INT8744

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 2.06
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
nerves 4
blood 2
plasma 2
alpha cells 2
skeletal muscles 2
Gcg (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 16 99.60 Very High Very High Very High
Neuropeptide 2 99.24 Very High Very High Very High
member 8 6 98.08 Very High Very High Very High
Paracetamol 36 97.20 Very High Very High Very High
agonist 13 94.88 High High
tetrodotoxin 7 92.72 High High
substance P 4 91.88 High High
Calcitonin gene-related peptide 6 91.20 High High
Clonidine 9 91.12 High High
Somatostatin 18 87.12 High High
Disease Link Frequency Relevance Heat
Hypoglycemia 7 100.00 Very High Very High Very High
Hyperglycemia 6 100.00 Very High Very High Very High
Targeted Disruption 75 94.32 High High
Diabetes Mellitus 13 91.32 High High
Abdominal Pain 1 85.00 Quite High
Vomiting 3 83.96 Quite High
Diarrhoea 1 83.40 Quite High
Muscular Spasm 1 82.00 Quite High
Gastrointestinal Disease 1 82.00 Quite High
Cushing's Syndrome /

Hypercortisolism

30 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we investigated how adrenaline affects the cytoplasmic Ca2+ concentration, which controls glucagon secretion from the pancreatic alpha-cell.
Regulation (controls) of Localization (secretion) of glucagon
1) Confidence 0.60 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14727006 Disease Relevance 0 Pain Relevance 0.09
Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (KATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells.
Regulation (control) of Localization (secretion) of glucagon in plasma
2) Confidence 0.56 Published 2004 Journal Diabetes Section Abstract Doc Link 15561909 Disease Relevance 0 Pain Relevance 0
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Regulation (regulation) of Localization (release) of glucagon
3) Confidence 0.56 Published 2004 Journal Diabetes Section Title Doc Link 15561909 Disease Relevance 0 Pain Relevance 0.03
We conclude that the KATP channel is involved in the control of glucagon secretion by regulating the membrane potential in the alpha-cell in a way reminiscent of that previously documented in insulin-releasing beta-cells.
Regulation (control) of Localization (secretion) of glucagon
4) Confidence 0.56 Published 2004 Journal Diabetes Section Abstract Doc Link 15561909 Disease Relevance 0 Pain Relevance 0.19
Furthermore, capsaicin-sensitive sensory nerve fibers are partially involved in 2-DG-induced glucagon secretion and hyperglycemia, whereas sensory nerves are not involved in 2-DG-induced insulin secretion.
Neg (not) Regulation (involved) of Localization (secretion) of glucagon in sensory nerves associated with hyperglycemia and qutenza
5) Confidence 0.42 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1378463 Disease Relevance 0.18 Pain Relevance 0.78
Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.
Regulation (effects) of Localization (secretion) of glucagon in nerves associated with qutenza
6) Confidence 0.42 Published 1992 Journal J. Auton. Nerv. Syst. Section Title Doc Link 1378463 Disease Relevance 0.07 Pain Relevance 0.83
Effect of nerve blockade on pulsatile insulin and glucagon secretion in vitro.
Regulation (Effect) of Localization (secretion) of glucagon in nerve
7) Confidence 0.40 Published 1991 Journal Pancreas Section Title Doc Link 1780325 Disease Relevance 0 Pain Relevance 0.31
Here we have explored the effects of CDS on glucagon release from mouse pancreatic alpha-cells.
Regulation (effects) of Localization (release) of glucagon
8) Confidence 0.38 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11606044 Disease Relevance 0 Pain Relevance 0.17
The effects of activation of the alpha-adrenoceptors on glucagon secretion are not yet clear.
Regulation (effects) of Localization (secretion) of glucagon
9) Confidence 0.25 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2891547 Disease Relevance 0 Pain Relevance 0.42
in gastric emptying would be a mechanism for changes in glucagon secretion
Regulation (changes) of Localization (secretion) of glucagon
10) Confidence 0.23 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2443691 Disease Relevance 0.15 Pain Relevance 0.50
in view of the inhibitory influence of insulin on glucagon secretion.
Regulation (influence) of Localization (secretion) of glucagon
11) Confidence 0.23 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2443691 Disease Relevance 0.19 Pain Relevance 0.19
The counterregulatory measures that occur upon low blood glucose levels are the following: insulin secretion, glucagon secretion, epinephrine secretion (if needed), and, lastly, stimulation of food intake.
Regulation (following) of Localization (secretion) of glucagon in blood
12) Confidence 0.19 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.22 Pain Relevance 0
The Kir6.2-containing K(ATP) channels in pancreatic ss-cells and the hypothalamus are essential in the regulation of glucose-induced insulin secretion and hypoglycemia-induced glucagon secretion, respectively, and are involved in glucose uptake in skeletal muscles, thus playing a key role in the maintenance of glucose homeostasis.
Regulation (regulation) of Localization (secretion) of glucagon in skeletal muscles associated with hypoglycemia
13) Confidence 0.14 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15910876 Disease Relevance 0.43 Pain Relevance 0.11
AIMS/HYPOTHESIS: Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion from alpha cells.
Spec (may) Regulation (regulate) of Localization (secretion) of glucagon in alpha cells
14) Confidence 0.10 Published 2010 Journal Diabetologia Section Abstract Doc Link 20424817 Disease Relevance 0.16 Pain Relevance 0.49
Analysis of insulin and glucagon levels at baseline vs during treatment indicated that pasireotide administration was followed by initial suppression of insulin but did not significantly influence glucagon release.
Neg (not) Regulation (influence) of Localization (release) of glucagon
15) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.57 Pain Relevance 0.19

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