INT874

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2009
Negated 9
Speculated 4
Reported most in Abstract
Documents 244
Total Number 248
Disease Relevance 27.17
Pain Relevance 97.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 64
pituitary 23
somatotrophs 6
IVT 4
hypothalamus 3
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 495 100.00 Very High Very High Very High
Clonidine 431 100.00 Very High Very High Very High
Somatostatin 429 100.00 Very High Very High Very High
Morphine 174 100.00 Very High Very High Very High
anesthesia 76 100.00 Very High Very High Very High
Delta opioid receptors 2 99.92 Very High Very High Very High
Serotonin 112 99.84 Very High Very High Very High
Intracerebroventricular 29 99.84 Very High Very High Very High
narcan 78 99.82 Very High Very High Very High
opiate 63 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 990 99.96 Very High Very High Very High
Diabetes Mellitus 66 99.84 Very High Very High Very High
Hypoglycemia 16 99.84 Very High Very High Very High
Breast Cancer 9 99.84 Very High Very High Very High
Rheumatoid Arthritis 306 99.74 Very High Very High Very High
Arthritis 68 99.68 Very High Very High Very High
Eating Disorder 72 99.64 Very High Very High Very High
Body Weight 80 99.50 Very High Very High Very High
Starvation 189 99.44 Very High Very High Very High
INFLAMMATION 658 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine exposure of male rats caused a 12-fold increase in basal GH levels and a modest rise in GH pulse frequency.
Positive_regulation (increase) of GH associated with morphine
1) Confidence 0.70 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.69
These two changes resulted in a 3-fold increase in both mean GH concentration and total GH secretion over 6 h.
Positive_regulation (increase) of GH
2) Confidence 0.70 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.69
Yohimbine did not affect serum GH levels in separated two-day-old pups (i.e. basal levels of the hormone), but prevented the nursing-induced increase in serum GH concentration.
Positive_regulation (increase) of GH
3) Confidence 0.69 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.50
In two-day-old pups, clonidine had no effect on basal GH levels but, like yohimbine, prevented the increase in serum GH normally associated with nursing.
Positive_regulation (increase) of GH associated with clonidine
4) Confidence 0.69 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.51
In eight-day-old pups, yohimbine prevented the nursing-induced increase in serum GH and decreased GH levels below the saline-injected, separated control.
Positive_regulation (increase) of GH
5) Confidence 0.69 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.45
Administration of the serotonin precursor 5-hydroxytryptophan or morphine increased serum GH in pups of all ages.
Positive_regulation (increased) of GH associated with serotonin and morphine
6) Confidence 0.69 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.41
Pentobarbital decreased serum GH in 5-day-old pups but increased GH in 15-, 20- and 35-day-old pups.
Positive_regulation (increased) of GH
7) Confidence 0.69 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.49
Clonidine decreased serum GH in 5- and 10-day-old pups and did not increase serum GH until pups were 35 days old.
Neg (not) Positive_regulation (increase) of GH associated with clonidine
8) Confidence 0.69 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.50
Administration of somatostatin antiserum resulted in rapid elevations of plasma GH in reserpine-pretreated rats with peak levels at 30 min.
Positive_regulation (elevations) of GH in plasma associated with somatostatin
9) Confidence 0.69 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.25
GH levels then fell but remained slightly elevated for the duration of the sampling period (8 h).
Positive_regulation (elevated) of GH
10) Confidence 0.69 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.26
When clonidine (15 micrograms/100 g body weight) was injected intravenously into control rats at 14.00 h in the interval between two anticipated spontaneous GH bursts, plasma GH was increased with a mean peak value 20 min after the injection, and the following anticipated spontaneous GH burst was not observed during the experiment.
Positive_regulation (increased) of GH in plasma associated with body weight and clonidine
11) Confidence 0.68 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.25 Pain Relevance 0.59
The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.
Positive_regulation (induced) of GH associated with hypoglycemia
12) Confidence 0.67 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.19 Pain Relevance 0.51
In male Wistar rats morphine (3 mg/kg s.c.), and clonidine (31 micrograms/kg i.p.) induced a significant increase in plasma GH levels.
Positive_regulation (increase) of GH in plasma associated with clonidine and morphine
13) Confidence 0.67 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.05
The injection of yohimbine (3 mg/kg, i.p.) strongly inhibited the secretion of GH induced by clonidine treatment in sham-operated animals, and its inhibitory action was significantly attenuated in castrates.
Positive_regulation (induced) of GH associated with clonidine
14) Confidence 0.67 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.41 Pain Relevance 0.76
The alpha receptor agonist clonidine (CLON) given to reserpine-pretreated animals induced a dose-dependent increase in plasma GH.
Positive_regulation (increase) of GH in plasma associated with agonist and clonidine
15) Confidence 0.67 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6291085 Disease Relevance 0 Pain Relevance 0.76
In intact urethane-anesthetized rats, plasma growth hormone (GH) levels were low but increased significantly following intravenous injection of chlorpromazine.
Positive_regulation (increased) of GH in plasma
16) Confidence 0.67 Published 1975 Journal Endocrinol. Jpn. Section Abstract Doc Link 1097237 Disease Relevance 0 Pain Relevance 0
Intravenous injection of chlorpromazine caused an increase of plasma GH in rats with any type of hypothalamic cut.
Positive_regulation (increase) of GH in plasma
17) Confidence 0.67 Published 1975 Journal Endocrinol. Jpn. Section Abstract Doc Link 1097237 Disease Relevance 0 Pain Relevance 0
Ten minutes after the infusion, plasma GH was increased from the resting value of 28.5 +/- 7.1 ng/ml (mean +/- SE) to 686.1 +/- 62.0 ng/ml.
Positive_regulation (increased) of GH in plasma
18) Confidence 0.67 Published 1988 Journal Endocrinology Section Abstract Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.36
In rats anesthetized with ketamine, which induces a significant increase of GH, PRL and corticosterone secretion by activating the sympathetic tone, OFQ (23 microg/rat, i.c.v.) did not modify GH and corticosterone levels, whereas again it significantly potentiated PRL secretion.
Positive_regulation (increase) of GH in sympathetic associated with ketamine
19) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031535 Disease Relevance 0 Pain Relevance 0.38
In contrast, alprazolam caused a dose-dependent increase in plasma GH when given alone to reserpine pretreated rats.
Positive_regulation (increase) of GH in plasma
20) Confidence 0.66 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.41

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