INT87458

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Context Info
Confidence 0.18
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 6.02
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD81) plasma membrane (CD81)
Anatomy Link Frequency
B-cell 2
blood 1
NK cell 1
Bladder 1
CD81 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 5 99.28 Very High Very High Very High
fibrosis 16 91.68 High High
Inflammatory response 2 64.24 Quite High
Inflammation 32 63.76 Quite High
cytokine 40 62.72 Quite High
adenocard 2 10.52 Low Low
peripheral neuropathy 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 312 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 4 99.58 Very High Very High Very High
Infection 90 99.36 Very High Very High Very High
Interstitial Cystitis 5 99.28 Very High Very High Very High
Cryoglobulinemia 292 95.88 Very High Very High Very High
Lymphatic System Cancer 34 95.24 Very High Very High Very High
Syndrome 90 94.80 High High
Ulcers 8 94.56 High High
Hepatocellular Cancer 160 93.44 High High
Cirrhosis 58 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible to hypothesize that during chronic HCV infection, several factors (including the interaction between HCV E2 protein and CD81 molecule, the high viral variability, and the persistent infection of both hepatic and lymphatic cells) may favor a sustained and strong B-cell activation (Fig. 6).
CD81 molecule Binding (interaction) of in B-cell associated with hepatitis c virus infection and infection
1) Confidence 0.18 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.48 Pain Relevance 0
Another important pathogenetic factor is the interaction between HCV E2 protein and CD81 molecule, a quite ubiquitary tetraspannin present on B-cells surface [78]; the consequence may be the strong and sustained polyclonal stimulation of B-cell compartment (Fig. 6).
CD81 molecule Binding (interaction) of in B-cell associated with hepatitis c virus infection
2) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.03 Pain Relevance 0
First, HCV E2 binding to CD81 directly inhibited NK cell activity.
CD81 Binding (binding) of in NK cell associated with hepatitis c virus infection
3) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.13 Pain Relevance 0.06
In the blood of infected patients, HCV is associated with blood lipoprotein VLDL, LDL, and HDL; although the virus binds to different molecules it requires tetraspanin CD81, the scavenger receptor class B type I (SR-BI), the tight junction proteins claudin (CLDN1) and occludin [17-20] to entry into hepatocytes.
CD81 Binding (binds) of in blood associated with hepatitis c virus infection and disorder of lipid metabolism
4) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.92 Pain Relevance 0.08
Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis.
antiproliferative factor Binding (heparin-binding) of in Bladder associated with interstitial cystitis
5) Confidence 0.01 Published 2000 Journal J. Urol. Section Title Doc Link 10751853 Disease Relevance 0.46 Pain Relevance 0.45

General Comments

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