INT8747

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2011
Negated 8
Speculated 3
Reported most in Abstract
Documents 221
Total Number 229
Disease Relevance 154.28
Pain Relevance 35.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 29
fat 16
skeletal muscle 12
liver 12
blood 10
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 314 100.00 Very High Very High Very High
Inflammatory marker 26 100.00 Very High Very High Very High
antinociception 4 99.96 Very High Very High Very High
tolerance 1101 99.80 Very High Very High Very High
antagonist 403 99.80 Very High Very High Very High
tetrodotoxin 9 99.80 Very High Very High Very High
Paracetamol 70 99.74 Very High Very High Very High
fluoxetine 11 99.68 Very High Very High Very High
agonist 480 99.64 Very High Very High Very High
Inflammation 1293 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 4724 100.00 Very High Very High Very High
Insulin Resistance 2928 100.00 Very High Very High Very High
INFLAMMATION 1400 100.00 Very High Very High Very High
Body Weight 897 100.00 Very High Very High Very High
Hyperinsulinism 524 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 272 100.00 Very High Very High Very High
Apoptosis 245 100.00 Very High Very High Very High
Weight Gain 221 100.00 Very High Very High Very High
Diabetes Mellitus 2878 99.98 Very High Very High Very High
Birth Weight 4 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nortryptiline significantly increased glucose levels and reduced insulin levels in all animals.
Positive_regulation (increased) of insulin
1) Confidence 0.69 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10454053 Disease Relevance 0.48 Pain Relevance 0.43
Clonidine-induced hyperglycemia in lean littermates was not accompanied by a decrease in insulin levels, while a small but significant increase in insulin levels was observed by compound A administration.
Positive_regulation (increase) of insulin associated with hyperglycemia and clonidine
2) Confidence 0.67 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.94 Pain Relevance 0.84
Glycogen synthesis in diaphragm of ob/ob mice was enhanced after oral administration of compound A and was accompanied by an increase in plasma insulin levels.
Positive_regulation (increase) of insulin in plasma associated with obesity
3) Confidence 0.67 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.93 Pain Relevance 0.90
Moreover, both yohimbine and prazosin increased basal plasma insulin levels.
Positive_regulation (increased) of insulin in plasma
4) Confidence 0.67 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.30
Induction of a glucose-dependent insulin secretory response by the nonmetabolizable amino acid alpha-aminoisobutyric acid.
Positive_regulation (Induction) of insulin
5) Confidence 0.65 Published 1997 Journal Pancreas Section Title Doc Link 8981509 Disease Relevance 0.09 Pain Relevance 0.08
Plasma norepinephrine and epinephrine levels did not differ between Cap- and Veh-treated animals, whereas the increase in plasma insulin levels normally induced by alpha-adrenoceptor blockade by phentolamine was absent after Cap treatment.
Positive_regulation (increase) of insulin in plasma associated with qutenza
6) Confidence 0.64 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.23 Pain Relevance 0.98
Expression of Insulin, Glucokinase, and Cdk4 was up-regulated to the same extent in islets of adipocyte-deficient and ob/ob mice (Fig. 1 H), and insulin content was significantly increased in islets of adipocyte-deficient mice (Fig.
Positive_regulation (increased) of insulin in adipocyte associated with obesity
7) Confidence 0.56 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.65 Pain Relevance 0
A comparison of the time course for the increase in serum levels of ALT and insulin following a toxic dose of acetaminophen indicated that the increase in ALT preceded the increase in insulin.
Positive_regulation (increase) of insulin associated with paracetamol
8) Confidence 0.56 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2194324 Disease Relevance 0.43 Pain Relevance 0.79
A comparison of the time course for the increase in serum levels of ALT and insulin following a toxic dose of acetaminophen indicated that the increase in ALT preceded the increase in insulin.
Positive_regulation (increase) of insulin associated with paracetamol
9) Confidence 0.56 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2194324 Disease Relevance 0.44 Pain Relevance 0.79
Both the fasting plasma glucose (p = 0.01) and insulin (p = 0.02) were increased in HFC mice in comparison with SC mice.
Positive_regulation (increased) of insulin in plasma
10) Confidence 0.54 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.45 Pain Relevance 0
The mechanistic explanation for the induction of hepatic insulin resistance by dietary stearate remains to be determined.
Positive_regulation (induction) of insulin associated with insulin resistance
11) Confidence 0.51 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.47 Pain Relevance 0
Although neither fluoxetine nor sertraline induced changes in insulin levels, both significantly reduced the blood glucose levels of mice.
Neg (neither) Positive_regulation (induced) of insulin in blood associated with fluoxetine
12) Confidence 0.50 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10454053 Disease Relevance 0.49 Pain Relevance 0.43
A higher dose of U 50488h (10 mg/kg body wt i.p.) was required to produce significant increases in lean mouse plasma insulin (81 pM at 15 min) and glucose (0.7, 1.1, and 1.7 mM at 5, 15, and 30 min, respectively).
Positive_regulation (increases) of insulin in plasma
13) Confidence 0.50 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.32 Pain Relevance 0.34
Pretreatment with morphine (opioid agonist), 5-Hydroxytryptophan (5-HTP; 5-HT precursor), nicorandil (K(+) channel opener) and nimodipine (Ca(+) channel antagonist) significantly (p < 0.001) potentiated insulin antinociception, whereas naloxone (opioid antagonist), ketanserin (5-HT(2) receptor antagonist), pCPA (5-HT depleter), ondansetron (5-HT(3) receptor antagonist), L-dopa (dopamine precursor), reserpine (dopamine depleter), ketamine (NMDA receptor antagonist) and glibenclamide (K(+) channel blocker) significantly antagonized insulin antinociception (p < 0.001).
Positive_regulation (potentiated) of insulin associated with dopamine, narcan, morphine, antinociception, mu agonist, nmda receptor antagonist, ketamine, antagonist and opioid
14) Confidence 0.49 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 14988735 Disease Relevance 0.09 Pain Relevance 1.45
Doses of 100 and 200 mg/kg produced no evidence of hepatotoxicity and no increase in serum insulin; 300 mg/kg and higher doses produced both hepatotoxicity and increased serum insulin concentrations.
Positive_regulation (increased) of insulin associated with hepatotoxicity
15) Confidence 0.49 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2194324 Disease Relevance 0.43 Pain Relevance 0.78
Doses of 100 and 200 mg/kg produced no evidence of hepatotoxicity and no increase in serum insulin; 300 mg/kg and higher doses produced both hepatotoxicity and increased serum insulin concentrations.
Neg (no) Positive_regulation (increase) of insulin associated with hepatotoxicity
16) Confidence 0.49 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2194324 Disease Relevance 0.42 Pain Relevance 0.77
These observations suggest that the alpha 2-antagonist studied, increased plasma insulin levels with an accompanying reduction in blood glucose and an improvement in glucose tolerance in a genetic model of insulin resistance.
Positive_regulation (increased) of insulin in blood associated with antagonist, tolerance, insulin resistance and impaired glucose tolerance
17) Confidence 0.48 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.89 Pain Relevance 0.87
It is concluded that alpha 1- and alpha 2-adrenoceptor blockade is followed by enhancement of basal plasma insulin levels in the mouse, whereas alpha 2-adrenoceptor stimulation but not alpha 1-adrenoceptor stimulation impairs the insulin secretory response to glucose and carbachol.
Positive_regulation (enhancement) of insulin in plasma
18) Confidence 0.48 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.28
Plasma norepinephrine and epinephrine levels did not differ between Cap- and Veh-treated animals, whereas the increase in plasma insulin levels normally induced by alpha-adrenoceptor blockade by phentolamine was absent after Cap treatment.
Positive_regulation (increase) of insulin in plasma associated with qutenza
19) Confidence 0.46 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.23 Pain Relevance 0.98
In ob/ob mice, the agonist-induced rise in glucose did not cause the insulin response, because insulin levels were not elevated by a glucose challenge.
Neg (not) Positive_regulation (elevated) of insulin associated with obesity and agonist
20) Confidence 0.46 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.31 Pain Relevance 0.21

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