INT8741

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.36
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
nerves 2
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 7 99.66 Very High Very High Very High
qutenza 8 99.60 Very High Very High Very High
Neuropeptide 1 99.24 Very High Very High Very High
agonist 17 99.20 Very High Very High Very High
Cholecystokinin 1 96.76 Very High Very High Very High
Endogenous opioid 1 90.40 High High
tolerance 19 89.80 High High
Calcitonin gene-related peptide 3 84.20 Quite High
opiate 3 81.00 Quite High
substance P 2 80.68 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 39 100.00 Very High Very High Very High
Hyperinsulinism 4 100.00 Very High Very High Very High
Obesity 59 99.10 Very High Very High Very High
Polycystic Ovary Syndrome 6 98.08 Very High Very High Very High
Impaired Glucose Tolerance 19 89.80 High High
Hyperglycemia 3 70.40 Quite High
Atherosclerosis 21 52.96 Quite High
Cardiovascular Disease 15 50.00 Quite Low
INFLAMMATION 6 36.96 Quite Low
Hypogonadotropic Hypogonadism 1 35.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, naloxone had no apparent effect on the insulin secretory response to the cholinergic agonist carbachol or the synthetic C-terminal octapeptide of cholecystokinin, CCK-8.
Neg (no) Regulation (effect) of Positive_regulation (response) of insulin associated with agonist, narcan and cholecystokinin
1) Confidence 0.41 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.81
Moreover, alternative mechanisms responsible for the induction of insulin resistance could play a role in peripheral tissues.
Regulation (responsible) of Positive_regulation (induction) of insulin associated with insulin resistance
2) Confidence 0.23 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.55 Pain Relevance 0
Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.
Regulation (effects) of Positive_regulation (induced) of insulin in nerves associated with qutenza
3) Confidence 0.19 Published 1992 Journal J. Auton. Nerv. Syst. Section Title Doc Link 1378463 Disease Relevance 0.07 Pain Relevance 0.82
Key mediators of insulin and glucose metabolism such as the retinol-binding protein 4 (RBP4) were also regulated in ?
Regulation (regulated) of Positive_regulation (mediators) of insulin
4) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Insulin infusion in obese men can increase testosterone levels, while increased insulin levels have been shown to contribute to increased androgen production in women with PCOS [16,17].
Regulation (contribute) of Positive_regulation (increased) of insulin associated with obesity, polycystic ovary syndrome and hyperinsulinism
5) Confidence 0.08 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2693125 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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