INT87468

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 10.79
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
ventricles 2
extracellular matrix 2
liver 1
muscle 1
striatum 1
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 265 100.00 Very High Very High Very High
endometriosis 170 99.86 Very High Very High Very High
dexamethasone 12 99.28 Very High Very High Very High
fibrosis 65 98.20 Very High Very High Very High
diclofenac 2 98.12 Very High Very High Very High
ischemia 16 97.60 Very High Very High Very High
Dismenorea 7 96.24 Very High Very High Very High
Pain 17 91.08 High High
cINOD 5 89.92 High High
Arthritis 14 89.00 High High
Disease Link Frequency Relevance Heat
Endometriosis 224 99.86 Very High Very High Very High
Fibrosis 62 99.58 Very High Very High Very High
Pituitary Cancer 11 99.26 Very High Very High Very High
Diabetes Mellitus 113 98.68 Very High Very High Very High
Endometriosis (extended) 3 98.32 Very High Very High Very High
Apoptosis 34 98.28 Very High Very High Very High
Cv General 4 Under Development 5 97.96 Very High Very High Very High
Cancer 117 97.84 Very High Very High Very High
Cv Unclassified Under Development 9 97.32 Very High Very High Very High
Disease 65 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naltrexone treatment in BDL rats led to a decrease in the level of liver MMP-2 activity, which had already increased during cholestasis.
Negative_regulation (decrease) of MMP-2 in liver
1) Confidence 0.57 Published 2007 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17295775 Disease Relevance 0.14 Pain Relevance 0
Moreover, GXM therapy could diminish MMP-2 activity, but it had no notable effect on apoptosis.
Negative_regulation (diminish) of MMP-2 associated with apoptosis
2) Confidence 0.43 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15320878 Disease Relevance 1.15 Pain Relevance 0.42
The inhibitory effect of M2000 in MMP-2 activity was significantly greater than that of dexamethasone and of piroxicam at a concentration of 200 microg/ml.
Negative_regulation (effect) of MMP-2 associated with dexamethasone
3) Confidence 0.38 Published 2005 Journal Scand. J. Immunol. Section Abstract Doc Link 15882435 Disease Relevance 0.49 Pain Relevance 0.39
The inhibitory effect of M2000 in MMP-2 activity was significantly greater than that of dexsamethasone and of piroxicam at a concentration of 200 microg/ml.
Negative_regulation (effect) of MMP-2
4) Confidence 0.37 Published 2007 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 17464766 Disease Relevance 0.29 Pain Relevance 0.17
Again consistent with the changes observed in the present study, from young to 24-month-old rats, Robert et al. [35] observed a 40% decrease in MMP2 activity and a corresponding decrease of MMP2 mRNA in the ventricles.
Negative_regulation (decrease) of MMP2 in ventricles
5) Confidence 0.37 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0
The abundance of MMP2 mRNA was similar in all tissues and there was a significant age-dependent decrease in MMP2 mRNA in the SAN head and atrial muscle at least (Fig. 7A).
Negative_regulation (decrease) of MMP2 mRNA in muscle
6) Confidence 0.37 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.44 Pain Relevance 0.18
Although there was a modest age-dependent decrease in MMP2 mRNA (Fig. 7A; tending to result in increase in collagen protein), there was a large age-dependent decrease of mRNAs for types 1 and 3 collagen of ? 
Negative_regulation (decrease) of MMP2 mRNA
7) Confidence 0.37 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.07 Pain Relevance 0.05
The association we found between the infants' genotypes and both the MMP16 protein level and the size of the activated MMP2 fraction in tracheal aspirates strongly suggests that these polymorphisms have functional consequences, although no definitive proof is given that the changes in MMP16 are causative of reduced MMP2 activation..
Negative_regulation (reduced) of MMP2
8) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.27 Pain Relevance 0.03
Matrix metalloproteinase (MMP) is a group of Zn-dependent proteinases activated by proteolytic removal of their amino terminal, and their actions are inhibited by specific inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP).2 MMP-2 and MMP-9 are designated as 72-kDa gelatinase A and 92-kDa gelatinase B, respectively, and well known by their ability of degrading collagen type IV, the major constituent of the basement membrane.
Negative_regulation (inhibitors) of MMP-2 in basement membrane associated with metalloproteinase
9) Confidence 0.34 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.69 Pain Relevance 0.62
Again consistent with the changes observed in the present study, from young to 24-month-old rats, Robert et al. [35] observed a 40% decrease in MMP2 activity and a corresponding decrease of MMP2 mRNA in the ventricles.
Negative_regulation (decrease) of MMP2 mRNA in ventricles
10) Confidence 0.27 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.05 Pain Relevance 0
In summary, these data provide a complex picture of age-dependent remodelling of the extracellular matrix: a modest increase in the abundance of fibrotic agents and a modest decrease in MMP2 (at mRNA level), both of which will promote fibrosis, and yet a decrease in abundance of mRNAs responsible for structural elements of the extracellular matrix.
Negative_regulation (decrease) of MMP2 in extracellular matrix associated with fibrosis
11) Confidence 0.27 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.52 Pain Relevance 0.20
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Negative_regulation (reduced) of MMP2 associated with metalloproteinase
12) Confidence 0.22 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.64 Pain Relevance 0.05
GLA infusion was associated with a decrease in MMP2 (35 ± 6.8%) mRNA expression (Figure 2A).
Negative_regulation (decrease) of MMP2
13) Confidence 0.22 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.51 Pain Relevance 0
The increase in net gelatinolytic activity found in the striatum of groups receiving supplementary oxygen for resuscitation stands in contrast to the decrease of MMP-9 and preservation of MMP-2 mRNA levels found in these experimental groups.
Negative_regulation (decrease) of MMP-2 in striatum
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.33 Pain Relevance 0.04
OBJECTIVE: To investigate the expressions of matrix metalloproteinase -2, -3 (MMP-2,-3) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in internal uterine endometriosis tissue and endometrium from women with and without endometriosis throughout the menstrual cycle.
Negative_regulation (inhibitor) of MMP-2 in internal associated with endometriosis and metalloproteinase
15) Confidence 0.12 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 16468658 Disease Relevance 0.27 Pain Relevance 0.35
Another study reported increased MMP-2 and MMP-9 activity and rapid degradation of occludin after temporary focal ischemia (38).
Negative_regulation (reported) of MMP-2 associated with ischemia and metalloproteinase
16) Confidence 0.11 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.90 Pain Relevance 0.19
Gene expressions of prolyl hydroxylase and tissue inhibitors of matrix metalloproteinase-2 were elevated.
Negative_regulation (inhibitors) of matrix metalloproteinase-2 associated with metalloproteinase
17) Confidence 0.10 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17616939 Disease Relevance 0.70 Pain Relevance 0.46
Furthermore, it has been shown that inhibition of MMP-2 and MMP-9 protects the blood-brain barrier during cerebral ischemia and that there is an increase in MMP-2 activity resulting from an increase in oxidative stress [16].
Negative_regulation (inhibition) of MMP-2 in brain associated with stress, cv general 4 under development and ischemia
18) Confidence 0.09 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 1.05 Pain Relevance 0.35
MCL gene expression of collagen type I, collagen type III, collagen type V, fibronectin, decorin, biglycan, lysyl oxidase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1, measured by real-time quantitative PCR, demonstrated differential expression in the HLU-healing groups compared with Amb-healing groups at both the 3- and 7-wk time points.
Negative_regulation (inhibitor) of matrix metalloproteinase-2 in MCL associated with metalloproteinase
19) Confidence 0.07 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17699562 Disease Relevance 0.21 Pain Relevance 0.22
In contrast, another study reported MMP-1 and MMP-2 to be highly expressed in eutopic but not ectopic endometrium of women with endometriosis and a decrease in the MMP-2 inhibitor (TIMP-2) [98], suggesting a role of MMP in the very early development of the disease.
Negative_regulation (decrease) of MMP-2 in endometrium associated with endometriosis, metalloproteinase and disease
20) Confidence 0.06 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.96 Pain Relevance 0.70

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