INT8746

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 50
Total Number 52
Disease Relevance 21.22
Pain Relevance 33.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerves 4
neuron 4
neuronal 3
Spinal 2
heart 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 193 100.00 Very High Very High Very High
qutenza 130 100.00 Very High Very High Very High
substance P 57 100.00 Very High Very High Very High
Neuropeptide 45 100.00 Very High Very High Very High
calcitonin gene related peptide 23 100.00 Very High Very High Very High
analgesia 28 99.96 Very High Very High Very High
Hyperalgesia 30 99.90 Very High Very High Very High
Neuropathic pain 40 99.72 Very High Very High Very High
opioid receptor 9 99.68 Very High Very High Very High
Enkephalin 11 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mrsa Infection 21 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Infection 11 99.96 Very High Very High Very High
Hyperalgesia 33 99.90 Very High Very High Very High
Neuropathic Pain 60 99.72 Very High Very High Very High
INFLAMMATION 65 99.62 Very High Very High Very High
Targeted Disruption 78 99.52 Very High Very High Very High
Diabetes Mellitus 23 99.48 Very High Very High Very High
Frailty 5 98.32 Very High Very High Very High
Pain 135 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following sciatic nerve transection or L5 spinal nerve ligation (a model of persistent neuropathic pain) significant decreases in substance P and calcitonin gene-related peptide and increases in galanin and neuropeptide Y were observed in both primary afferent neurons and the spinal cord.
Negative_regulation (decreases) of calcitonin in afferent neurons associated with spinal nerve ligature, neuropeptide, neuropathic pain, sciatic nerve, spinal cord, calcitonin gene-related peptide and substance p
1) Confidence 0.59 Published 2000 Journal Neuroscience Section Abstract Doc Link 10869852 Disease Relevance 1.23 Pain Relevance 1.58
In the present study, mice deficient in the calcitonin/alpha CGRP gene (CGRP(-/-)) displayed normal responses to noxious stimuli.
Negative_regulation (deficient) of CGRP associated with calcitonin gene-related peptide
2) Confidence 0.59 Published 2001 Journal Pain Section Abstract Doc Link 11166483 Disease Relevance 1.04 Pain Relevance 0.92
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior.
Negative_regulation (effect) of calcitonin in Neuronal associated with narcan
3) Confidence 0.56 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7796851 Disease Relevance 0 Pain Relevance 0.67
Lower levels of calcitonin gene-related peptide and substance P were identified by immunohistochemistry in dorsal root ganglia and dorsal horn of knockout mice, and the axotomy-induced down-regulation of both calcitonin gene-related peptide and substance P was accentuated in Y1 receptor knockout.
Negative_regulation (regulation) of calcitonin in dorsal root ganglia associated with targeted disruption, dorsal horn, substance p and calcitonin gene-related peptide
4) Confidence 0.54 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564642 Disease Relevance 1.19 Pain Relevance 1.12
After capsaicin stimulation (10(-6) M for 5 min), the fibers appeared depleted of CGRP with only few vesicles remaining as well as some residual staining of the axoplasm.
Negative_regulation (depleted) of CGRP in vesicles associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.52 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183508 Disease Relevance 0 Pain Relevance 1.01
Immunohistochemistry of the pancreas at 13-14 weeks of age revealed a substantial reduction of calcitonin gene-related peptide (CGRP)-immunoreactive nerves and a partial reduction of substance P-immunoreactive nerves.
Spec (partial) Negative_regulation (reduction) of CGRP in nerves associated with substance p and calcitonin gene-related peptide
6) Confidence 0.52 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1378463 Disease Relevance 0.08 Pain Relevance 0.56
Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation.
Negative_regulation (lacking) of CGRP associated with pain and inflammation
7) Confidence 0.51 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11276224 Disease Relevance 0.52 Pain Relevance 0.86
In addition, it is hypothesized that the loss of CGRP within the ventral horn may represent the loss of a trophic factor that is important to the survival motoneurons and may influence the increase of fiber densities around the dying motoneurons.
Negative_regulation (loss) of CGRP in ventral
8) Confidence 0.48 Published 1992 Journal Brain Res. Section Abstract Doc Link 1525646 Disease Relevance 0.23 Pain Relevance 0.64
Immunohistochemistry of the pancreas at 13-14 weeks of age revealed a substantial reduction of calcitonin gene-related peptide (CGRP)-immunoreactive nerves and a partial reduction of substance P-immunoreactive nerves.
Spec (partial) Negative_regulation (reduction) of gene-related peptide in nerves associated with substance p and calcitonin gene-related peptide
9) Confidence 0.45 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1378463 Disease Relevance 0.07 Pain Relevance 0.56
Administration of ruthenium red (1 mg/kg(-1), i.p.), vanilloid receptor antagonist, and sumatriptan (50 mg/kg(-1), i.p.), a CGRP release inhibitor, attenuated diabetes and SHS induced decrease in nociceptive threshold and increase in serum nitrite oxide levels.
Negative_regulation (inhibitor) of CGRP associated with nociception, sumatriptan, diabetes mellitus and antagonist
10) Confidence 0.43 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18981706 Disease Relevance 1.45 Pain Relevance 0.84
The effect of viral vector-mediated knockdown of CGRP was comparable to the effect of intrathecal application of the CGRP antagonist CGRP8-37, but lasted for 14 weeks after one single application.
Negative_regulation (knockdown) of CGRP
11) Confidence 0.43 Published 2007 Journal Anesthesiology Section Body Doc Link 17525595 Disease Relevance 0 Pain Relevance 0
RESULTS: Herpes virus-based vector encoding an antisense sequence for the whole CGRP clearly reduced CGRP immunoreactivity in the infected spinal dorsal horn levels as well as in cultured dorsal root ganglia neurons.
Negative_regulation (reduced) of CGRP in neurons
12) Confidence 0.43 Published 2007 Journal Anesthesiology Section Body Doc Link 17525595 Disease Relevance 0 Pain Relevance 0
Preconditioning with capsaicin 24 h before I/R was prevented by coincident treatment with CGRP-(8-37), while exogenous CGRP induced an anti-inflammatory phenotype in mice depleted of CGRP by capsaicin administration 4 days earlier.
Negative_regulation (depleted) of CGRP associated with inflammation, qutenza and calcitonin gene-related peptide
13) Confidence 0.43 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16143644 Disease Relevance 0.34 Pain Relevance 1.09
The 5-HT(2A-2C) agonist (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI) diminished calcitonin analgesia.
Negative_regulation (diminished) of calcitonin associated with agonist and analgesia
14) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10536192 Disease Relevance 0 Pain Relevance 1.17
The 5-HT(1A) agonist (+/-)-8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) diminished calcitonin analgesia, this effect being antagonised by the 5-HT(1A) antagonist (WAY 100, 135).
Negative_regulation (diminished) of calcitonin associated with antagonist, agonist and analgesia
15) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10536192 Disease Relevance 0 Pain Relevance 0.93
In the present study, mice deficient in the calcitonin/alpha CGRP gene (CGRP(-/-)) displayed normal responses to noxious stimuli.
Negative_regulation (deficient) of CGRP associated with calcitonin gene-related peptide
16) Confidence 0.43 Published 2001 Journal Pain Section Abstract Doc Link 11166483 Disease Relevance 1.03 Pain Relevance 0.89
Conversely, i.t. administration of agents which decrease intracellular calcium, such as EGTA and alpha-calcitonin gene-related peptide, blocked nicotine-induced antinociception.
Negative_regulation (decrease) of alpha-calcitonin associated with antinociception, nicotine and calcitonin gene-related peptide
17) Confidence 0.43 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690401 Disease Relevance 0 Pain Relevance 1.02
Blockade of CGRP and TRPV1 receptors may offer a novel strategy for the treatment of endotoxin-induced ileus.
Negative_regulation (Blockade) of CGRP associated with ileus and calcitonin gene-related peptide
18) Confidence 0.43 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19445917 Disease Relevance 0.25 Pain Relevance 0.44
A marked decrease of CGRP- and VIP-immunoreactive nerves occurred in samples from treated mice, whereas PGP-labeled profiles decreased mildly at late stages.
Negative_regulation (decrease) of CGRP in nerves associated with calcitonin gene-related peptide
19) Confidence 0.42 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10086893 Disease Relevance 0.39 Pain Relevance 0.25
Some spinal cord neuronal types, such as those storing methionine-enkephalin, substance P or calcitonin gene-related peptide were almost totally depleted after inhibition of electrical activity for 4 days.
Negative_regulation (depleted) of calcitonin in neuronal associated with enkephalin, calcitonin gene-related peptide, substance p and spinal cord
20) Confidence 0.42 Published 1989 Journal Cell Tissue Res. Section Abstract Doc Link 2472892 Disease Relevance 0.18 Pain Relevance 1.01

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