INT8741

Context Info Confidence 0.41 First Reported 1984 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.36 Pain Relevance 1.67

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)

Anatomy Link Frequency nerves 2 Ins1 (Mus musculus)

Pain Link Frequency Relevance Heat narcan 7 99.66 qutenza 8 99.60 Neuropeptide 1 99.24 agonist 17 99.20 Cholecystokinin 1 96.76 Endogenous opioid 1 90.40 tolerance 19 89.80 Calcitonin gene-related peptide 3 84.20 opiate 3 81.00 substance P 2 80.68

Disease Link Frequency Relevance Heat Insulin Resistance 39 100.00 Hyperinsulinism 4 100.00 Obesity 59 99.10 Polycystic Ovary Syndrome 6 98.08 Impaired Glucose Tolerance 19 89.80 Hyperglycemia 3 70.40 Atherosclerosis 21 52.96 Cardiovascular Disease 15 50.00 INFLAMMATION 6 36.96 Hypogonadotropic Hypogonadism 1 35.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the contrary, naloxone had no apparent effect on the insulin secretory response to the cholinergic agonist carbachol or the synthetic C-terminal octapeptide of cholecystokinin, CCK-8.

Neg (no) Regulation (effect) of Positive_regulation (response) of insulin associated with agonist, narcan and cholecystokinin

1) Confidence 0.41 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.81

Moreover, alternative mechanisms responsible for the induction of insulin resistance could play a role in peripheral tissues.

Regulation (responsible) of Positive_regulation (induction) of insulin associated with insulin resistance

2) Confidence 0.23 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.55 Pain Relevance 0

Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.

Regulation (effects) of Positive_regulation (induced) of insulin in nerves associated with qutenza

3) Confidence 0.19 Published 1992 Journal J. Auton. Nerv. Syst. Section Title Doc Link 1378463 Disease Relevance 0.07 Pain Relevance 0.82

Key mediators of insulin and glucose metabolism such as the retinol-binding protein 4 (RBP4) were also regulated in ?

Regulation (regulated) of Positive_regulation (mediators) of insulin

4) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0

Insulin infusion in obese men can increase testosterone levels, while increased insulin levels have been shown to contribute to increased androgen production in women with PCOS [16,17].

Regulation (contribute) of Positive_regulation (increased) of insulin associated with obesity, polycystic ovary syndrome and hyperinsulinism

5) Confidence 0.08 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2693125 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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