INT87491

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0.92
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CALCA, IL8) extracellular space (CALCA, IL8) extracellular region (CALCA, IL8)
aging (CALCA) cell-cell signaling (CALCA) cytoplasm (CALCA)
Anatomy Link Frequency
corneal epithelial cells 4
eye 2
sensory neurons 2
CALCA (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 60 100.00 Very High Very High Very High
Inflammation 10 99.18 Very High Very High Very High
antagonist 5 97.92 Very High Very High Very High
Neuropeptide 10 96.88 Very High Very High Very High
Pain 5 94.04 High High
chemokine 5 90.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.18 Very High Very High Very High
Pain 5 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The capacity of CGRP to stimulate cAMP and IL-8 synthesis was abrogated in the presence of the CGRP receptor antagonist CGRP8-37.
CGRP Positive_regulation (stimulate) of Gene_expression (synthesis) of IL-8 associated with antagonist and calcitonin gene-related peptide
1) Confidence 0.72 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.16 Pain Relevance 0.75
Because neutrophil infiltration of the clear corneal surface is a hallmark of corneal inflammation in the human eye, we determined whether CGRP can bind to human corneal epithelial cells (HCEC) and induce expression of the neutrophil chemotactic protein IL-8.
CGRP Positive_regulation (induce) of Gene_expression (expression) of chemotactic protein IL-8 in eye associated with inflammation and calcitonin gene-related peptide
2) Confidence 0.63 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.19 Pain Relevance 0.67
Calcitonin gene-related peptide induces IL-8 synthesis in human corneal epithelial cells.
gene-related peptide Positive_regulation (induces) of Gene_expression (synthesis) of IL-8 in corneal epithelial cells associated with calcitonin gene-related peptide
3) Confidence 0.63 Published 2000 Journal J. Immunol. Section Title Doc Link 10754330 Disease Relevance 0.18 Pain Relevance 0.71
Exposure of HCEC to CGRP induced a significant increase in intracellular cAMP levels and enhanced IL-8 <span style="backgrou</span>nd-color:#B0E0E6">synthesis nearly 4-fold.
CGRP Positive_regulation (enhanced) of Gene_expression (synthesis) of IL-8 in HCEC associated with calcitonin gene-related peptide
4) Confidence 0.52 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.18 Pain Relevance 0.76
The capacity of CGRP to stimulate IL-8 synthesis in HCEC suggests that sensory neurons are involved in induction of acute inflammation at the eye surface.
CGRP Positive_regulation (stimulate) of Gene_expression (synthesis) of IL-8 in sensory neurons associated with inflammation and calcitonin gene-related peptide
5) Confidence 0.48 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.21 Pain Relevance 0.64

General Comments

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