INT87497

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cadps)
Anatomy Link Frequency
sciatic nerves 1
nerves 1
Cadps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 16 100.00 Very High Very High Very High
c fibre 18 99.98 Very High Very High Very High
Sciatic nerve 112 99.36 Very High Very High Very High
substance P 7 95.60 Very High Very High Very High
hyperexcitability 14 88.36 High High
Arthritis 6 80.68 Quite High
dorsal root ganglion 72 79.84 Quite High
Eae 36 72.24 Quite High
Pain 8 50.00 Quite Low
Neuropathic pain 26 37.52 Quite Low
Disease Link Frequency Relevance Heat
Nerve Compression Syndromes 62 99.20 Very High Very High Very High
Neuropathic Pain 34 88.96 High High
Injury 80 86.80 High High
Experimental Arthritis 5 80.68 Quite High
Ganglion Cysts 72 79.84 Quite High
Arthritis 2 75.00 Quite High
Non-diabetic Peripheral Neuropathy 6 49.76 Quite Low
INFLAMMATION 8 34.32 Quite Low
Nervous System Injury 18 5.00 Very Low Very Low Very Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paradigm resulted in four groups designated: CFA/CAPS, CFA/vehicle, vehicle/CAPS and vehicle/vehicle.
Positive_regulation (resulted) of CAPS associated with qutenza
1) Confidence 0.22 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10754399 Disease Relevance 0.30 Pain Relevance 1.24
At lower concentrations, the TTX-resistance of both the A-fiber and C-fiber CAPs was significantly increased in nerves ipsilateral to SNE (p < 0.05, two-way ANOVA with Tukey post-hoc) (Fig. 2A, B).


Positive_regulation (increased) of CAPs in nerves associated with c fibre and nerve compression syndromes
2) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.58 Pain Relevance 0.34
The CAP response amplitudes from contralateral, naïve control nerves, and ipsilateral sham nerves were similar and therefore grouped together. 2 weeks after SNE, the amplitudes of both A- and C-fiber CAPs were significantly increased in ipsilateral sciatic nerves when compared to control, sham or contralateral nerves (Fig. 1).
Positive_regulation (increased) of CAPs in sciatic nerves associated with c fibre, nerve compression syndromes and sciatic nerve
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.90 Pain Relevance 0.61

General Comments

This test has worked.

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