LPC-induced focal demyelination.
CCR5 Binding (associated) of associated with chemokine and demyelination
1) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.52 Pain Relevance 0.35
Chemokine interactions with CCR5 may also depress the analgesic action of endogenous opioids and/or sensitize TRPV1 [10,53,54] thereby generally promoting hyperalgesia.
CCR5 Binding (interactions) of associated with chemokine, hyperalgesia, analgesic and endogenous opioid
2) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.57 Pain Relevance 0.86
Here, vMIP-II prevented CCR1 and CCR5 receptor internalization, which mediate arrest and transmigration of these cells [16].
CCR5 receptor Binding (internalization) of
3) Confidence 0.28 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.41 Pain Relevance 0.09
Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1.
CCR5 Binding (interfering) of in monocyte associated with cancer
4) Confidence 0.10 Published 2000 Journal FASEB J. Section Title Doc Link 10744623 Disease Relevance 0.58 Pain Relevance 0.32
This involved abrogation of Egr-1 DNA binding in the promoter of CCR5 by curcumin as determined by: (i) electrophoretic mobility shift assay, (ii) transfection studies with truncated CCR5 gene promoter constructs, and (iii) chromatin immunoprecipitation analysis.
CCR5 Spec (determined) Binding (binding) of
5) Confidence 0.08 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.42 Pain Relevance 0.33
Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor.
chemokine CCR5 receptor Binding (Heterodimerization) of associated with chemokine and opioid receptor
6) Confidence 0.00 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 14729105 Disease Relevance 0 Pain Relevance 0.66

General Comments

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