INT875

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2008
Negated 34
Speculated 19
Reported most in Abstract
Documents 166
Total Number 190
Disease Relevance 12.87
Pain Relevance 84.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 29
hypothalamus 17
brain 14
thyroid 10
arcuate nucleus 8
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 1156 100.00 Very High Very High Very High
Clonidine 422 100.00 Very High Very High Very High
antagonist 411 100.00 Very High Very High Very High
agonist 327 100.00 Very High Very High Very High
Morphine 208 100.00 Very High Very High Very High
Calcitonin gene-related peptide 158 100.00 Very High Very High Very High
Opioid 84 100.00 Very High Very High Very High
narcan 83 100.00 Very High Very High Very High
opiate 55 100.00 Very High Very High Very High
Intracerebroventricular 35 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Morphine Dependence 3 100.00 Very High Very High Very High
Disease 17 99.88 Very High Very High Very High
Hyperglycemia 8 99.82 Very High Very High Very High
Galactorrhea 20 99.76 Very High Very High Very High
Pressure Volume 2 Under Development 10 99.76 Very High Very High Very High
Stress 419 99.68 Very High Very High Very High
Obesity 48 99.32 Very High Very High Very High
Thyroid Disease 38 99.14 Very High Very High Very High
Diabetes Mellitus 16 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In female rats, chronic morphine reduced GH pulse amplitudes but did not significantly affect other parameters of GH secretion.
Neg (not) Regulation (affect) of Localization (secretion) of GH associated with morphine
1) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.69
Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats.
Regulation (Effects) of Localization (secretion) of GH associated with narcan and opiate
2) Confidence 0.62 Published 1993 Journal Life Sci. Section Title Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.73
These data suggest that endogenous opioid systems are involved in the regulation of the basal GH secretion in both male and female rats.
Regulation (regulation) of Localization (secretion) of GH associated with endogenous opioid
3) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.64
Clonidine microinjection into the amygdala nucleus had no effect on GH release, while the injection into the preoptic and anterior hypothalamic area (PO/AH) significantly stimulated GH release by causing it to begin 30 min earlier.
Neg (no) Regulation (effect) of Localization (release) of GH in anterior associated with amygdala and clonidine
4) Confidence 0.61 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.09 Pain Relevance 0.38
These results suggest that the serotonergic and endogenous opiate systems involved in regulation of GH secretion in rats are functional within the first postnatal week.
Regulation (regulation) of Localization (secretion) of GH associated with opiate
5) Confidence 0.61 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.50
The effects of adrenergic receptor agonists on GH secretion were studied in adult, male rats pretreated with reserpine and somatostatin antiserum.
Regulation (effects) of Localization (secretion) of GH associated with somatostatin and agonist
6) Confidence 0.61 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.19
The effects of thyroid hormone deprivation and of subsequent replacement therapy on growth hormone (GH) secretion were investigated in unrestrained unanesthetized rats.
Regulation (effects) of Localization (secretion) of GH in thyroid
7) Confidence 0.61 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.09 Pain Relevance 0.29
These results suggest that both mu- and kappa-opioid receptors are involved in the regulation of GH secretion in neonatal rats.
Regulation (regulation) of Localization (secretion) of GH associated with kappa opioid receptor
8) Confidence 0.61 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8793890 Disease Relevance 0 Pain Relevance 0.55
Histamine agonist and antagonist drugs: interference with CNS control of GH release in rats.
Regulation (control) of Localization (release) of GH associated with antagonist and agonist
9) Confidence 0.61 Published 1981 Journal Horm. Res. Section Title Doc Link 6116658 Disease Relevance 0 Pain Relevance 0.56
The beta-adrenergic agonist, isoprenaline, and antagonist, propranolol, had no effect on the delayed basal secretion of GH consistently observed in rats treated with the narco-analgesic gamma-hydroxybutyrate.
Neg (no) Regulation (effect) of Localization (secretion) of GH associated with analgesic, antagonist and agonist
10) Confidence 0.61 Published 1982 Journal J. Endocrinol. Section Abstract Doc Link 7119644 Disease Relevance 0 Pain Relevance 0.83
The effects of the administration into the brain ventricle of histamine, selective H1- and H2-receptor agonists and antagonists and chemically similar substances with nonspecific activity on basal and morphine-stimulated growth hormone (GH) secretion in normal male rats were studied.
Regulation (effects) of Localization (secretion) of GH in brain ventricle associated with antagonist, agonist and morphine
11) Confidence 0.61 Published 1981 Journal Horm. Res. Section Abstract Doc Link 6116658 Disease Relevance 0 Pain Relevance 0.55
To examine the mechanism of GH deficiency associated with the disease, the effect of pituitary stalk section on GH secretion was studied in rats.
Regulation (effect) of Localization (secretion) of GH in pituitary stalk associated with disease
12) Confidence 0.61 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1676866 Disease Relevance 0.18 Pain Relevance 0
The present studies examine catecholaminergic mechanisms which might regulate GH release in the neonatal rat.
Spec (might) Regulation (regulate) of Localization (release) of GH
13) Confidence 0.60 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.55
Findings suggest that noradrenergic mechanisms participate in the regulation of GH secretion in both neonatal and adult rats.
Regulation (participate) of Localization (secretion) of GH
14) Confidence 0.60 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.87
The data reported in this study are consistent with the interpretation that the neurotransmitter regulation of GH release and the modulation of hypothalamic glucoreceptor systems are not fundamentally different in rodents and primates.
Regulation (regulation) of Localization (release) of GH associated with neurotransmitter
15) Confidence 0.60 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.05 Pain Relevance 0.55
Under the same experimental conditions, dopamine agonists, apomorphine and levodopa, had no effect on GH secretion.
Neg (no) Regulation (effect) of Localization (secretion) of GH associated with dopamine and agonist
16) Confidence 0.60 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.16 Pain Relevance 0.59
These data demonstrate that in the infant rat: brain adrenergic mechanisms involved in the neural regulation of GH secretion are operative; different neuropeptide mechanisms mediate the effect of activation or inhibition of alpha 1- and alpha 2-adrenoceptors.
Regulation (regulation) of Localization (secretion) of GH in brain associated with neuropeptide
17) Confidence 0.60 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.52
The relationship between opioidergic and alpha 2-adrenergic system in the regulation of GH secretion was studied using a novel alpha 2-antagonist, CH-38083, and chronic treatment with yohimbine or clonidine.
Regulation (regulation) of Localization (secretion) of GH associated with antagonist and clonidine
18) Confidence 0.59 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 0.70
In rats chronically treated with clonidine (2 micrograms/ml in the drinking water for 14 days) the GH response to an injection of clonidine was blocked, while the effect of morphine on the GH secretion remained unchanged.
Regulation (effect) of Localization (secretion) of GH associated with morphine and clonidine
19) Confidence 0.59 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.53
L-Dopa administered intravenously and apomorphine administered intravenously or intraventricularly did not affect basal secretion of GH bu- produced a dose-dependnet inhibition of clonidine-induced GH release.
Neg (not) Regulation (affect) of Localization (secretion) of GH associated with clonidine
20) Confidence 0.59 Published 1978 Journal Horm. Res. Section Abstract Doc Link 669571 Disease Relevance 0 Pain Relevance 0.45

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