INT87456

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD81) plasma membrane (CD81)
Anatomy Link Frequency
urine 1
CD81 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 5 99.28 Very High Very High Very High
addiction 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 99.84 Very High Very High Very High
Interstitial Cystitis 5 99.28 Very High Very High Very High
Metastasis 7 98.20 Very High Very High Very High
Hypoxia 7 95.80 Very High Very High Very High
Apoptosis 8 94.84 High High
Cancer 101 91.94 High High
Overactive Bladder 1 91.00 High High
Renal Cancer 55 63.84 Quite High
Reprotox - General 1 2 59.60 Quite High
Malignant Neoplastic Disease 2 17.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Regulation (regulation) of CD81 associated with hypoxia, cancer, apoptosis, adhesions and metastasis
1) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.18 Pain Relevance 0
Because bladder hydrodistention sometimes alleviates the symptoms of interstitial cystitis, we determined whether the stretch stimulus of hydrodistention alters antiproliferative factor activity and/or HB-EGF in interstitial cystitis urine specimens.
Spec (whether) Regulation (alters) of antiproliferative factor in urine associated with interstitial cystitis
2) Confidence 0.01 Published 2000 Journal J. Urol. Section Abstract Doc Link 10751853 Disease Relevance 0.52 Pain Relevance 0.43

General Comments

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