INT87434

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 21.95
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophil 9
T cells 5
platelets 3
mononuclear phagocyte 3
endothelial cells 3
Sell (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 160 99.92 Very High Very High Very High
Inflammatory stimuli 10 99.26 Very High Very High Very High
cINOD 22 99.00 Very High Very High Very High
Infliximab 14 98.78 Very High Very High Very High
reflex sympathetic dystrophy 7 97.84 Very High Very High Very High
aspirin 23 97.60 Very High Very High Very High
Morphine 7 97.36 Very High Very High Very High
Inflammatory response 97 96.04 Very High Very High Very High
Angina 6 95.44 Very High Very High Very High
Inflammation 850 94.40 High High
Disease Link Frequency Relevance Heat
Adhesions 261 100.00 Very High Very High Very High
Coronary Artery Disease 40 99.92 Very High Very High Very High
Targeted Disruption 56 99.80 Very High Very High Very High
Stress 48 99.20 Very High Very High Very High
INFLAMMATION 870 99.08 Very High Very High Very High
Infection 182 98.36 Very High Very High Very High
Cv Unclassified Under Development 146 98.16 Very High Very High Very High
Complex Regional Pain Syndromes 7 97.84 Very High Very High Very High
Viral Infection 17 96.00 Very High Very High Very High
Cold Sores 5 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that diphenylamine seems to be the structural core of NSAIDs accounting for their down-regulatory activity of L-selectin leukocyte expression.
Gene_expression (expression) of L-selectin in leukocyte associated with cinod
1) Confidence 0.77 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12147693 Disease Relevance 0.41 Pain Relevance 0.40
The presence of a carboxylic acid group in the diphenylamine (N-phenylanthranilic acid) highly increased its ability to reduce the L-selectin surface expression in neutrophils.
Gene_expression (expression) of L-selectin in neutrophils
2) Confidence 0.77 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12147693 Disease Relevance 0.55 Pain Relevance 0.66
Microarray analysis of Peyer's patch cells revealed enhanced expression of L-selectin gene.
Gene_expression (expression) of L-selectin in Peyer's patch
3) Confidence 0.58 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2816392 Disease Relevance 0.15 Pain Relevance 0.05
To investigate the possible effects of MC3R gene ablation on adhesion molecule expression on circulating leukocytes during I/R, we investigated the expression of CD11b and CD62L on granulocytes (GR-1hi) and mononuclear phagocytes (F4/80+).
Spec (investigated) Gene_expression (expression) of CD62L in mononuclear phagocytes associated with adhesions
4) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0.03
I/R leads to a nonsignificant decrease in CD62L expression in WT F4/80 cells, whereas a significant decrease in CD62L expression was observed in MC3R-null animals (Table 3), suggesting that the mononuclear phagocyte compartment is highly activated in the MC3R-null animals after I/R.


Gene_expression (expression) of CD62L in mononuclear phagocyte
5) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.20 Pain Relevance 0
Indeed, whereas no changes of CD11b and CD62L expression could be measured in circulating PMN, a lower degree of expression was measured in circulating F4/80+ cells selectively after I/R.
Gene_expression (expression) of CD62L in F4/80
6) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.61 Pain Relevance 0.30
I/R leads to a nonsignificant decrease in CD62L expression in WT F4/80 cells, whereas a significant decrease in CD62L expression was observed in MC3R-null animals (Table 3), suggesting that the mononuclear phagocyte compartment is highly activated in the MC3R-null animals after I/R.


Gene_expression (expression) of CD62L in mononuclear phagocyte
7) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.19 Pain Relevance 0
Whereas MCP-1 and KC could not be detected, soluble CD62L, IL-1, and TNF-?
Neg (not) Gene_expression (detected) of CD62L
8) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.07
The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice.
Gene_expression (expressions) of CD62L associated with aspirin
9) Confidence 0.51 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.21 Pain Relevance 0.69
All neutrophil populations were stained for surface expression of CD11b (PE-conjugated, clone 2LPM19c, 2 µg/ml; DAKO) or CD62L (FITC-conjugated, clone Dreg56,10 µg/ml, Beckton Dickinson).
Gene_expression (expression) of CD62L in neutrophil
10) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.06 Pain Relevance 0
2 integrin CD11b/CD18 that is required for efficient neutrophil transmigration) and proteolytically shed l-selectin (Figure 8).
Gene_expression (/) of l-selectin in neutrophil
11) Confidence 0.48 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.08
A subset of CD11c- CD8+ T cells expressed high levels of the activation marker CD69 and low levels of CD62L.
Gene_expression (expressed) of CD62L in T cells
12) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.46 Pain Relevance 0
Postsinusoidal rolling was further reduced to baseline following injection of an anti-P-selectin or anti-L-selectin MAb.
Gene_expression (injection) of L-selectin
13) Confidence 0.38 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.50 Pain Relevance 0.20
The authors showed that infliximab treatment induced differentiation of a Treg cell population expressing FoxP3 and low levels of CD62L through conversion of CD4+CD25- T cells.
Gene_expression (expressing) of CD62L in T cells associated with infliximab
14) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.47 Pain Relevance 0.42
There was no upregulation of Mac-1 (CD11b/ CD18) or shedding of L-selectin on circulating neutrophils.
Gene_expression (shedding) of L-selectin in neutrophils
15) Confidence 0.37 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10774834 Disease Relevance 0.99 Pain Relevance 0.74
CO had no impact on L-selectin expression, but tended to reduce CD11b expression on lung-marginated neutrophils.
Gene_expression (expression) of L-selectin in lung
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.08 Pain Relevance 0.04
We also investigated potential changes in the levels of neutrophil activation in terms of surface expression of L-selectin and CD11b (fig. 8).
Gene_expression (expression) of L-selectin in neutrophil
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.12 Pain Relevance 0.03
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Gene_expression (expression) of L-selectin in neutrophils
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.08 Pain Relevance 0.04
CD62L is expressed at high levels on naïve and memory T cells and down-regulated on effector T cells.
Gene_expression (expressed) of CD62L in memory T cells
19) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.27 Pain Relevance 0
plays the key role in attracting and activating lymphocytes [46,47], we observed that expression of T-cell surface markers Icam1 [48,49] and Cd86 and ligands (Sell) [50] peaked at week 13 in infected mice.
Gene_expression (expression) of Sell in T-cell
20) Confidence 0.35 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.55 Pain Relevance 0.16

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