INT87420

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 56
Total Number 58
Disease Relevance 48.84
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
Anatomy Link Frequency
astrocytes 4
cleavage 2
epithelial cells 2
ducts 2
colon 1
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 44 99.80 Very High Very High Very High
dexamethasone 83 98.62 Very High Very High Very High
Chronic pancreatitis 5 98.52 Very High Very High Very High
aspirin 6 97.92 Very High Very High Very High
Paracetamol 12 97.88 Very High Very High Very High
Inflammation 156 92.48 High High
cytokine 80 92.04 High High
antagonist 94 91.12 High High
Central nervous system 68 90.16 High High
Taxol 2 89.60 High High
Disease Link Frequency Relevance Heat
Apoptosis 1653 100.00 Very High Very High Very High
Lymphatic System Cancer 44 100.00 Very High Very High Very High
Lung Cancer 585 99.84 Very High Very High Very High
Carcinoma 122 99.84 Very High Very High Very High
Colon Cancer 77 99.68 Very High Very High Very High
Atherosclerosis 9 99.60 Very High Very High Very High
Death 342 99.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 94 99.40 Very High Very High Very High
Nasopharynx Cancer 294 99.24 Very High Very High Very High
Myeloid Leukemia 80 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous study demonstrated that NSAIDs require the proapoptotic B-cell non-Hodgkin lymphoma-2 (Bcl-2) family member Bcl-2-associated x protein (BAX) to induce apoptosis and inhibit the expression of antiapoptotic basal cell lymphoma-extra large (Bcl-X(L)) in colon cancer cells.
Gene_expression (expression) of Bcl-X in colon associated with lymphatic system cancer, colon cancer, cinod, hodgkin's disease and apoptosis
1) Confidence 0.75 Published 2008 Journal Nutr Cancer Section Abstract Doc Link 19003586 Disease Relevance 1.18 Pain Relevance 0.90
Nevertheless, celecoxib at both concentrations induced a strong NFkappaB activation, with increased expression of NFkappaB-dependent genes, such as bcl-2, bcl-XL and survivin.
Gene_expression (expression) of bcl-XL
2) Confidence 0.75 Published 2007 Journal Oncol. Rep. Section Abstract Doc Link 17342322 Disease Relevance 0.99 Pain Relevance 0.28
Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas.
Gene_expression (expression) of bcl-x in pancreas associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.72 Published 2001 Journal Pancreatology Section Title Doc Link 12120204 Disease Relevance 0.19 Pain Relevance 0.10
NSAIDs inhibited the expression of the antiapoptotic protein Bcl-XL, resulting in an altered ratio of BAX to Bcl-XL and subsequent mitochondria-mediated cell death.
Gene_expression (expression) of Bcl-XL associated with cinod and death
4) Confidence 0.66 Published 2000 Journal Science Section Abstract Doc Link 11062132 Disease Relevance 0.89 Pain Relevance 0.30
An immunohistochemical study showed that the lymphoma cells were positive for leukocyte common antigen, Epstein-Barr virus, bax. and bcl-XL, and negative for L-26 and bcl-2.
Neg (negative) Gene_expression (positive) of bcl-XL in leukocyte associated with lymphatic system cancer
5) Confidence 0.65 Published 1999 Journal Brain Tumor Pathol Section Abstract Doc Link 10746967 Disease Relevance 1.12 Pain Relevance 0.24
The highest upregulated miRNA at this transition, miR-184, shows a high likelihood of binding to Bcl2l1, a gene which has been shown to be co-expressed with GFAP in various samples of astrocyte tissue [36].
Gene_expression (expressed) of Bcl2l1 in astrocyte
6) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.12 Pain Relevance 0.03
Overexpression of the antiapoptotic protein Bcl-XL prevented these various apoptotic events induced by acetaminophen in Jurkat cells.
Gene_expression (Overexpression) of Bcl-XL associated with paracetamol and apoptosis
7) Confidence 0.61 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12005112 Disease Relevance 0.60 Pain Relevance 0.85
Data from the same group show that the anti-apoptotic proteins Bcl-X and Mcl-1 and the pro-apoptotic protein Bax are co-expressed in MM, with less frequent expression of another anti-apoptotic protein, Bcl-2 (Soini, 1999).
Gene_expression (expressed) of Bcl-X associated with lung cancer and apoptosis
8) Confidence 0.58 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.34 Pain Relevance 0
Data from the same group show that the anti-apoptotic proteins Bcl-X and Mcl-1 and the pro-apoptotic protein Bax are co-expressed in MM, with less frequent expression of another anti-apoptotic protein, Bcl-2 (Soini, 1999).
Gene_expression (-) of Bcl-X associated with lung cancer and apoptosis
9) Confidence 0.58 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.33 Pain Relevance 0
Differential survival of individual patients was predicted by the relative level of bcl-x expression but not bax or bak, such that strong expression of bcl-x was associated with a median postoperative survival of 171 days when compared with 912 days for diminished expression (p < 0.001) of bcl-x.
Gene_expression (expression) of bcl-x
10) Confidence 0.56 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.05 Pain Relevance 0
In pancreatic ductal adenocarcinoma and ampullary cancer, bcl-2 was not detected compared with expression seen in normal acini (p < 0.01), minor (p < 0.001) and major ducts (p < 0.01), bax expression was reduced with respect to minor ducts (p < 0.01) but no different from normal acini or major ducts. bak and bcl-x were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts (p < 0.01).
Gene_expression (expressed) of bcl-x in ducts
11) Confidence 0.56 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.06 Pain Relevance 0
In this study, BCL2L1 protein levels were found to be much higher than GFAP, suggesting a potentially strong role for this gene in astrocytes.
Gene_expression (levels) of BCL2L1 protein in astrocytes
12) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.14 Pain Relevance 0.03
The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.
Gene_expression (expression) of Bcl-xL associated with apoptosis
13) Confidence 0.56 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.12 Pain Relevance 0.05
Knockdown of bcl-xL expression with RNAi induced NPC cells apoptosis, suggesting that the siRNA technique could provide a new method for anti-NPC gene therapy [34].
Gene_expression (expression) of bcl-xL associated with nasopharynx cancer and apoptosis
14) Confidence 0.51 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.33 Pain Relevance 0
The highest upregulated miRNA (miR-184) at the GP-early OP transition shows a strong conserved 8mer binding site to BCL2-like 1 (Bcl2l1), a gene highly expressed in astrocytes [36].
Gene_expression (expressed) of Bcl2l1 in astrocytes
15) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0 Pain Relevance 0.04
The highest upregulated miRNA (miR-184) at the GP-early OP transition shows a strong conserved 8mer binding site to BCL2-like 1 (Bcl2l1), a gene highly expressed in astrocytes [36].
Gene_expression (expressed) of BCL2-like in astrocytes
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0 Pain Relevance 0.04
RESULTS: In normal pancreas and chronic pancreatitis tissues, bcl-2, bax and bcl-x were predominantly expressed in ductal epithelial cells while p53 was not detected.
Gene_expression (expressed) of bcl-x in epithelial cells
17) Confidence 0.49 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: Pancreatic and ampullary cancer are associated with absent bcl-2 expression. bax, bak and bcl-x expression was reduced compared with normal minor ducts whilst bak and bcl-x expression was increased when compared with major ducts. bcl-x expression correlates with survival following resection and may represent a potential prognosis marker.


Gene_expression (expression) of bcl-x in ducts
18) Confidence 0.49 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0 Pain Relevance 0
Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL.
Gene_expression (role) of Bcl-XL associated with atherosclerosis and apoptosis
19) Confidence 0.48 Published 2005 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 16005468 Disease Relevance 1.14 Pain Relevance 0
Activation of the apoptotic/survival machinery was also observed, whereby celecoxib treatment induced expression of genes encoding such products as cytochrome C oxidase subunit VIII, BAX, BCLxs, presenillin 2 (structural protein from cleavage of death substrate), apoptotic chromatin condensation inducer, and PDCD5 (programmed cell death 5).
Gene_expression (expression) of BCLxs in cleavage associated with apoptosis and death
20) Confidence 0.44 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.51 Pain Relevance 0.07

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