INT87451

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 12.82
Pain Relevance 10.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) protein complex assembly (Mapk3) protein complex (Mapk3)
cytoplasm (Mapk3) cytosol (Mapk3) signal transduction (Mapk3)
Anatomy Link Frequency
spinal cord 4
liver 2
nucleus 2
spinal 2
mesangial cells 2
Mapk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 63 100.00 Very High Very High Very High
neuralgia 7 100.00 Very High Very High Very High
Neuropathic pain 9 99.84 Very High Very High Very High
Pain 34 99.76 Very High Very High Very High
agonist 53 99.70 Very High Very High Very High
Dorsal horn 9 99.68 Very High Very High Very High
Morphine 32 99.64 Very High Very High Very High
Spinal cord 51 99.32 Very High Very High Very High
nMDA receptor 59 99.28 Very High Very High Very High
fibrosis 4 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 99.84 Very High Very High Very High
Pain 34 99.32 Very High Very High Very High
Fibrosis 6 99.24 Very High Very High Very High
INFLAMMATION 44 98.92 Very High Very High Very High
Hepatocellular Cancer 110 98.24 Very High Very High Very High
Stress 28 96.48 Very High Very High Very High
Apoptosis 177 96.32 Very High Very High Very High
Targeted Disruption 29 95.36 Very High Very High Very High
Nociception 61 94.48 High High
Diabetes Mellitus 56 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Reg2-/- mice, liver regeneration was markedly impaired, with 29% mortality and delay of the S-phase and the activation of ERK1/2 and AKT.
Positive_regulation (activation) of ERK1 in liver
1) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.53 Pain Relevance 0.07
Longer periods were not investigated [20], and neither was the time-variation of the activation of ERK1/2 by low doses of NMDA.
Positive_regulation (activation) of ERK1
2) Confidence 0.67 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.19
Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse.
Positive_regulation (increased) of p44/42 MAP kinase in nucleus associated with pain
3) Confidence 0.63 Published 2000 Journal Brain Res. Section Title Doc Link 10751581 Disease Relevance 0.17 Pain Relevance 0.20
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (activation) of ERK1 in spinal cord associated with spinal cord
4) Confidence 0.55 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
These results show that mGluR1 and mGluR5 are activated in dorsal horn neurons in response to peripheral inflammation and that activation of these group I mGluRs leads to activation of ERK1 and ERK2, resulting in enhanced pain sensitivity.
Positive_regulation (activation) of ERK1 in neurons associated with pain, inflammation and dorsal horn neuron
5) Confidence 0.55 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.71 Pain Relevance 0.65
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.
Positive_regulation (activation) of ERK1 in dorsal horn associated with pain, nmda receptor and dorsal horn
6) Confidence 0.49 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16413788 Disease Relevance 1.01 Pain Relevance 1.18
Application of glutamate to hippocampal cell cultures induces an NMDA-R -dependent increase in ERK1/2 phosphorylation [34], [43].
Positive_regulation (increase) of ERK1 associated with glutamate
7) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.16
Intracolonic saline did not produce significant activation of lumbosacral spinal ERK1/2, and none of the treatments evoked ERK1/2 activation in thoracic or cervical spinal cord.
Positive_regulation (activation) of ERK1 in spinal cord associated with spinal cord
8) Confidence 0.49 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941468 Disease Relevance 0.28 Pain Relevance 0.84
In summary, our data indicate that morphine modulation of IFN-gamma promoter activity is mediated through two distinct cAMP-dependent pathways, the NF-kappaB signaling pathway and the ERK1/2, p38 MAPK, AP-1/NFAT pathway.
Positive_regulation (mediated) of ERK1 in NFAT associated with morphine
9) Confidence 0.49 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.15 Pain Relevance 0.94
Morphine inhibited phosphorylation of ERK1/2 and p38 MAPK; in addition, morphine treatment in the presence of either ERK1/2 or p38 MAPK inhibitor (PD98059 or SB203580) resulted in an additive inhibition of IFN-gamma promoter activity.
Positive_regulation (presence) of ERK1 associated with morphine
10) Confidence 0.49 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.36 Pain Relevance 1.14
Despite activation (phosphorylation) of ERK1 after acute noxious stimulation and in models of chronic pain, we found that ERK1 was not required for formalin-induced spontaneous behaviors, complete Freund's adjuvant-induced heat and mechanical hypersensitivity, and spared nerve injury-induced mechanical hypersensitivity.
Positive_regulation (activation) of ERK1 in nerve associated with nervous system injury, lasting pain and hypersensitivity
11) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20739576 Disease Relevance 1.16 Pain Relevance 0.36
Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse.
Positive_regulation (increased) of p44/42 MAP kinase in nucleus associated with pain
12) Confidence 0.45 Published 2000 Journal Brain Res. Section Title Doc Link 10751581 Disease Relevance 0.17 Pain Relevance 0.20
Inhibited the activation of p42/p44 mitogen-activated protein kinase (MAPK) by PD98059, a specific inhibitor of extracellular regulatory kinase (ERK), significantly decreased cell viability and enhanced the expression of p53 induced by ASA.
Positive_regulation (activation) of p44
13) Confidence 0.45 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.11 Pain Relevance 0
NHE inhibition suppressed both activation of the p42/p44 mitogen-activated protein kinase and nuclear factor-kappaB.
Positive_regulation (activation) of p44
14) Confidence 0.45 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.87 Pain Relevance 0.32
ERK1/2 is also activated through NMDA-dependent electrophysiological stimulating potentiation protocols [35], and by NMDA application upon hippocampal slices [20], [36].
Positive_regulation (activated) of ERK1
15) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.16
However, we do show that the contribution of the spinal cord to the reduced behavioral effect is paramount since the activation of ERK1 and ERK2 is also decreased following formalin injection in the DN MEK mice relative to wild type littermates, and the behavioral and biochemical inhibition can be mimicked by intrathecal administration of MEK inhibitors.
Positive_regulation (activation) of ERK1 in spinal cord associated with intrathecal and spinal cord
16) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.25 Pain Relevance 0.30
Here, the authors hypothesized that dexmedetomidine increases pERK1 and 2 content and examined the mechanisms involved in this effect.
Positive_regulation (increases) of pERK1
17) Confidence 0.36 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18292683 Disease Relevance 0.09 Pain Relevance 0.17
CreERT2 encodes a Cre recombinase (Cre) fused to a mutant estrogen ligand-binding domain (ERT2) that requires the presence of tamoxifen for activity.
Positive_regulation (fused) of ERT2
18) Confidence 0.30 Published 2006 Journal Genesis Section Abstract Doc Link 16850455 Disease Relevance 0.40 Pain Relevance 0
Here we show an activation of the extracellular signal-regulated kinases (ERK1 and ERK2) and the downstream nuclear targets Elk-1 and calcium/cAMP response element binding protein, in the hippocampus of cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.
Positive_regulation (activation) of ERK1 in hippocampus associated with hippocampus and hyperhomocysteinemia
19) Confidence 0.28 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.28 Pain Relevance 0.20
In the wild type mice, blots of tissue taken from the side of the spinal cord ipsilateral to the formalin injection showed significant stimulation of both ERK1 and ERK2 when compared to the contralateral side (Fig 5a and 5b), whereas ERK activation in the spinal cords from the DN MEK mice was not significantly different from their contralateral sides.
Positive_regulation (stimulation) of ERK1 in spinal cords associated with spinal cord
20) Confidence 0.28 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.07 Pain Relevance 0.21

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