INT87495

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 13.85
Pain Relevance 9.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
fibroblasts 6
macrophage 5
peritoneal fluid 5
T cells 5
microglia 4
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 535 100.00 Very High Very High Very High
chemokine 333 100.00 Very High Very High Very High
metalloproteinase 76 100.00 Very High Very High Very High
Opioid 23 99.98 Very High Very High Very High
endometriosis 672 99.96 Very High Very High Very High
methotrexate 60 99.20 Very High Very High Very High
Calcitonin gene-related peptide 12 98.56 Very High Very High Very High
cytokine 233 97.64 Very High Very High Very High
Arthritis 238 97.20 Very High Very High Very High
Inflammatory response 24 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 562 100.00 Very High Very High Very High
Endometriosis 896 99.96 Very High Very High Very High
Acid Reflux 18 99.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 97.60 Very High Very High Very High
Juvenile Chronic Polyarthritis 160 97.20 Very High Very High Very High
Necrosis 33 97.20 Very High Very High Very High
Infection 29 96.92 Very High Very High Very High
Cancer 45 96.84 Very High Very High Very High
Sprains And Strains 15 96.80 Very High Very High Very High
Dyspepsia 24 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in RANTES gene expression in response to IL-1beta was confirmed by PCR and real-time PCR.
Positive_regulation (increase) of Gene_expression (expression) of RANTES
1) Confidence 0.69 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.08 Pain Relevance 0
Our results show that DAMGO administration induces a significant increase in RANTES and IP-10 expression, while MCP-1 protein levels remain unaffected in PBMCs infected with the HIV-1 strain.
Positive_regulation (increase) of Gene_expression (expression) of RANTES associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
2) Confidence 0.58 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11086093 Disease Relevance 1.03 Pain Relevance 0.90
The increase in RANTES gene expression in response to IL-1beta was confirmed by PCR and real-time PCR.
Positive_regulation (response) of Gene_expression (expression) of RANTES
3) Confidence 0.50 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.08 Pain Relevance 0
We demonstrate that the chemokines CCL5 (RANTES) and CCL3 (also known as macrophage inflammatory protein (MIP)-1?)
Positive_regulation (chemokines) of Gene_expression (demonstrate) of CCL5 in macrophage associated with chemokine and inflammation
4) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.10 Pain Relevance 0.72
We demonstrate that the chemokines CCL5 (RANTES) and CCL3 (also known as macrophage inflammatory protein (MIP)-1?)
Positive_regulation (chemokines) of Gene_expression (demonstrate) of RANTES in macrophage associated with chemokine and inflammation
5) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.10 Pain Relevance 0.72
Increased gene expression and protein production of RANTES in synovial fibroblasts, in response to IL-1beta, may play an important role in recruitment of inflammatory cells into synovium and progression of synovitis in TMD.


Positive_regulation (Increased) of Gene_expression (production) of RANTES in fibroblasts
6) Confidence 0.44 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.07 Pain Relevance 0
CD8+ T cells of the effector and memory compartments have been shown to express high levels of the CCR5 chemokine receptor [38] as well as producing the chemokine CCL5 [39,40].
Positive_regulation (levels) of Gene_expression (express) of CCL5 in T cells associated with chemokine
7) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.06 Pain Relevance 0.17
Production of CCL5 by synovial fluid T cells
Positive_regulation (Production) of Gene_expression (Production) of CCL5 in synovial fluid
8) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.34 Pain Relevance 0.33
Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells.
Positive_regulation (induction) of Gene_expression (expression) of RANTES in blood associated with opioid
9) Confidence 0.39 Published 2000 Journal J. Immunol. Section Title Doc Link 11086093 Disease Relevance 0.61 Pain Relevance 0.75
Our results show that DAMGO administration induces a significant increase in RANTES and IP-10 expression, while MCP-1 protein levels remain unaffected in PBMCs infected with the HIV-1 strain.
Positive_regulation (induces) of Gene_expression (expression) of RANTES associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
10) Confidence 0.39 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11086093 Disease Relevance 1.03 Pain Relevance 0.90
Also, increased expression of IFN-gamma was associated with a significant increase in expression of RANTES and monocyte chemotactic protein (MCP)-1, chemokines that may inhibit HIV-1 infection by blocking viral attachment to CCR2 and CCR5 co-receptors.
Positive_regulation (increase) of Gene_expression (expression) of RANTES in monocyte associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
11) Confidence 0.35 Published 2002 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12048358 Disease Relevance 0.85 Pain Relevance 0.76
Increases in gene expression of IL-8, GRO-alpha, MCP-1, and RANTES in response to TNF-alpha treatment were detected.
Positive_regulation (Increases) of Gene_expression (expression) of RANTES
12) Confidence 0.32 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.14 Pain Relevance 0
Increases in gene expression of IL-8, GRO-alpha, MCP-1, and RANTES in response to TNF-alpha treatment were detected.
Positive_regulation (response) of Gene_expression (expression) of RANTES
13) Confidence 0.32 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.14 Pain Relevance 0
The results suggest that HCEC possess CGRP receptors capable of initiating a signal transduction cascade that differentially activates expression of the IL-8 gene but not the genes for monocyte chemotactic protein-1 or RANTES.
Positive_regulation (activates) of Gene_expression (expression) of RANTES in HCEC associated with calcitonin gene-related peptide
14) Confidence 0.30 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.12 Pain Relevance 0.75
The use of a blocking mAb to TNF showed that TNF is not involved in the TWEAK-induced production of IL-8, MMP-1, PGE2, RANTES and IP-10 in dermal fibroblasts (Table 2) and in synoviocytes (Table 3).
Positive_regulation (induced) of Gene_expression (production) of RANTES in fibroblasts
15) Confidence 0.19 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0 Pain Relevance 0.03
The hamster anti-hTWEAK mAbs, BCB10 and BEB3, were tested for their effects on hTWEAK stimulation of IL-8, MMP-1, PGE2, IL-6, IP-10 and RANTES production by dermal fibroblasts.
Positive_regulation (stimulation) of Gene_expression (production) of RANTES in fibroblasts
16) Confidence 0.18 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0 Pain Relevance 0.07
Incubation with hTWEAK increased the production of prostaglandin E2, matrix metalloproteinase-1 (MMP-1), IL-6, and the chemokines IL-8, RANTES (regulated on activation, normal T expressed and secreted) and interferon-?
Positive_regulation (increased) of Gene_expression (production) of RANTES associated with chemokine and metalloproteinase
17) Confidence 0.18 Published 2002 Journal Arthritis Res Section Abstract Doc Link PMC83846 Disease Relevance 0.43 Pain Relevance 0.18
One step further, we found that EGCG significantly inhibited MMP-2 activity induced by RANTES/CCL5, Gro-?
Positive_regulation (by) of Gene_expression (/) of RANTES
18) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.50 Pain Relevance 0.59
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Positive_regulation (contributes) of Gene_expression (expression) of CCL5 in microglia associated with chemokine and inflammation
19) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.49 Pain Relevance 0.21
Using a 27 cytokine Bio-Plex assay to expand on our previous data, we found along with IL-6 and IL-8, significant B. burgdorferi-induced upregulation in expression of the pro-inflammatory chemokines CCL2, CCL3, CCL4 and CCL5 by microglial cells (Table 2).
Positive_regulation (upregulation) of Gene_expression (expression) of CCL5 in microglial cells associated with chemokine, inflammation and cytokine
20) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.28 Pain Relevance 0.29

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