INT87457

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD81) plasma membrane (CD81)
Anatomy Link Frequency
Urine 2
CD81 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 10 99.44 Very High Very High Very High
addiction 4 39.20 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 10 99.44 Very High Very High Very High
Metastasis 7 97.88 Very High Very High Very High
Adhesions 6 92.68 High High
Adenocarcinoma 1 89.88 High High
Overactive Bladder 2 89.76 High High
Cancer 101 88.80 High High
Hematologic Neoplasms 1 87.88 High High
Lung Cancer 2 86.40 High High
Small Cell Lung Cancer 1 85.04 High High
Reprotox - General 1 2 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of CD81 was found to be associated with differentiation and metastasis of HCC (Inoue et al. 2001).
Negative_regulation (loss) of CD81 associated with metastasis
1) Confidence 0.37 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.24 Pain Relevance 0
CONCLUSIONS: Bladder stretch increased HB-EGF and conversely reduced antiproliferative factor activity in urine from patients with interstitial cystitis but not controls up to 2 weeks after distention.
Negative_regulation (reduced) of antiproliferative factor in urine
2) Confidence 0.01 Published 2000 Journal J. Urol. Section Body Doc Link 10751853 Disease Relevance 0.05 Pain Relevance 0
Urine from patients with interstitial cystitis has been shown to inhibit urothelial proliferation through a putative antiproliferative factor and to contain decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) compared to controls.
Negative_regulation (inhibit) of antiproliferative factor in Urine associated with interstitial cystitis
3) Confidence 0.01 Published 2000 Journal J. Urol. Section Abstract Doc Link 10751853 Disease Relevance 0.44 Pain Relevance 0.42

General Comments

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