INT8742

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1983
Last Reported 2011
Negated 7
Speculated 3
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 14.98
Pain Relevance 16.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreatic islets 12
nerves 8
Autonomic 6
sympathetic 6
plasma 4
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 203 100.00 Very High Very High Very High
antagonist 125 100.00 Very High Very High Very High
agonist 83 100.00 Very High Very High Very High
Clonidine 58 100.00 Very High Very High Very High
qutenza 44 100.00 Very High Very High Very High
narcan 35 100.00 Very High Very High Very High
lidocaine 20 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 209 99.80 Very High Very High Very High
Hypoglycemia 77 99.80 Very High Very High Very High
Diabetes Mellitus 952 99.76 Very High Very High Very High
Targeted Disruption 546 99.60 Very High Very High Very High
Hyperglycemia 108 99.34 Very High Very High Very High
Apoptosis 19 99.10 Very High Very High Very High
Obesity 589 98.66 Very High Very High Very High
Body Weight 120 98.48 Very High Very High Very High
Bordatella Infection 9 98.24 Very High Very High Very High
Systemic Lupus Erythematosus 6 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SL 84.0418 (2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3, 2,1- hi]-indole hydrocholoride) is a novel alpha 2-adrenoceptor antagonist which possesses anti-hyperglycaemic properties in vitro study, we tested its effects on insulin release from isolated mouse islets.
Regulation (effects) of Localization (release) of insulin associated with antagonist
1) Confidence 0.61 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0 Pain Relevance 0.34
Autonomic regulation of insulin secretion is changed by pentobarbital in mice.
Regulation (regulation) of Localization (secretion) of insulin in Autonomic associated with anesthesia
2) Confidence 0.60 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20471451 Disease Relevance 0.07 Pain Relevance 0.21
It has been established that insulin secretion is regulated by autonomic nervous homeostasis.
Regulation (regulated) of Localization (secretion) of insulin in autonomic
3) Confidence 0.60 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0 Pain Relevance 0.07
In conclusion, the obtained results suggest that insulin secretion regulated by autonomic nervous homeostasis can be changed by pentobarbital through decrement in sympathetic tone to increase the insulin secretion induced by agent(s) via higher of parasympathetic tone.
Regulation (regulated) of Localization (secretion) of insulin in sympathetic
4) Confidence 0.60 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0.08 Pain Relevance 0.12
Lidocaine, 1-5 mM, stimulated basal insulin release, but 1 microM-1 mM of the drug did not affect glucose-induced (20 mM glucose) insulin release and 5 mM lidocaine inhibited glucose stimulation.
Neg (not) Regulation (affect) of Localization (release) of insulin associated with lidocaine
5) Confidence 0.60 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.57
Effect of tetracaine and lidocaine on insulin release in isolated mouse pancreatic islets.
Regulation (Effect) of Localization (release) of insulin in pancreatic islets associated with lidocaine
6) Confidence 0.60 Published 1983 Journal Biochim. Biophys. Acta Section Title Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.39
The effect of tetracaine and lidocaine on insulin secretion and glucose oxidation by islets of ob/ob-mice was measured.
Regulation (effect) of Localization (secretion) of insulin associated with lidocaine
7) Confidence 0.60 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.23
Effects of the alpha 2-adrenergic agonist clonidine on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration ([Ca2+]i) were investigated using pancreatic beta-cells isolated from obese hyperglycemic mice.
Spec (investigated) Regulation (Effects) of Localization (release) of insulin associated with obesity, agonist and clonidine
8) Confidence 0.60 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2892833 Disease Relevance 0.09 Pain Relevance 0.32
The effects of the nonmetabolizable amino acid alpha-aminoisobutyric acid (AIB) on insulin release were evaluated using beta cell-rich pancreatic islets from ob/ob mice.
Regulation (effects) of Localization (release) of insulin in pancreatic islets associated with obesity
9) Confidence 0.58 Published 1997 Journal Pancreas Section Abstract Doc Link 8981509 Disease Relevance 0.10 Pain Relevance 0.07
These results indicate that tolbutamide and diazoxide affect insulin secretion by changing the concentration, not the action, of Ca2+ in beta-cells.
Regulation (affect) of Localization (secretion) of insulin
10) Confidence 0.57 Published 1998 Journal Diabetes Section Abstract Doc Link 9519741 Disease Relevance 0 Pain Relevance 0.09
The effect on insulin secretion paralleled that on [Ca2+]i.
Regulation (effect) of Localization (secretion) of insulin
11) Confidence 0.57 Published 1998 Journal Diabetes Section Abstract Doc Link 9519741 Disease Relevance 0 Pain Relevance 0
Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice.
Regulation (Involvement) of Localization (secretion) of insulin in nerves associated with qutenza, tolerance and impaired glucose tolerance
12) Confidence 0.57 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7943418 Disease Relevance 0.26 Pain Relevance 1.04
Further, they seem to have the capability to modulate the insulin release stimulated by glucose or beta-adrenoceptor agonists.
Regulation (modulate) of Localization (release) of insulin associated with agonist
13) Confidence 0.56 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.74
Effects of naloxone on basal and stimulated insulin secretion in the mouse.
Regulation (Effects) of Localization (secretion) of insulin associated with narcan
14) Confidence 0.56 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.83
The results suggest that TRH is able to physiologically oppose clonidine-induced hyperglycemia by acting in a specific and durable manner upon central mechanisms which modulate insulin secretion.
Regulation (modulate) of Localization (secretion) of insulin associated with hyperglycemia and clonidine
15) Confidence 0.56 Published 1988 Journal Peptides Section Abstract Doc Link 3138675 Disease Relevance 0.26 Pain Relevance 0.51
Insulin receptor substrate 2-dependent signaling in pancreatic islets is required not only for the maintenance of normal alpha and beta-cell mass, but is also involved in the regulation of insulin secretion [50, 51].
Regulation (regulation) of Localization (secretion) of insulin in pancreatic islets
16) Confidence 0.48 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.65 Pain Relevance 0
The effects of two kappa-opiate agonists, U 50488h and dynorphin A1-13, on plasma insulin and glucose concentrations in vivo and insulin release in vitro were tested in fasted genetically obese (ob/ob) and lean (+/+) mice at 12-15 wk of age.
Regulation (effects) of Localization (release) of insulin in plasma associated with dynorphin, obesity, agonist and opiate
17) Confidence 0.45 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.17 Pain Relevance 0.26
Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.
Regulation (effects) of Localization (secretion) of insulin in nerves associated with qutenza
18) Confidence 0.44 Published 1992 Journal J. Auton. Nerv. Syst. Section Title Doc Link 1378463 Disease Relevance 0.07 Pain Relevance 0.83
Effects of alpha-adrenoceptor agonists and antagonists on insulin secretion, calcium uptake, and rubidium efflux in mouse pancreatic islets.
Regulation (Effects) of Localization (secretion) of insulin in pancreatic islets associated with antagonist and agonist
19) Confidence 0.41 Published 1983 Journal Acta Physiol. Scand. Section Title Doc Link 6137936 Disease Relevance 0.09 Pain Relevance 0.52
In order to investigate the in vivo importance of endogenous opiate receptor agonists on basal and stimulated insulin secretion, the effect on plasma insulin of opiate receptor blockade by naloxone was studied in the mouse.
Spec (investigate) Regulation (importance) of Localization (secretion) of insulin in plasma associated with narcan, agonist and opiate
20) Confidence 0.41 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6090153 Disease Relevance 0 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox